1973
DOI: 10.1111/j.1365-2184.1973.tb01605.x
|View full text |Cite
|
Sign up to set email alerts
|

Cytokinetics of the S‐180 Ascites Tumor System

Abstract: The cytokinetics of the S‐180 mouse ascites tumor system was determined on Days 2, 4, 6 and 9 of growth. Studies included volume tumor growth, per cent labeled mitoses curves, and repeated injections of tritiated thymidine. It was possible to extrapolate the cytokinetic compartment values to Day 0 of growth. Results indicate that the growth fraction of the S‐180 system remains close to 1 throughout its growth, with progressive lengthening of G1, S and G2 times. Cell loss is minimal through 6 days but becomes s… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
4
0

Year Published

1976
1976
2019
2019

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 9 publications
(4 citation statements)
references
References 3 publications
0
4
0
Order By: Relevance
“…The regulation can be carried out through changes in the phases of the cell cycle (as is often the case in ascites tumours (see for example Schiffer et al, 1973;and Dombernowsky et a]., 1973) or through transfer of cells into a resting phase (Go-phase, see Epifenova and Terskikh, 1969). In terms of recent cell cycle models, the regulation might be carried out through a changing probability for entrance into the determinate phase, which mainly consists of the S and the G,-phase (Burns and Tannock, 1970;Smith and Martin, 1973).…”
Section: Discussionmentioning
confidence: 99%
“…The regulation can be carried out through changes in the phases of the cell cycle (as is often the case in ascites tumours (see for example Schiffer et al, 1973;and Dombernowsky et a]., 1973) or through transfer of cells into a resting phase (Go-phase, see Epifenova and Terskikh, 1969). In terms of recent cell cycle models, the regulation might be carried out through a changing probability for entrance into the determinate phase, which mainly consists of the S and the G,-phase (Burns and Tannock, 1970;Smith and Martin, 1973).…”
Section: Discussionmentioning
confidence: 99%
“…Earlier reports on other ascitic tumor lines about the apparent elongation of the cell cycle with tumor age may be ac counted for by the incorporation of 3 resting stales: G0, Q, and Q". Accumulation of Gn cells will elongate G, [21. 301; reentry of Qj to the cycle will elongate S [54|; and reentry of Q2 will elongate M [41,47], The dashed line from Q2 through M indicates that when Q" cells are fed back into the cycle, they undergo only one mitosis and will give rise to two Tr daughter cells. Cell loss through either emi gration or death can occur from any phase or stage in the model.…”
Section: Cell Compartments and Differential Countsmentioning
confidence: 99%
“…When injected into the peritoneal cavity, S180 cells grow exponentially with a generation time of 12-18 h (10). Growing primarily in suspension in the peritoneal cavity, S180 cells gradually plug peritoneal lymphatic drainage, leading to accumulation of ascites fluid within 2 weeks.…”
mentioning
confidence: 99%