Cytokines and their regulators in rat lung following scorpion envenomation

Gunas, Valery; Maievskyi, Oleksandr; Synelnyk, Tatyana; Raksha, Nataliia; Vovk, Tetiana; Halenova, Tetiana; Savchuk, Olexiy; Gunas, Igor

doi:10.1016/j.toxcx.2024.100198

Toxicon: X

2024

DOI: 10.1016/j.toxcx.2024.100198

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Cytokines and their regulators in rat lung following scorpion envenomation

Valery Gunas,

Oleksandr Maievskyi,

Tatyana Synelnyk

et al.

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The influence of scorpion venom on the hypothalamo-pituitary-adrenal axis (review)

Kobzina-Didukh

2024

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Scorpion venom is an important subject of research because of its potential impact on the hypothalamic-pituitary-adrenal axis, which plays a key role in regulating the body's stress response. Studying this effect may contribute to the development of new therapeutic approaches for the treatment of stress and endocrine disorders. The purpose of this study is to review modern scientific sources devoted to the study of scorpion venom on the organs of the hypothalamic-pituitary-adrenal axis. For this, a search for literary sources related to the research topic in the period 2014-2024 was performed on the basis of Google Scholar, Scopus using keywords and inclusion/exclusion criteria, in particular, the presence of previous review of articles, the representativeness of the sample, and the presence of statistical analysis of the obtained data. An analysis of the literature on the effects of scorpion venom on the hypothalamic-pituitary-adrenal axis revealed several key aspects. First, the presence of specific biological mechanisms through which venom components affect the activity of this axis, including the secretion of corticosteroids, adrenocorticotropic hormone, or other stress hormones, has been confirmed. Secondly, the results of the analysis indicated the possible therapeutic prospects of using individual components of the venom to regulate the work of this system, which may be important in the treatment of various endocrine and stress disorders. Finally, the analysis helped identify gaps in existing research and outline directions for further experiments, which will contribute to a deeper understanding of the effects of scorpion venom on the hypothalamic-pituitary-adrenal axis.

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The influence of scorpion venom on the hypothalamo-pituitary-adrenal axis (review)

Kobzina-Didukh

2024

Rep. of Vinnytsia Nation. Med. Univ.

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Cytokines and their regulators in rat lung following scorpion envenomation

Cited by 1 publication

References 39 publications

The influence of scorpion venom on the hypothalamo-pituitary-adrenal axis (review)

The influence of scorpion venom on the hypothalamo-pituitary-adrenal axis (review)

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