Cytokines profile in patients with acute and chronic hepatitis B infection

Ribeiro, Camilla Rodrigues de Almeida; Beghini, Daniela Gois; Lemos, Andreza Sálvio; Martinelli, Katrini Guidolini; Mello, Vinicius M.; Almeida, Nathália Alves Araújo de; Lewis-Ximenez, Lia Laura; Paula, Vanessa Salete de

doi:10.1111/1348-0421.12947

Cited by 18 publications

(11 citation statements)

References 49 publications

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“…The analysis of acute hepatitis A, C, and E cases showed that the mean values of IL-6 in the acute phase were 61.6, 26.3, and 15.5 pg/mL, respectively, and those of TNF-α were 52.3, 22.8, and 61.6 pg/mL, respectively. Interestingly, in all the studies, the serum cytokine concentrations were significantly higher in patients with acute hepatitis than in normal participants [ 19 – 21 ]. In addition, two reports of Japanese patients with severe acute Epstein–Barr virus or cytomegalovirus infection accompanied by extreme liver dysfunction, described elevated serum IL-6 levels of 7.0 and 10.3 pg/mL, respectively, at the time of admission [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Histology and cytokine levels in hepatic injury accompanying a case of non-severe COVID-19

Matsuda

Nosaka

Hiramatsu

et al. 2023

Clin J Gastroenterol

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The pathogenesis of liver dysfunction that complicates coronavirus disease 2019 (COVID-19) remains unclear, especially in mild to moderate severity cases. In this case, a novel coronavirus infection was detected by polymerase chain reaction (PCR) in a 76-year-old woman hospitalized after presenting with fever. No other abnormal physical findings were observed, and oxygen administration was not required. Chest computed tomography (CT) showed a ground-glass-like and an infiltrative shadow in the right lung, and moderate COVID-19 was diagnosed. Initially, the fever resolved, and PCR turned negative; however, the fever reappeared on hospitalization day 14, and CT showed pneumonia exacerbation accompanied by new onset of fatty liver. Biochemical testing revealed marked liver dysfunction, accompanied by elevated serum interleukin (IL)-6, IL-10, and tumor necrosis factor-α levels. Physical findings and all laboratory parameters improved after conservative treatment, and she was discharged on day 22. A liver biopsy performed 44 days post-discharge showed T-cell-dominant inflammatory cell infiltration, mainly in the portal region. Some hepatocytes showed fatty degeneration. We report a case of moderate COVID-19 in which histological hepatitis persisted after a substantial period had passed since the initial infection had cleared and associated transaminase elevations had resolved, with a comparison of serum cytokine dynamics.

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Section: Discussionmentioning

confidence: 99%

Histology and cytokine levels in hepatic injury accompanying a case of non-severe COVID-19

Matsuda

Nosaka

Hiramatsu

et al. 2023

Clin J Gastroenterol

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“…In recent years, distorted cytokine expression has been found in acute and chronic hepatitis B patients ( Ribeiro et al, 2022 ). Our study found that CXCL8 was disregulated in HBV infection.…”

Section: Discussionmentioning

confidence: 99%

“…In HBV infection, ALT conveys limited information, which can only indicate the liver injury caused by viral factors. However, the result of HBV infection is not only dependent on viral factors, but also related to host factors, such as the immune response of the body ( Ribeiro et al, 2022 ). CXCL8, CXCL9, CXCL10, and CXCL11 can recruit immune cells to the site of inflammation to play a role in clearing pathogens.…”

Section: Discussionmentioning

confidence: 99%

CXCL8, CXCL9, CXCL10, and CXCL11 as biomarkers of liver injury caused by chronic hepatitis B

Chen

Cui

et al. 2022

Front. Microbiol.

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BackgroundChronic hepatitis B (CHB) remains a significant global health problem, leading to recurrent inflammation and liver-damaging diseases such as fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Currently, although diagnostic markers for CHB are well established, the indicators for predicting liver injury caused by hepatitis B virus (HBV) infection still need to be further explored. Thus, the identification of credible infectious indicators is urgently needed to facilitate timely clinical intervention and avoid the progression of disease malignancy.MethodsThe Gene Expression Omnibus (GEO) database GSE83148 data set was used to explore the hub genes for HBV infection. The quantitative real-time polymerase chain reaction (qPCR) was used to identify the impact of HBV infection on the expression of hub gene at the cell level. At the same time, serum samples and clinical information were collected from healthy, HBV-free and CHB patients. The enzyme-linked immunosorbent assay (ELISA) was used to verify the results of cell experiments and Pearson correlation analysis was used to clarify hub genes correlation with HBV infection indicators and liver injury-related indicators. Finally, the Gene Expression Profiling Interactive Analysis (GEPIA) database was used to analyze the differences in the expression of hub gene in liver injury diseases.ResultsChemokine (C-X-C motif) ligand (CXCL)8, CXCL9, CXCL10, and CXCL11 were identified as hub genes in HBV infection. After HBV infection, the expression of the four chemokines was significantly increased and the concentrations secreted into serum were also increased. Moreover, the four chemokines were significantly correlated with HBV infection-related indicators and liver injury-related indicators, which were positively correlated with alanine aminotransferase (ALT), aspartate aminotransferase (AST) and hepatitis B e antigen (HBeAg), and negatively correlated with AST/ALT ratio and hepatitis B core antibody (HBcAb). In addition, the expression of CXCL9, CXCL10, and CXCL11 in HCC tissues was significantly higher than in normal tissues.ConclusionUsing a combination of bioinformatics, cell experiments, and clinical correlation analysis, this study showed that CXCL8, CXCL9, CXCL10, and CXCL11 can be used as serum biomarkers to forecast liver injury caused by HBV infection.

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“…Viremia lasting for 6 months or more, is considered persistent HCV infection. 115 , 116 HCV uses a variety of methods to evade the immune system, resulting in immune system evasion and infection persistence. 117 T cell function is lost in chronic T cell stimulation, which is the first main mechanism of chronic infection.…”

Section: Immunopathogenesis Of Hcvmentioning

confidence: 99%

“…However, the decline of the CD4 + T cell activity specific to HCV is closely linked to the transition of acute infection of HCV into the chronic HCV infection. 116 Moreover, inadequacy and the subsequent reduction in a strong CD4 + T cell activity following acute infection have been documented and linked to chronic infection. 119 HCV escape mutations for individuals having multiple HLA epitopes (plus the HLA-DRB1*15 epitope) have been hypothesized as one route which decreases the CD4 + T cell activity.…”

Section: Immunopathogenesis Of Hcvmentioning

confidence: 99%

Epidemiology, risk factors, and pathogenesis associated with a superbug: A comprehensive literature review on hepatitis C virus infection

et al. 2022

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Viral hepatitis is a major public health concern. It is associated with life threatening conditions including liver cirrhosis and hepatocellular carcinoma. Hepatitis C virus infects around 71 million people annually, resultantly 700,000 deaths worldwide. Extrahepatic associated chronic hepatitis C virus accounts for one fourth of total healthcare load. This review included a total of 150 studies that revealed almost 19 million people are infected with hepatitis C virus and 240,000 new cases are being reported each year. This trend is continually rising in developing countries like Pakistan where intravenous drug abuse, street barbers, unsafe blood transfusions, use of unsterilized surgical instruments and recycled syringes plays a major role in virus transmission. Almost 123–180 million people are found to be hepatitis C virus infected or carrier that accounts for 2%–3% of world’s population. The general symptoms of hepatitis C virus infection include fatigue, jaundice, dark urine, anorexia, fever malaise, nausea and constipation varying on severity and chronicity of infection. More than 90% of hepatitis C virus infected patients are treated with direct-acting antiviral agents that prevent progression of liver disease, decreasing the elevation of hepatocellular carcinoma. Standardizing the healthcare techniques, minimizing the street practices, and screening for viral hepatitis on mass levels for early diagnosis and prompt treatment may help in decreasing the burden on already fragmented healthcare system. However, more advanced studies on larger populations focusing on mode of transmission and treatment protocols are warranted to understand and minimize the overall infection and death stigma among masses.

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Cytokines profile in patients with acute and chronic hepatitis B infection

Cited by 18 publications

References 49 publications

Histology and cytokine levels in hepatic injury accompanying a case of non-severe COVID-19

Histology and cytokine levels in hepatic injury accompanying a case of non-severe COVID-19

CXCL8, CXCL9, CXCL10, and CXCL11 as biomarkers of liver injury caused by chronic hepatitis B

Epidemiology, risk factors, and pathogenesis associated with a superbug: A comprehensive literature review on hepatitis C virus infection

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