Cytokines in pleural liquid for diagnosis of tuberculous pleurisy

Yamaguchi, Yasuo; Nakamura, Atsushi; Hosoda, Masayoshi; Kato, Takashi; Asano, Tomoko; Tonegawa, Ken; Itoh, Makoto

doi:10.1053/rmed.2001.1103

Cited by 52 publications

(46 citation statements)

References 18 publications

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“…Our meta-analysis suggests that the ELISPOT assay may be more accurate than both other assays. One study (Gui and Xiao, 2014) (Yamada et al, 2001). Future studies should perform side-by-side comparisons of these three assays to determine whether they can be used interchangeably or whether one should be preferred over another.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis

Li¹,

Qin²,

Li³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Current methods for diagnosing tuberculous pleurisy are poor. Some studies have explored the diagnostic value of a pleural effusion enzyme-linked immunospot (ELISPOT) assay, but its accuracy remains controversial. Therefore, we performed a meta-analysis of the existing evidence on the ability of the ELISPOT assay to diagnose tuberculous pleurisy. We systematically searched PubMed, Google Scholar, and EMBASE databases for studies measuring the sensitivity, specificity, and other measures of accuracy of the pleural effusion ELISPOT assay for diagnosis of tuberculous pleurisy. A total of nine studies were identified and subjected to meta-analysis, giving the following pooled values for sufficiently accurate to diagnose tuberculous pleurisy as a stand-alone technique. In fact, it appears to be superior to assays based on adenosine deaminase and gamma interferon for screening patients and confirming the diagnosis of tuberculous pleurisy.

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Section: Discussionmentioning

confidence: 99%

Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis

Li¹,

Qin²,

Li³

et al. 2015

Genet. Mol. Res.

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“…Infections by other viruses, such as respiratory syncytial virus, induce IL-8 production (22), as do infections by bacteria or parasites, including Mycobacterium tuberculosis (35). The transcriptional regulation of IL-8 has also been shown in a range of inflammatory responses, including cancer (16), atherosclerosis (28), and arthritis (23).…”

Section: Discussionmentioning

confidence: 99%

Increased Production of Interleukin-8 in Primary Human Monocytes and in Human Epithelial and Endothelial Cell Lines after Dengue Virus Challenge

Bosch

Xhaja²,

Estevez³

et al. 2002

J Virol

136

113

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The more severe form of dengue virus infection, dengue hemorrhagic fever, is characterized by plasma leakage and derangements in hemostasis. As elevated interleukin-8 (IL-8) levels have been observed in sera from patients with more severe disease manifestations, a study was initiated to look at the effect of dengue virus infection in vitro on proinflammatory cytokine secretion and expression. A significant increase in IL-8 levels in the culture supernatant of primary human monocytes infected with dengue 2 virus (D2V) New Guinea C (NGC) was found by enzyme-linked immunosorbent assay. Additionally, by reverse transcriptase PCR, the mRNA was also augmented. Among the proinflammatory cytokines and their mRNAs measured (IL-6, IL-1␤, IL-8, and tumor necrosis factor alpha), IL-8 showed the greatest change following D2V infection. Similarly, two cell lines, 293T (a human epithelial cell line) and ECV304 (an endothelial cell line), were permissive to D2V NGC and responded to the infection by increasing the synthesis of IL-8. Nuclear factor kappa B (NF-B) and nuclear factor IL-6 (NFIL-6) are primary mediators of IL-8 expression. We studied the transcriptional regulation of IL-8 in the ECV304 and 293T cell lines and found that the induction of IL-8 gene expression involved the activation of NF-B (P ‫؍‬ 0.001) and, to a lesser extent, the activation of NFIL-6 in ECV304 cells only. We next observed by the chromatin immunoprecipitation procedure in vivo acetylation of core histones bound to the IL-8 promoter after D2V infection. IL-8 produced by infected monocytes and also IL-8 that may be produced by endothelial or other epithelial cells is associated with the hyperacetylation of histones bound to the IL-8 promoter in addition to the activation of transcription by NF-B. We hypothesize that the overall increase in IL-8 synthesis observed in this in vitro study may play a role in the pathogenesis of the plasma leakage seen in dengue hemorrhagic fever and dengue shock syndrome.

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“…We have also provided evidence that the SeV C proteins and leader RNA counteract the expression of the chemokine IL-8. Infections by other viruses, e.g., respiratory syncytial virus (RSV) (44), dengue virus (3), hepatitis C virus (49), and human immunodeficiency virus type 1 (46,52), are known to induce IL-8 secretion, as do infections by bacteria and parasites, including Mycobacterium tuberculosis (66). In a related vein, cytomegalovirus, a large DNA virus, encodes a chemokine receptor that may facilitate virus replication (13), and human herpesvirus 8/Kaposi's sarcoma virus carries four ORFs whose products are related to chemokines (42).…”

Section: Discussionmentioning

confidence: 99%

Sendai Virus Targets Inflammatory Responses, as Well as the Interferon-Induced Antiviral State, in a Multifaceted Manner

Strahle

Garcin

Mercier

et al. 2003

J Virol

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We have used cDNA arrays to compare the activation of various cellular genes in response to infection with Sendai viruses (SeV) that contain specific mutations. Three groups of cellular genes activated by mutant SeV infection, but not by wild-type SeV, were identified in this way. While some of these genes are well known interferon (IFN)-stimulated genes, others, such as those for interleukin-6 (IL-6) and IL-8, are not directly induced by IFN. The gene for beta IFN (IFN-␤), which is critical for initiating an antiviral response, was also specifically activated in mutant SeV infections. The SeV-induced activation of IFN-␤ was found to depend on IFN regulatory factor 3, and the activation of all three cellular genes was independent of IFN signaling. Mutations that disrupt four distinct elements in the SeV genome (the leader RNA, two regions of the C protein, and the V protein) all lead to enhanced levels of IFN-␤ mRNA, and at least three of these viral genes also appear to be involved in preventing activation of IL-8. Our results suggest that SeV targets the inflammatory and adaptive immune responses as well as the IFN-induced intracellular antiviral state by using a multifaceted approach.

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Cytokines in pleural liquid for diagnosis of tuberculous pleurisy

Cited by 52 publications

References 18 publications

Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis

Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis

Increased Production of Interleukin-8 in Primary Human Monocytes and in Human Epithelial and Endothelial Cell Lines after Dengue Virus Challenge

Sendai Virus Targets Inflammatory Responses, as Well as the Interferon-Induced Antiviral State, in a Multifaceted Manner

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