Cytokines as a predictor of progression to valvular disease in children with rheumatic fever

Controlling acute rheumatic fever and rheumatic heart disease in developing countries

“…Lynskey et al [33] have now identified that natural truncation of protein RocA causes this hyperencapsulation and the associated characteristics of carriage longevity and transmissibility. Studies of cytokine responses and monocyte expression provide clues to the aberrant host responses occurring in ARF [34][35][36], including elevated levels of tumour necrosis factor (TNF) a and interleukin-8 [37]. Findings regarding interleukin-10 are inconsistent [35,36,38].…”