Cytokines in mammalian reproduction and speculation about their possible involvement in nonmammalian viviparity

Paulesu, Luana

doi:10.1002/(sici)1097-0029(19970701/15)38:1/2<188::aid-jemt19>3.0.co;2-l

Cited by 30 publications

(10 citation statements)

References 55 publications

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“…Many cytokines and their specific receptors have been found in the mammalian placenta independently of the animal species or its type of placenta [14]. Cytokines are also present in the chorioallantoic placenta of the three-toed skink Chalcides chalcides and in the yolk sac placenta of Mustelus canis [5,6,15]. …”

Section: Discussionmentioning

confidence: 99%

Potential role of interleukin-1 at the peri-ovulation stage in a species of placental viviparous reptile, the three-toed skink, Chalcides chalcides (squamata: scincidae)

Romagnoli

Cateni

Guarino

et al. 2003

Reprod Biol Endocrinol

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We recently showed that interleukin-1 (IL-1) is secreted by the placenta of a species of squamate reptile, the three-toed skink, Chalcides chalcides. In this study, we used immunohistochemical techniques to investigate the expression of IL-1 (in the two isoforms, IL-1α and IL-1β) and its specific membrane receptor IL-1 RtI in uterine oviduct during the peri-implantation period. We found that both IL-1 and its receptor were expressed in uterine tissues before and after ovulation (in the pre-ovulatory stage, even before the yolk had formed in the ovary). However, while IL-1α was mostly localized in the uterine mesenchyme tissue, IL-1β and IL-1RtI were present in the uterine epithelium. Our data provide a further comparison between the reproduction of mammals and squamate reptiles.

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Section: Discussionmentioning

confidence: 99%

Potential role of interleukin-1 at the peri-ovulation stage in a species of placental viviparous reptile, the three-toed skink, Chalcides chalcides (squamata: scincidae)

Romagnoli

Cateni

Guarino

et al. 2003

Reprod Biol Endocrinol

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“…A small number of cytokines and poor cytokine network are the characteristics of nonmammalian vertebrates. For example, cytokines like IL-10 and IL-4 are unknown in fishes and amphibians, but TGF- is evidenced in reptiles, birds and probably in other non-mammalian classes [23,24] . 10.…”

Section: Anti-tumor Immunity Failure In Mammalsmentioning

confidence: 99%

Comparative Oncology and Comparative Tumor Immunology

Bubanovic¹,

Najman²

2005

J. of Biological Sciences

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Abstract:Comparative oncology is a branch of comparative pathology that is relatively new biomedical discipline. The need for a comparative research into tumors across different groups of living beings has arisen from a relatively old notion that most of multicellular organisms may develop tumors. This apparently very simple fact indicate the possible nature of tumor growth, which can be associated with the basic features of the cells of multicellular organisms such as the division, development, growth and differentiation of cells and tissues. Regarding this, tumor growth is commonly defined as a fundamental disorder in the regulation of cell division, growth, differentiation and cell socialization. In all vertebrates, neoplasia is a disease in which genetically altered cells escape from the normal cell-cycle regulation and monitoring of the immune system. This results in a persistent, expanding or infiltrating growth without control and the architecture of the normal tissue. Concerning the facts that mechanisms of cell sociability control and anti-tumor immune monitoring might be different in different group of animals, especially, in different classes of vertebrates, development of disciplines such as comparative oncology and comparative tumor immunology can be of great scientific importance.

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“…A small number of cytokines and a poor cytokine network are characteristics of nonmammalian vertebrates. For example, cytokines such as IL-10 and TGF-β are unknown in fishes and amphibians, but TGF-β is evident in reptiles and birds (Paulesu, 1997;Reboul et al, 1999).…”

Section: Tumors In Mammals and Other Classes Of Vertebratesmentioning

confidence: 99%

Ideas in Theoretical Biology - Failure of Anti-Tumor Immunity in Mammals - Evolution of the Hypothesis

Bubanovic

Najman²

2004

Acta Biotheor

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Observations on the morphological and functional similarity between embryonic or trophoblast tissues and tumors are very old. Over a period of time many investigators have created different hypotheses on the origin of cancerogenesis or tumor efficiency in relation to the host immune system. Some of these ideas have been rejected but many of them are still current. A presumption of the inefficiency of anti-tumor immunity in mammals due to the high similarity between trophoblast and embryonic cells to tumor cells is very real. The mechanisms for the escape of tumors from the immune response are very similar to the mechanisms for the escape of a fetoplacental unit from the maternal immune response. The similarity between these two mechanisms is so great that any randomness must be banished. At the same time, an incidence of malignant tumors and the types of more frequent tumors in non-mammalian vertebrates is significantly different to that in mammals. Lastly, the mechanisms of anti-tumor immunity in mammals are substantially different from the mechanisms of anti-tumor immunity in other classes of vertebrates. These facts indicate that the immune system of mammals during anti-tumor immune response is tricked by the similarity between tumor cells and trophoblast or other placental cells. From this aspect, our conclusion is that anti-tumor immunity failure in mammals can be defined as an immunoreproductive phenomenon, which is developed under the evolutionary pressure of autoimmunity and reproductive effectiveness.

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Cytokines in mammalian reproduction and speculation about their possible involvement in nonmammalian viviparity

Cited by 30 publications

References 55 publications

Potential role of interleukin-1 at the peri-ovulation stage in a species of placental viviparous reptile, the three-toed skink, Chalcides chalcides (squamata: scincidae)

Potential role of interleukin-1 at the peri-ovulation stage in a species of placental viviparous reptile, the three-toed skink, Chalcides chalcides (squamata: scincidae)

Comparative Oncology and Comparative Tumor Immunology

Ideas in Theoretical Biology - Failure of Anti-Tumor Immunity in Mammals - Evolution of the Hypothesis

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