Cytokines in large intestine mucosa and intestinal microbiota in patients with chronic pancreatitis

Быкова, А. П.; Козлова, И. В.

doi:10.14300/mnnc.2017.12044

Cited by 3 publications

(1 citation statement)

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“…Полученные нами результаты подтверждают сложный механизм развития саркопении и остеопении при ХП, а также тесную взаимосвязь этих состояний. Наряду с общепризнанными факторами риска нарушения состава тела -ВСНПЖ, мальабсорбция -определенную роль играют изменения кишечника на фоне системного воспаления при ХП [30]. Вклад в развитие реакции системного воспаления может вносить повышение проницаемости кишечной стенки с гиперпродукцией тканевых цитокинов наряду с кишечным дисбиозом [31].…”

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Osteosarcopenia in chronic pancreatitis

Козлова

Вадимовна²,

Быкова

et al. 2021

Terapevticheskii arkhiv

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Aim. To determine clinical features and some mechanisms of osteosarcopenia development in patients with chronic pancreatitis (CP). Materials and methods. A casecontrol study was conducted on the basis of the Saratov State Clinical Hospital 5 in 20152018 of patients with CP. In a study of 161 patients with CP included, the control group 30 healthy individuals. Patients were divided into groups according to the etiology of CP: 79 with toxic-metabolic CP, 82 with biliary CP. To determine the risks of low-energy fractures, 154 patients were tested with the Fracture risk assessment tool (FRAX). Along with the standard examination, 30 patients with CP dual-energy X-ray absorptiometry was performed. To assess the state of skeletal muscles, body mass index was determined, hand-held dynamometry was performed, and a set of Short Physical Performance Battery (SPPB) tests was used. Along with the assessment of traditional risk factors for osteosarcopenia gender, age, state of reproductive function in women, body mass index, functional state of the pancreas (pancreas) the quantitative content of interleukins (IL)-2, 6, 8 in in colonic biopsies was analyzed by enzyme-linked immunosorbent assay (ELISA). Results. Bone disorders, according to densitometry, was detected in 70.0% of patients with CP, in 13.3% of the control group. Presarcopenia was detected in 62 (38.5%) patients with CP, sarcopenia in 34 (21.1%), in the control group presarcopenia and sarcopenia were not detected. Sarcopenia was statistically significantly more common in toxic-metabolic CP than in biliary CP (2=11.6; p0.001). Correlations of the lumbar spine T-score and IL-6 (r=-0.29; p=0.03), IL-8 (r=-0.29; p=0.04) were revealed. Correlations between sarcopenia and the concentration of cytokines in the in the colon mucosa in CP were determined (IL-2: r=0.44; p0.001; IL-6: r=0.48; p0.001; IL-8: r=0.42; p0.001). Conclusion. The development of osteopenia and sarcopenia syndromes in CP is interrelated and associated with both traditional risk factors and an increased concentration of cytokines in the in the colon mucosa.

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Section: Discussionunclassified

Osteosarcopenia in chronic pancreatitis

Козлова

Вадимовна²,

Быкова

et al. 2021

Terapevticheskii arkhiv

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Analysis of Functional and Clinical Symptoms in Patients With Classical and Mediated Hypersecretory Diseases of the Gastrointestinal Tract

Mohamed

Usmanova

Ishmukhametova

et al. 2022

Actual Problems in Dentistry

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Relevance. The authors found that the development of mucosal pathology is influenced by classical (major) and mediated hypersecretory diseases of the gastrointestinal tract. Kyoto Consensus (2014) suggested that gastroenterological patients have manifestations of functional dyspepsia, the mucosa of the stomach and duodenum has increased sensitivity to excessive production of hydrochloric acid, and various pathological changes are observed on the mucosa of the oral cavity proper. The aim was study of the relationship between the severity of dyspeptic disorders on the 7×7 questionnaire and clinical features of oral mucosal pathology manifestations in patients with classical and mediated hypersecretory diseases of the gastrointestinal tract. Materials and Methods. The study included 105 patients with the presence of classical gastrointestinal disease (simple non-atrophic chronic gastritis with dyspepsia syndrome after eradication of H.pylori) and hypersecretory mediated gastrointestinal disease (chronic pancreatitis) with increased or normal production of hydrochloric acid in the stomach. Clinical condition of oral mucosa corresponded to the presence of manifestations of classical and mediated hypersecretory diseases of the gastrointestinal tract. To assess pain intensity we used pain index index (PIH) according to Hossley-Bergman scale, examination of symptoms of functional dyspepsia (FD) and irritable bowel syndrome (IBS) was carried out by means of questionnaire "7×7". To determine statistical differences we used chi-square test, including Yates-adjusted test and Mann-Whitney test. Results. In the clinical group with classic hypersecretory gastrointestinal disease only in 25,71% of cases pathology of oral mucosa was revealed. On the background of clinical manifestations in mediated GIT pathology of oral mucosa – oral candidiasis, cheilitis, glossitis, burning sensation of the oral cavity was revealed in 100% of cases. Dyspeptic disorders according to 7×7 questionnaire prevailed in persons with indirect hypersecretory gastrointestinal disease in the form of chronic pancreatitis with GERD symptoms.

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Is it necessary to correct the intestinal microbiota disorders in chronic pancreatitis?

Ardatskaya

Maslovsky

Зверков

2022

jour

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The frequency of intestinal microbiota disorders in patients with chronic pancreatitis (CP) is extremely high and can reach 97%. The bacterial overgrowth syndrome (SIBO) and the syndrome of increased epithelial permeability (SPEP), developing against the background of excretory insufficiency of the pancreas, affect the severity of the clinical picture of the disease, reduce the effectiveness of enzyme replacement therapy and generally contribute to the further progression of CP.The article presents a modern view on the mechanisms of the formation of SIBO and SPEP in CP. There is their aggravating effect on the course of the disease and the aggravation of disorders of the digestive and absorption processes that accompany them is shown and analyzed in the article.For decontamination of conditionally pathogenic and pathogenic ﬂora, increasing the number and metabolic activity of indigenous microﬂora in patients with CP, the use of a non-absorbable broad-spectrum antibiotic rifaximin is eﬀective. In order to restore the barrier function of the gastrointestinal mucosa, the drug of choice is rebamipid, a universal cytoprotector that affects all three levels of epithelial tissue protection (preepithelial, epithelial and subepithelial).Conclusion. CP is characterized by the complexity of its etiology and pathogenesis. Bacterial factors, in particular, SIBO and SPEP, play an essential role in the development of inﬂammatory changes in the pancreas. In the complex therapy of CP, it is advisable to take measures aimed at correcting disorders of the intestinal microbiota.

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Cytokines in large intestine mucosa and intestinal microbiota in patients with chronic pancreatitis

Cited by 3 publications

References 0 publications

Osteosarcopenia in chronic pancreatitis

Osteosarcopenia in chronic pancreatitis

Analysis of Functional and Clinical Symptoms in Patients With Classical and Mediated Hypersecretory Diseases of the Gastrointestinal Tract

Is it necessary to correct the intestinal microbiota disorders in chronic pancreatitis?

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