Cytokines in recurrent pregnancy loss

Daher, Sílvia; Denardi, Kátia de Arruda Geraldes; Blotta, Maria Heloı́sa Souza Lima; Mamoni, Ronei Luciano; Reck, Ana Paula Monteiro; Camano, Luiz; Mattar, Rosiane

doi:10.1016/j.jri.2003.10.004

Cited by 82 publications

(51 citation statements)

References 26 publications

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“…In man, IL-4 is thought to be necessary for the establishment and maintenance of pregnancy, by avoiding the harmful effects of cell-mediated immunity in the vicinity of putative embryo implantation sites and at the feto-maternal interface (Lin et al 1993, Piccinni 2005. Similarly, G-CSF, which participates in subsequent placental granulocytosis, can modulate the production of deleterious levels of IFN-g (which we report to be comparatively low in seminal fluid), which is known to impair human trophoblast cell growth and function in vitro and to cause abortion in mice (Sugita et al 2003; reviewed by Daher et al 2004). Seminal fluid and serum cytokines were expressed as ratios in order to further highlight their differences (Tables 3 and 4).…”

Section: Discussionmentioning

confidence: 61%

Multiplex determination of murine seminal fluid cytokine profiles

Gopichandran¹,

Ekbote²,

Walker³

et al. 2006

Reproduction

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Section: Discussionmentioning

confidence: 61%

Multiplex determination of murine seminal fluid cytokine profiles

Gopichandran¹,

Ekbote²,

Walker³

et al. 2006

Reproduction

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“…A highly coordinated chemokine network underlies not only different leukocyte subset recruitment but also orchestrates unique mechanisms of immunomodulation. [1][2][3][4][5] Trophoblast cells have a central role in the control of maternal immune homeostasis through modulating uterine NK cell activity, decidual macrophage polarization to an alternative profile, tolerogenic dendritic cell (DC) differentiation and induction of regulatory T cells (Tregs). [6][7][8] Following the inflammatory period characteristic of implantation, an anti-inflammatory and immune tolerant microenvironment is induced to sustain immune homeostasis and successful pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation

Ramhorst

Grasso

Paparini

et al. 2016

Cell Adhesion & Migration

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Chemokine network is central to the innate and adaptive immunity and entails a variety of proteins and membrane receptors that control physiological processes such as wound healing, angiogenesis, embryo growth and development. During early pregnancy, the chemokine network coordinates not only the recruitment of different leukocyte populations to generate the maternalplacental interface, but also constitutes an additional checkpoint for tissue homeostasis maintenance. The normal switch from a pro-inflammatory to an anti-inflammatory predominant microenvironment characteristic of the post-implantation stage requires redundant immune tolerance circuits triggered by key master regulators. In this review we will focus on the recruitment and conditioning of maternal immune cells to the uterus at the early implantation period with special interest on high plasticity macrophages and dendritic cells and their ability to induce regulatory T cells. We will also point to putative immunomodulatory polypeptides involved in immune homeostasis maintenance at the maternal-placental interface.

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“…10 Depending on the period of pregnancy, a predominant inflammatory profile defined by increased production of Th1 cytokines (such as interferon-gamma (IFN-G) and tumor necrosis factor-alpha (TNF-A)), may compromise the normal development of the concept, while an anti-inflammatory pattern characterized by increased production of Th2 cytokines (such as IL-4, IL-6 and IL-10) seems to favor a normal pregnancy outcomes. [11][12][13][14] Insulin resistance has been associated with abnormal secretion of pro-inflammatory cytokines such as TNF-A and interleukin (IL)-6 and decreased production of anti-inflammatory mediators such as IL-4 and IL-10. 7,15 Despite some controversies regarding specific cytokine levels, T2DM is currently regarded as a chronic inflammatory disease.…”

Section: Introductionmentioning

confidence: 99%

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Gomes

Torloni

Gueuvoghlanian-Silva

et al. 2013

American J Rep Immunol

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CitationGomes CP, Torloni MR, Gueuvoghlanian-Silva BY, Alexandre SM, Mattar R, Daher S. Cytokine levels in gestational diabetes mellitus: a systematic review of the literature. Am J Reprod Immunol 2013; 69: 545-557 doi:10.1111/aji.12088 Problem Gestational diabetes mellitus (GDM) is an inflammatory condition that involves unbalanced cytokine production. We carried out a systematic review on the relationship between GDM and maternal circulating levels of cytokines in the 2nd/3rd trimesters. Method of StudyThree electronic databases (MEDLINE, EMBASE and LILACS), were searched. Duplicate study selection, extraction and quality assessment was performed. ResultsTwenty-two studies with 1982 participants reporting levels of 9 cytokines (IL-1B, IL-2, IL-6, IL-10, IL-13, IL-18, IFN-G, TGF-B and TNF-A) were included. Most studies differed considerably in selection criteria, sampling and assay methods and in reporting their results. Consequently, only two studies could be pooled: TNF-A concentration was slightly higher in GDM than in control patients, although not significant (WMD = 0.45, 95% CI À0.34-1.23). ConclusionsNew studies with well-defined, more homogeneous methodological parameters are needed to detect whether there are significant differences in circulating levels of cytokines in patients with GDM.

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Cytokines in recurrent pregnancy loss

Cited by 82 publications

References 26 publications

Multiplex determination of murine seminal fluid cytokine profiles

Multiplex determination of murine seminal fluid cytokine profiles

Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

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