Cytokines as adjuvants for avian vaccines

Asif, Manija; Jenkins, Kristie A.; Hilton, Louise; Kimpton, Wayne G.; Bean, Andrew G. D.; Lowenthal, John W.

doi:10.1111/j.1440-1711.2004.01295.x

Cited by 71 publications

(28 citation statements)

References 54 publications

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“…Cytokines are naturally derived proteins that play a crucial role in controlling the immune system, and are produced in response to infection (Asif et al, 2004). In avian coccidiosis, the cytokine IFN-γ has been found to be important in immunoregulation (Chapman, 2014;Dalloul and Lillehoj, 2006).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of chimeric DNA vaccines encoding Eimeria tenella 5401 and chicken IFN-γ or IL-2 against coccidiosis in chickens

Song

Huang

Ren

et al. 2015

Experimental Parasitology

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Section: Discussionmentioning

confidence: 99%

Efficacy of chimeric DNA vaccines encoding Eimeria tenella 5401 and chicken IFN-γ or IL-2 against coccidiosis in chickens

Song

Huang

Ren

et al. 2015

Experimental Parasitology

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“…If a non-replicative vector for C. perfringens antigens were to be injected in ovo, it is possible that protective antibodies would already be in decline at the time the disease occurs. Furthermore, the choice of the adjuvant is important as some adjuvants are known for inducing embryotoxic side effects (Asif et al, 2004). According to our knowledge there are no studies reporting efficacy of in ovo vaccination against necrotic enteritis.…”

Section: The Future Of Vaccine Delivery and Immunization Methods For mentioning

confidence: 99%

Progress and problems in vaccination against necrotic enteritis in broiler chickens

et al. 2014

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Necrotic enteritis in broilers is caused by Clostridium perfringens type A strains that produce the NetB toxin. Necrotic enteritis is one of the gastrointestinal diseases in poultry that has gained worldwide importance during the last decade due to efforts to improve broiler performance. Prevention strategies include avoiding predisposing factors, such as coccidiosis, and in-feed supplementation with a variety of feed additives. However, vaccination with modified toxin or other secreted immunogenic proteins seems a logical preventive tool for protection against a toxin-producing bacterium. Formalin-inactivated crude supernatant has been used initially for vaccination. Several studies have been carried out recently to identify the most important immunogenic and protective proteins that can be used for vaccination. These include the NetB toxin, as well as a number of other proteins. There is evidence that immunization with single proteins is not protective against severe challenge and that combinations of different antigens are needed. Most published studies have used multiple dosage vaccination regimens that are not relevant for practical use in the broiler industry. Single vaccination regimens for 1-day-old chicks appear to be non-protective. This review describes the history of vaccination strategies against necrotic enteritis in broilers and gives an update on future vaccination strategies that are applicable in the field. These may include breeder hen vaccination, in ovo vaccination and live attenuated vectors to be used in feed or in drinking water

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“…In addition, there is increasing consumer and governmental pressure to reduce or remove drugs from feed manufactured for food animals (Young and Craig, 2001). These factors have promoted the exploration of a variety of antimicrobial feed additives and immunotherapies such as vaccination and cytokine therapies for use as alternative control strategies (Barrow et al, 2003;Asif et al, 2004;Lowry et al, 2005;Doyle and Erickson, 2006). Specifically, vaccines (live, attenuated, and killed) developed against Salmonella spp.…”

Section: Introductionmentioning

confidence: 99%

Intestinal Cytokine Response of Commercial Source Broiler Chicks to Salmonella Typhimurium Infection

et al. 2008

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Development of molecular-based immunotherapeutic strategies for controlling Salmonella Typhimurium (ST) infection in poultry requires a better understanding of intestinal and cecal cytokine responses. Accordingly, an experiment was conducted to measure changes in intestinal cytokine expression when commercial source broiler chickens were challenged with a nalidixic acid-resistant ST. Ross broiler chicks were nonchallenged with ST (control treatment) or challenged by orally giving 7.8 x 10(6) cfu at 4 d of age (STC treatment). Each treatment consisted of 4 replicate pens with 14 chicks per pen. Expression levels of proinflammatory cytokines, interferon-gamma, and antiinflammatory interleukin (IL)-10 were determined at 5 and 10 d postchallenge (PC). Intestinal flushes were also collected from each treatment at 7 d PC to estimate IgA and IgG. Results showed an upregulation in IL-1beta mRNA in STC chicks at 5 d PC. By 10 d PC, the expression of IL-1beta was further increased and accompanied by an upregulation of IL-6 and interferon-gamma mRNA, whereas IL-10 mRNA expression decreased. It was concluded that ST induced an intestinal mucosal inflammatory response in commercial source broiler chicks less than 2 wk of age.

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Cytokines as adjuvants for avian vaccines

Cited by 71 publications

References 54 publications

Efficacy of chimeric DNA vaccines encoding Eimeria tenella 5401 and chicken IFN-γ or IL-2 against coccidiosis in chickens

Efficacy of chimeric DNA vaccines encoding Eimeria tenella 5401 and chicken IFN-γ or IL-2 against coccidiosis in chickens

Progress and problems in vaccination against necrotic enteritis in broiler chickens

Intestinal Cytokine Response of Commercial Source Broiler Chicks to Salmonella Typhimurium Infection

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