Cytologic and histologic samples from patients infected by the novel coronavirus 2019 SARS‐CoV‐2: An Italian institutional experience focusing on biosafety procedures

Rossi, Esther Diana; Fadda, Guido; Mulè, Antonino; Zannoni, Gian Franco; Rindi, Guido

doi:10.1002/cncy.22281

Cited by 33 publications

(53 citation statements)

References 9 publications

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“…Children under the age of 9 have a mild course in nearly all cases although a new kind of disease entity during the COVID-19 period has been observed which resembles Kawasaki disease [24] . Postmortem research revealed that tissue responses to SARS-CoV-2 infection are distinct in different organs [25] , [26] . In comparison with observations made during the SARS-CoV-1 and MERS outbreaks, SARS-CoV-2 has similarities in risk group spread, but the case fatality rate of SARS-CoV-2 appears to be lower [2] .…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 and cancer: Are they really partners in crime?

Dam

Huizing

Mestach

et al. 2020

Cancer Treatment Reviews

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Highlights Cancer patients with COVID-19 have a higher morbidity and mortality. Particularly patients with ongoing or recent cancer treatment, metastatic solid tumors and hematological malignancies are at risk. Underlying immunosuppression, elevated cytokine levels, altered expression of the angiotensin converting enzyme (ACE-2) and TMPRSS2, and a prothrombotic status in cancer patients may fuel the effects of a SARS-CoV-2 sepsis. The gene expression level of ACE2 may be an indicator of the susceptibility to SARS-CoV-2 infection, while TMPRSS2 plays a supporting role. Better knowledge of the mechanisms involved may be a tool to identify high risk patients and to prevent severe complications by targeting the involved pathways.

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Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 and cancer: Are they really partners in crime?

Dam

Huizing

Mestach

et al. 2020

Cancer Treatment Reviews

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show abstract

“…Besides, another study revealed that formalin and glutaraldehyde can deactivate SARS-CoV depending on the temperature and time [9] . Rossi et al, [33] also recommend that histological tissues should stay for extended periods of formaldehyde fixation. On the contrary, Odega et al, [34] kicked against performing frozen sections on suspected coronavirus tissues except such a laboratory is assertive of restraining aerosols in the cryostat.…”

Section: Coronavirus Disease 2019 (Covid-19) and Sourcing Of Cadaversmentioning

confidence: 99%

Post-COVID-19 pandemic: Standard operating procedures for gross anatomy laboratory in the new standard

et al. 2021

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Highlights COVID-19 pandemic has affected medical education and practice due to the closure of schools globally. Most medical schools and educators are concerned about the safety of cadavers for dissection during the COVID-19 pandemic. There is currently no proof of people being infected due to exposure to COVID-19 dead bodies. Common fixatives are viable against COVID-19 depending on time and temperature. Standard operating procedures must be followed when handling dead bodies during and after the COVID-19 pandemic. COVID-19 pandemic could be a pointer for the full incorporation of technology in the Anatomy and medical curriculum.

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“…Infection by droplets contaminating hands and surfaces are the foremost means of dispersal of the virus [29]. GI tract is also a plausible spreading pathway and target organ of SARS-CoV-2 [30].…”

Section: Transmissionmentioning

confidence: 99%

The Pathophysiology, Diagnosis and Treatment of Corona Virus Disease 2019 (COVID-19)

Das

2020

Ind J Clin Biochem

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Since the beginning of this century, beta coronaviruses (CoV) have caused three zoonotic outbreaks. However, little is currently known about the biology of the newly emerged SARS-CoV-2 in late 2019. There is a spectrum of clinical features from mild to severe life threatening disease with major complications like severe pneumonia, acute respiratory distress syndrome, acute cardiac injury and septic shock. The genome of SARS-CoV-2 encodes polyproteins, four structural proteins and six accessory proteins. SARS-CoV-2 tends to utilize Angiotensin-converting enzyme 2 (ACE2) of various mammals. The imbalance between ACE/Ang II/AT1R pathway and ACE2/Ang(1-7)/Mas receptor pathway in the renin-angiotensin system leads to multi-system inflammation. The early symptoms of COVID-19 pneumonia are low to midgrade fever, dry cough and fatigue. Vigilant screening is important. The diagnosis of COVID-19 should be based on imaging findings along with epidemiological history and nucleic acid detection. Isolation and quarantine of suspected cases is recommended. Management is primarily supportive, with newer antiviral drugs/vaccines under investigation. Keywords Angiotensin Á Angiotensin converting enzyme Á Chloroquine Á Corona virus Á COVID-19 Á Cytokine storm Á RNA-dependent Á RNA polymerase Á Spike protein Á SARS-CoV2

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Cytologic and histologic samples from patients infected by the novel coronavirus 2019 SARS‐CoV‐2: An Italian institutional experience focusing on biosafety procedures

Cited by 33 publications

References 9 publications

SARS-CoV-2 and cancer: Are they really partners in crime?

SARS-CoV-2 and cancer: Are they really partners in crime?

Post-COVID-19 pandemic: Standard operating procedures for gross anatomy laboratory in the new standard

The Pathophysiology, Diagnosis and Treatment of Corona Virus Disease 2019 (COVID-19)

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