2001
DOI: 10.1006/cyto.2001.0922
|View full text |Cite
|
Sign up to set email alerts
|

Cytokines Modulate Endothelial Cell Intracellular Signal Transduction Required for Vcam-1-Dependent Lymphocyte Transendothelial Migration

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

4
96
0

Year Published

2003
2003
2018
2018

Publication Types

Select...
4
3

Relationship

2
5

Authors

Journals

citations
Cited by 47 publications
(100 citation statements)
references
References 70 publications
4
96
0
Order By: Relevance
“…Therefore, spleen cells (3 ϫ 10 6 ) were added to the flow chamber (3.5 cm 2 ) at 2 dynes/cm 2 . Spleen cells were added at concentrations below saturation of monolayer cell binding or migration (12,24). To initiate spleen cell contact with the endothelial cells in vitro, the spleen cells were allowed to settle in the chamber as monitored by microscopy and then 2 dynes/cm 2 was applied for the 15 min laminar flow assay.…”
Section: Cell Association and Migration Assays With Laminar Flowmentioning
confidence: 99%
See 3 more Smart Citations
“…Therefore, spleen cells (3 ϫ 10 6 ) were added to the flow chamber (3.5 cm 2 ) at 2 dynes/cm 2 . Spleen cells were added at concentrations below saturation of monolayer cell binding or migration (12,24). To initiate spleen cell contact with the endothelial cells in vitro, the spleen cells were allowed to settle in the chamber as monitored by microscopy and then 2 dynes/cm 2 was applied for the 15 min laminar flow assay.…”
Section: Cell Association and Migration Assays With Laminar Flowmentioning
confidence: 99%
“…Abs for other adhesion molecules other than VCAM-1 or its ligand ␣ 4 ␤ 1 integrin do not block lymphocyte migration across the endothelial cells (12). Therefore, the endothelial cell lines provide a model to examine signals during VCAM-1-dependent lymphocyte migration, while avoiding complexity from signals induced by lymphocyte binding to other adhesion molecules on endothelial cells (9,12,26,27). This is important so that signaling intermediates can be inhibited in the endothelial cells and then the functional consequence on VCAM-1-dependent migration examined.…”
mentioning
confidence: 94%
See 2 more Smart Citations
“…17,18 However, TGFb family members modulate many other B-and T-cell responses like cell adhesion, apoptosis or cytokine secretion. [19][20][21] At the cell surface, TGFb, Act or BMPs bind to a type II receptor, which recruits and phosphorylates a type I receptor to form a type I/type II receptor complex. 22 The activated type I receptor provides anchorage for receptor Smad proteins (R-Smads) and subsequently induces their phosphorylation.…”
Section: Introductionmentioning
confidence: 99%