Cytokinetic engineering enhances the secretory production of recombinant human lysozyme in Komagataella phaffii
Yong-Jun Zhong,
Yang-Yang Luo,
Haiyang Xia
et al.
Abstract:Background
Human lysozyme (hLYZ) is a natural antibacterial protein with broad applications in food and pharmaceutical industries. Recombinant production of hLYZ in Komagataella phaffii (K. phaffii) has attracted considerable attention, but there are very limited strategies for its hyper-production in yeast.
Results
Here through Atmospheric and Room Temperature Plasma (ARTP)-based mutagenesis and transcriptomic analysis, the expression of two genes… Show more
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