Cytokines as Mediators of Pain‐Related Process in Breast Cancer

Panis, Carolina; Pavanelli, Wander Rogério

doi:10.1155/2015/129034

Cited by 32 publications

(28 citation statements)

References 49 publications

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“…Recently we have demonstrated that the positive and negative estrogen tumors show different metabolic patterns ( manuscript in press ). Finally, tumors that do not exhibit any of these receptors are classified as triple negative [21]. Breast cancer develops within a specialized tumor microenvironment that consists of numerous cell types including cancer cells, stromal cells, adipose, and infiltrating immune cells.…”

Section: “Cytokinome” and Breast Cancermentioning

confidence: 99%

Serum Cytokinome Profile Evaluation: A Tool to Define New Diagnostic and Prognostic Markers of Cancer Using Multiplexed Bead-Based Immunoassays

Capone

Guerriero

Sorice

et al. 2016

Mediators of Inflammation

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In recent years, many researchers are focusing their attention on the link between inflammation and cancer. The inflammation is involved in the tumor development and suppression, by stimulating the immune response. In particular, the transition from chronic inflammation to cancer produces angiogenic and growth factors able to repair the tissue and to promote cancer cell survival, implantation, and growth. In this contest, the cytokines contribute to the development of these processes becoming active before and during the inflammatory process and playing an important function at the various disease levels. Thus, these proteins can represent specific markers of tumor development and progression. Therefore the “cytokinome” term is used to indicate the evaluation of cytokine pattern by using an “omics” approach. Newly, specific protein chips of considerable and improved sensitivity are being developed to determine simultaneously several and different cytokines. This can be achieved by a multiplex technology that, through the use of small amounts of serum or other fluids, is used to determine the presence and the levels of underrepresented cytokines. Since this method is an accurate, sensitive, and reproducible cytokine assay, it is already used in many different studies. Thus, this review focuses on the more latest aspects related to cytokinome profile evaluation in different cancers.

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Section: “Cytokinome” and Breast Cancermentioning

confidence: 99%

Serum Cytokinome Profile Evaluation: A Tool to Define New Diagnostic and Prognostic Markers of Cancer Using Multiplexed Bead-Based Immunoassays

Capone

Guerriero

Sorice

et al. 2016

Mediators of Inflammation

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“…Modulation of epigenetic markers represents the novelty of cancer-related research, and PTX may also regulate the expression of certain microRNAs (miRNAs) associated with cancer progression. Furthermore, PTX can exert a variety of positive influences on the modulation of immune response via regulation of chemokines, cytokines, or immune cells [11,12]. The resistance of BC to PTX and other chemotherapeutics as a consequence of disequilibrium in various signaling pathways, mutations in certain genes, and epigenetic deregulations is responsible for the worse clinical outcome for patients with BC [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer

et al. 2019

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Paclitaxel (PTX), the most widely used anticancer drug, is applied for the treatment of various types of malignant diseases. Mechanisms of PTX action represent several ways in which PTX affects cellular processes resulting in programmed cell death. PTX is frequently used as the first-line treatment drug in breast cancer (BC). Unfortunately, the resistance of BC to PTX treatment is a great obstacle in clinical applications and one of the major causes of death associated with treatment failure. Factors contributing to PTX resistance, such as ABC transporters, microRNAs (miRNAs), or mutations in certain genes, along with side effects of PTX including peripheral neuropathy or hypersensitivity associated with the vehicle used to overcome its poor solubility, are responsible for intensive research concerning the use of PTX in preclinical and clinical studies. Novelties such as albumin-bound PTX (nab-PTX) demonstrate a progressive approach leading to higher efficiency and decreased risk of side effects after drug administration. Moreover, PTX nanoparticles for targeted treatment of BC promise a stable and efficient therapeutic intervention. Here, we summarize current research focused on PTX, its evaluations in preclinical research and application clinical practice as well as the perspective of the drug for future implication in BC therapy.

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“…Additionally, significant increases in the plasma levels of proinflammatory cytokines (TNF-α, IL-1b, IL-6 and IL-8) are found in patients with intestinal disorders favoring mucosal inflammation, including constipation-predominant IBS [51,52]. This correlation can be explained by the sustained stimulation of nociceptors in chronic pain by proinflammatory cytokines pathway, resulting in local hypersensitivity, hypersensitivity in the adjacent regions and increased Central Nervous System responsiveness through chemical, physical or mechanical stimuli [53,54].…”

Section: Discussionmentioning

confidence: 99%

Constipation in patients with myofascial pain syndrome as important aspect for clinical and nutritional treatment: A case-control study

et al. 2017

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A B S T R A C T ObjectiveTo identify the occurrence of constipation in patients with myofascial pain syndrome and to correlate these disorders with the clinical and nutritional variables. MethodsThis report describes a case-control study performed with 98 adults of both sexs, including 49 patients and 49 individuals without pain. The intensity of the reported pain was evaluated using the Pain Visual Analog Scale, which provided a simple and efficient measurement of pain intensity consisting of a 10cm horizontal line with Revista de NutriçãoRev. Nutri., Campinas, 30(5):567-581, set./out., 2017 https://doi.org/10.1590/1678-98652017000500003 568 JA BARROS-NETO et al.the ends marked "absence of pain" and "worst possible pain". The occurrence of constipation was evaluated using the Rome III criteria. A multivariate linear regression was proposed to investigate risk factors between the frequency of bowel movements per week and independent variables this study. ResultsThe mean ages of the patients and controls were 45.9 (7.6) years and 41.2 (12.2) years, respectively. The intensity of the reported pain showed a mean of 7.3 (1.6) points. The likelihood of exhibiting constipation was 4.5 times higher in the patients than in the controls (p=0.001). The number of stools per week was negatively correlated with the intensity of the reported pain (r=-0.613, p<0.001). The use of benzodiazepines was negatively correlated with the frequency of bowel movements per week, while the use of muscle relaxants appeared to increase the frequency of defecation when combined with the use of benzodiazepines and adjusted for the intake of fiber, water and sexs (p=0.037). ConclusionConstipation was a frequent nosological entity in this patient population and the persistence of a change in intestinal motility showed a significant correlation with the pain intensity and low water intake. The reduction of the number of stools per week seems to be associated with the use of benzodiazepines.Keywords: Chronic pain. Constipation. Myofascial pain syndromes. (r=-0,613, p<0,001 R E S U M O Objetivo Identificar a ocorrência de constipação em pacientes com síndrome dolorosa miofascial e correlacionar essa desordem da motilidade intestinal com variáveis clínicas e nutricionais. Métodos Trata-se de um estudo de caso-controle, realizado com 98 indivíduos adultos de ambos os sexos I N T R O D U C T I O NChronic pain is considered a serious and growing public health problem worldwide. Affected people require medical attention approximately five times more frequently than the rest of the population. These patients have impaired physical, mental and social wellbeing, resulting in disability and work absenteeism [1,2].Myofascial Pain Syndrome (MPS) is characterized by regional chronic muscle pain located in a single muscle or in muscle groups.Revista de Nutrição Rev. Nutri., Campinas, 30(5):567-581, set./out., 2017 CONSTIPATION IN PATIENTS WITH MYOFASCIAL PAIN SYNDROME 569

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Cytokines as Mediators of Pain‐Related Process in Breast Cancer

Cited by 32 publications

References 49 publications

Serum Cytokinome Profile Evaluation: A Tool to Define New Diagnostic and Prognostic Markers of Cancer Using Multiplexed Bead-Based Immunoassays

Serum Cytokinome Profile Evaluation: A Tool to Define New Diagnostic and Prognostic Markers of Cancer Using Multiplexed Bead-Based Immunoassays

Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer

Constipation in patients with myofascial pain syndrome as important aspect for clinical and nutritional treatment: A case-control study

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