Cytokines as a predictor of COVID-19 severity: evidence from meta-analysis

Szarpak, Łukasz; Nowak, Błażej; Kosior, Dariusz A.; Zaczyński, Artur; Filipiak‬, Krzysztof J.; Jaguszewski, Miłosz

doi:10.20452/pamw.15685

Cited by 28 publications

(31 citation statements)

References 2 publications

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“…The baseline function of zinc is the reduction of the oxidative stress and inflammation [8]. Additionally, zinc is associated with the negative feedback loop decreasing the activity of nuclear factor kappa B, thus alleviating sepsis and excessive inflammation [9] and potentially reducing the cytokine storma phenomenon associated with severe COVID-19 [10]. Interestingly, the interaction between the angiotensin-converting enzyme-2 peptidase domain and SARS-CoV-2 spike protein, which is crucial for entry of the virus into the cell [11], is also modulated by the zinc levels [12].…”

Section: Introductionmentioning

confidence: 99%

Should we supplement zinc in COVID-19 patients? Evidence from meta-analysis

Szarpak¹,

Pruc²,

Jaguszewski³

et al. 2021

Polish Archives of Internal Medicine

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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited, distributed under the same license, and used for noncommercial purposes only.

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Section: Introductionmentioning

confidence: 99%

Should we supplement zinc in COVID-19 patients? Evidence from meta-analysis

Szarpak¹,

Pruc²,

Jaguszewski³

et al. 2021

Polish Archives of Internal Medicine

Self Cite

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“…The mechanisms potentially explaining the association between COVID-19 and CVD include cytokine storm and thrombotic microangiopathy [95,96]. Severe COVID-19 is associated with a cytokine storm, reflected by elevated concentrations of TNF-α, IL-1β, IL-2, IL-6, CRP, and ferritin [97].…”

Section: Severe Acute Respiratory Syndrome Coronavirus-2 (Sars-cov-2)mentioning

confidence: 99%

Infections as Novel Risk Factors of Atherosclerotic Cardiovascular Diseases: Pathophysiological Links and Therapeutic Implications

Szwed

Zawadka

Eyileten

et al. 2021

JCM

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Atherosclerotic cardiovascular diseases (ASCVD) are the major cause of mortality worldwide. Despite the continuous progress in ASCVD therapy, the residual risk persists beyond the management of traditional risk factors. Several infections including Helicobacter pylori infection, periodontal disease, and viral infections are associated with the increased risk of ASCVD, both directly by damage to the heart muscle and vasculature, and indirectly by triggering a systemic proinflammatory state. Hence, beyond the optimal management of the traditional ASCVD risk factors, infections should be considered as an important non-classical risk factor to enable early diagnosis and appropriate treatment. Here, we summarized the currently available evidence regarding the role of inflammation in ASCVD and the association between the particular infections and pathogens (Helicobacter pylori, periodontal disease, pneumonia, Cytomegalovirus, Human immunodeficiency virus, Herpes simplex virus, and severe acute respiratory syndrome coronavirus 2) on the development and progression of ASCVD. We also speculated about the potential therapeutic implications of the anti-inflammatory and anti-infective drugs on ASCVD outcomes, including drugs routinely administered in patients with ASCVD (statins, P2Y12 receptor inhibitors, and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) and novel strategies aiming at residual risk reduction (colchicine, anti-cytokine drugs, and methotrexate). Considering the emerging association between infections and ASCVD, it is crucial to determine the possible advantages of infection prevention and treatment in patients with ASCVD.

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“…: structural and electrical atrial remodeling through fibrosis, hypertrophy, inflammation or oxidative stress [ 9 , 11 , 12 ]. Acute inflammation in the course of COVID-19 may alter atrial electrophysiology and structural substrates, therefore playing a major role in the development of these conditions in patients with COVID-19 [ 13 ]. Due to the well-established links between inflammation and AF, the association between COVID-19 and AF constitutes an interesting and thus far, unexplored subject.…”

Section: Introductionmentioning

confidence: 99%