Cytokines and Transgenic Matrix in Autoimmune Diseases: Similarities and Differences

Szewczak, Ludmiła; Donskow‐Łysoniewska, Katarzyna

doi:10.3390/biomedicines8120559

Cited by 2 publications

(2 citation statements)

References 126 publications

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“…The increased concentration of IFN- γ , IL-12, IL-17, TGF β -1 and TGF β -3 in serum is accompanied by the low expression of PD-1 on CD4+ and CD8+ T cells in the blood of RRMS patients. IL-12 enhances the ability of CD8+ T cells to modulate autoantigen-specific effector responses [ 12 ] and stimulates the production of IFN- γ and IL-17 by Th1 and Th17 cells [ 30 ]. TGF β -1 is one of the most important anti-inflammatory cytokines and plays an important role in the development of Th17 proinflammatory cells and Tregs.…”

Section: Discussionmentioning

confidence: 99%

Reduced Expression of PD-1 in Circulating CD4+ and CD8+ Tregs Is an Early Feature of RRMS

Machcińska

Kierasińska

Michniowska

et al. 2022

IJMS

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Altered regulatory T cell (Treg) function could contribute to MS. The expression of activating and inhibitory receptors influences the activity of Tregs. Our aim was to investigate T cell phenotypes in relapsing–remitting MS (RRMS) patients at an early phase of the disease. We examined the influence of demographic parameters on the distribution of CD4+ and CD8+ T cell subclasses by generalized linear modeling. We also studied the expression of the following markers—CTLA-4, GITR, PD-1, FoxP3, Helios, CD28, CD62L, CD103—on T cell subsets from peripheral blood with a 14-color flow cytometry panel. We used an antibody array to define the profiles of 34 Th1/Th2/Th17 cytokines in the serum. Expression of PD-1 and GITR on CD4+ and CD8+ Tregs was decreased in RRMS patients. The proinflammatory factors IFN-γ, IL-17, IL-17F, TGFβ-1, TGFβ-3, IL-1SRII, IL-12 p40, sgp130, IL-6sR were significantly increased in RRMS patients. Therefore, a deficiency of PD-1 and GITR immune checkpoints on CD4+ and CD8+ Tregs is a feature of RRMS and might underlie impaired T cell control.

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Section: Discussionmentioning

confidence: 99%

Reduced Expression of PD-1 in Circulating CD4+ and CD8+ Tregs Is an Early Feature of RRMS

Machcińska

Kierasińska

Michniowska

et al. 2022

IJMS

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“…In MS, upregulation of transforming growth factor β (TGF-β) and tumor necrosis factor α (TNF-α) signaling pathways is observed, while impaired activation of these pathways is evident in SLE, with an increase in the signal transducer and activator of transcription 4 (STAT4) axis. Common mechanisms include activation of STAT1, STAT3, interferon γ (IFN-γ) pathways and dysregulation of STAT5 phosphorylation [ 10 ]. Due to the small number of reports, it is difficult to outline the epidemiology of the co-occurrence of MS and SLE.…”

Section: Commentmentioning

confidence: 99%

Coexistence of multiple sclerosis and systemic lupus erythematosus – a case report

Dubaj,

Dembowska,

Bigosiński

et al. 2024

ppn

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Purpose: Multiple sclerosis (MS) and systemic lupus erythematosus (SLE) are two autoimmune diseases that are relatively common, especially in women. However, it is extremely rare for them to coexist in a single patient (only 18 cases have been recorded world wide). Both affect the nervous system and may manifest in identical ways. This creates significant difficulties, both in terms of dia gnosis and choice of appropriate therapy. Case description: A 54yearold female patient with quadriparesis, superficial sensory disturbance and gait and balance disorders was diagnosed with primary progressive MS according to McDonald's criteria. The magnetic resonance images were typical for MS. Pre viously, in 2013, she was diagnosed with SLE, treated successfully, and is currently in remission. After excluding neuropsychiatric lupus, ocrelizumab treatment was administered, with good clinical results. Comment: Adequate differentiation (magnetic resonance imaging, analysis of cerebrospinal fluid, clinical observation) as to whether the patient's symptoms are related to MS or to SLE nervous system involvement is the basis for proper diagnosis and treatment.

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Cytokines and Transgenic Matrix in Autoimmune Diseases: Similarities and Differences

Cited by 2 publications

References 126 publications

Reduced Expression of PD-1 in Circulating CD4+ and CD8+ Tregs Is an Early Feature of RRMS

Reduced Expression of PD-1 in Circulating CD4+ and CD8+ Tregs Is an Early Feature of RRMS

Coexistence of multiple sclerosis and systemic lupus erythematosus – a case report

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