Cytokines/chemokines and soluble immune checkpoint molecules in anti-GABAB receptor encephalitis

Qiao, Shan; Xie, Yunfang; Li, Haiyun; Zhang, Ranran; Wu, Yumin; Liu, Xuewu; Zhang, Shanchao

doi:10.1016/j.msard.2022.104234

Cited by 3 publications

(3 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fasting blood samples of seven patients with NMDAR-E were collected on the day following their arrival, while they were still experiencing active disease symptoms, prior to the initiation of immunotherapy, as described in our previous reports. 10,11 These samples were promptly frozen at a temperature of −80°C until they could be analyzed.…”

Section: Sample Collectionmentioning

confidence: 99%

“…The testing was carried out following the manufacturer's instructions, as described in previous studies. 10,11…”

Section: Human Inflammation Molecular Arraymentioning

confidence: 99%

“…Distinct serum cytokines and the association of them with inflammatory CSF signatures in NMDAR-E, LGI1-E and GABABR-E On the basis of the results of our previous studies, 10,11 we investigated whether serum cytokines could serve as inflammatory biomarkers, separating the three AE categories and inferring their underlying pathology, as well as determining their association with CSF inflammatory parameters. To differentiate between NMDAR-E, LGI1-E, and GABABR-E cases, a representative PCA score plot was constructed using cytokine data (Figure S7A).…”

Section: Effect Of Disease Duration On Inflammatory Csf Changes In Nm...mentioning

confidence: 99%

See 2 more Smart Citations

CSF Findings in Chinese Patients with NMDAR, LGI1 and GABABR Antibody-Associated Encephalitis

Qiao,

Li,

Cui

et al. 2024

JIR

Self Cite

View full text Add to dashboard Cite

CSF inflammation in subtypes of antibody-defined autoimmune encephalitis (AE) ranges in intensity from moderate to severe. In a retrospective, cross-sectional study, we characterized CSF findings in Chinese patients with anti-N-methyl-D-aspartate receptor encephalitis (NMDAR-E), anti-leucine-rich glioma-inactivated 1 encephalitis (LGI1-E), and anti-gamma aminobutyric acid-B receptor encephalitis (GABABR-E). Patients and Methods: The AE cases, including 102 NMDAR-E, 68LGI1-E and 15 GABABR-E, were included. CSF inflammatory parameters consisted primarily of CSF leukocytes, oligoclonal bands (OCBs), and CSF/serum albumin ratios (Q Alb ). Ten serum cytokines were evaluated in order to classify AE subtypes. Results: 88% of NMDAR-E, 80% of GABABR-E, and 51% of LGI1-E patients had aberrant CSF features. In NMDAR-E, the CSF leukocyte count, CSF protein concentration, and age-adjusted Q Alb were significantly higher than in LGI1-E, but did not differ from GABABR-E. Blood-CSF barrier dysfunction was less common in NMDAR-E patients with >40 years old. On admission, inflammatory CSF response was more prevalent in NMDAR-E patients with a higher CASE score. With age <60 years, CSF inflammatory changes were less frequent in LGI1-E patients, but more common in GABABR-E patients. MCP-1, IL-10, IL-1β, and IL-4 were potential classifiers for NMDAR-E, LGI1-E, and GABABR-E, and correlated substantially with CSF leukocyte count and Q Alb . Conclusion: Subtype-specific patterns are formed by the various inflammatory CSF parameters in NMDAR-E, LGI1-E, and GABABR-E, and their correlation with disease severity, age, and disease duration. CSF inflammatory characteristics associated with MCP-1, IL-10, IL-1β, and IL-4 may be potential immunopathogeneses targeting markers for these AE subtypes.

show abstract

Section: Sample Collectionmentioning

confidence: 99%

“…The testing was carried out following the manufacturer's instructions, as described in previous studies. 10,11…”

Section: Human Inflammation Molecular Arraymentioning

confidence: 99%

Section: Effect Of Disease Duration On Inflammatory Csf Changes In Nm...mentioning

confidence: 99%

See 1 more Smart Citation

CSF Findings in Chinese Patients with NMDAR, LGI1 and GABABR Antibody-Associated Encephalitis

Qiao,

Li,

Cui

et al. 2024

JIR

Self Cite

View full text Add to dashboard Cite

show abstract

Diagnostic signatures and immune cell infiltration characteristics in anti-GABABR encephalitis

Qiao,

Zhang,

Xie

et al. 2024

Journal of Neuroimmunology

View full text Add to dashboard Cite

Clinical characteristics, immunological alteration and distinction of MOG-IgG-associated disorders and GFAP-IgG-associated disorders

Zeng,

He,

Kuang

et al. 2024

Journal of Neuroimmunology

View full text Add to dashboard Cite

Cytokines/chemokines and soluble immune checkpoint molecules in anti-GABAB receptor encephalitis

Cited by 3 publications

References 51 publications

CSF Findings in Chinese Patients with NMDAR, LGI1 and GABABR Antibody-Associated Encephalitis

CSF Findings in Chinese Patients with NMDAR, LGI1 and GABABR Antibody-Associated Encephalitis

Diagnostic signatures and immune cell infiltration characteristics in anti-GABABR encephalitis

Clinical characteristics, immunological alteration and distinction of MOG-IgG-associated disorders and GFAP-IgG-associated disorders

Contact Info

Product

Resources

About