Cytokines in Innate Immunity

Dembić, Zlatko

doi:10.1016/b978-0-12-818731-9.00090-2

Encyclopedia of Infection and Immunity 2022

DOI: 10.1016/b978-0-12-818731-9.00090-2

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Cytokines in Innate Immunity

Zlatko Dembić

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2024

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Cited by 1 publication

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Towards understanding the role of nanomedicine in targeting TNFR2 in rheumatoid arthritis

Lambuk,

Nordin,

Mussa

et al. 2024

Immunology

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Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovium and progressive joint destruction which significantly affects both quality of life and socioeconomic status. Admittedly, various treatments are available, but they are usually accompanied by various side effects, from mild to severe, and potentially with adverse events. Tumour necrosis factor‐alpha (TNF‐α) plays a crucial role in the pathophysiology of RA. It promotes inflammatory, apoptosis and necroptosis via TNF receptor‐1 (TNFR1) but elicit anti‐inflammatory effects via TNFR2. Herein, targeting TNFR2 has gained attention in RA studies. Understanding the role of nanomedicine in modulating TNFR2 signalling may be the instrument in development of RA therapies. Nanotechnology has made a significant progress in treating various conditions of diseases since its inception. Due to this, nanomedicine has emerged as a promising therapeutics approach for RA. Recent studies have demonstrated the potential of nanomedicine in RA theranostics, combining therapy and diagnostics for improved treatment outcomes. Owing to the challenges and advancements in the field of nanotechnology, nanoparticles are seen as an applicable candidate in the treatment of RA. In this review, we provide an overview of the role of nanomedicine in targeting TNFR2 for the treatment of RA and highlight the limitations of current therapies as well as the potential of nanocarriers with controlled drug release and active targeting abilities.

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Towards understanding the role of nanomedicine in targeting TNFR2 in rheumatoid arthritis

Lambuk,

Nordin,

Mussa

et al. 2024

Immunology

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show abstract

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Cytokines in Innate Immunity

Cited by 1 publication

References 194 publications

Towards understanding the role of nanomedicine in targeting TNFR2 in rheumatoid arthritis

Towards understanding the role of nanomedicine in targeting TNFR2 in rheumatoid arthritis

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