Cytologic and Immunoenzymatic Findings in CSF from Patients with Tick-Borne Encephalitis

Jeren, Tatjana; Vince, Adriana

doi:10.1159/000331611

Cited by 20 publications

(8 citation statements)

References 2 publications

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“…Clinical presentation and laboratory findings in TBE have been well studied but the knowledge on the local immune responses in this disease is limited (3)(4)(5)(6)(7). This study focuses on the analysis of cytokines and lymphocyte subpopulations in the cerebrospinal fluid (CSF) of TBE patients.…”

Section: Tick-borne Encephalitis Is a Viral Infection Of The Central mentioning

confidence: 99%

Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis

Lepej¹,

Mišić-Majerus²,

Jeren³

et al. 2007

Acta Neurol Scand

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Section: Tick-borne Encephalitis Is a Viral Infection Of The Central mentioning

confidence: 99%

Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis

Lepej¹,

Mišić-Majerus²,

Jeren³

et al. 2007

Acta Neurol Scand

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“…CSF findings in spotted fever group rickettsial disease are diverse: pleocytosis with predominant polymorphs (as in this case), predominance of eosinophils or predominance of lymphocytes. CSF may also be unremarkable [4,[7][8][9][10]. The predominant cell type in CSF may be related to the timing of CSF analysis; a report on tick-borne encephalitis showed an average of 570 cells with 60% polymorphs in the first three days of illness, and a predominance of mononuclear cells from the fifth day onwards [9].…”

Section: Discussionmentioning

confidence: 99%

Characterization of rickettsia rickettsii in a case of Fatal Brazilian spotted fever in the city of Rio de Janeiro, Brazil

Lamas¹,

Favacho²,

Rozental³

et al. 2008

Braz J Infect Dis

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A lethal case of Brazilian spotted fever (BSF) is presented. Clinical features were initially of gastrointestinal involvement and evolved with progression to septic shock, meningoencephalitis and death on the 6 th day of illness. Indirect immunofluorescence assay (IFA) for spotted fever group rickettsia (SFGR) was non-reactive. Diagnosis was confirmed by the polymerase chain reaction (PCR) and the nucleotide sequencing of a fragment of the ompA gene showed 100% homology to Rickettsia rickettsii. BSF has not been reported in the city of Rio de Janeiro in the last three decades, and the present description should alert the clinicians to its presence in urban Rio de Janeiro, and to the differential diagnosis with dengue fever, gastroenteritis, leptospirosis and bacterial septic shock, among others. Key-Words: Brazilian spotted fever, spotted fever group rickettsia, Rickettsia rickettsii, lethal case, Rio de Janeiro city, indirect immunofluorescence, polymerase chain reaction, central nervous system involvement.Brazilian spotted fever (BSF) is a systemic disease caused by Rickettsia rickettsii, a bacterium transmitted by the horse tick Amblyomma cajennense. It is endemic in the Southeast of Brazil (Rio de Janeiro, São Paulo, Minas Gerais and Espírito Santo states) and affects exposed children and adults [1][2][3][4]. Case presentation mimics several conditions which are endemic in the area, such as dengue fever, leptospirosis, gastroenteritis, meningococcal meningits and severe sepsis [1][2][3][4]. This paper reports a fatal case of BSF, occurring in July, in the metropolitan area of Rio de Janeiro, with prominent sepsis, rash and neurological and cerebrospinal fluid (CSF) findings. Case ReportA 48 year-old white male presented, six days prior to hospital admission, with acute onset of high-grade fever, myalgia, headache, nausea, vomiting and diarrhea. He was a heavy smoker, but past medical history was otherwise unremarkable. He sought medical attention and was treated symptomatically. Two days later his symptoms persisted and he developed jaundice: he was given sulfamethoxazole-trimethoprim and was sent home. The following day he sought the Emergency ward because of hematemesis and melena; he was oliguric. He was transferred to an infectious diseases reference hospital with the presumptive diagnosis of leptospirosis. He was a porter in the north area of Rio de Janeiro, and had frequent contact with rodents. He had been bitten by ticks in Campo Grande (west area of Rio Janeiro) two weeks previously, while visiting his brother, who was a horse cart driver. On arrival he was jaundiced, in deep coma with no neck stiffness, systolic blood pressure was 60 mmHg, heart rate =128 bpm, and a generalized purpuric rash was noted. He was intubated, mechanically ventilated, given rapid intravenous fluid, noradrenaline, ceftriaxone, oxacillin and chloramphenicol. Myoclonus was observed, and two hours after admission he presented a generalized tonic-clonic seizure. Initial investigation showed leukocytosis (18,200 cells/mm 3 , di...

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“…9 The fresh samples were centrifuged for five minutes at 700 rpm in a cytocentrifuge (Cytospin 3, Shandon, Runcorn, Cheshire, U.K.). The sediments were stained with May-Grünwald-Giemsa stain.…”

Section: Materials and Methods Cytologymentioning

confidence: 99%

“…DNA was isolated from Giemsastained sediments of pleural fluid as described previously. 9 The quality of DNA preparation was checked by amplification of a segment of β-globin gene (110 base pair [bp]) using PCO3 (5'-ACACAACTGT-GTTCACTAGC) and PCO4 (5'-CAACTTCATC-CACGTTCACC) primers, as described previously. 14 For HHV-8 DNA detection, primer pair KS-A (5'-CGTCGGTCGTGTCGTGTGAT) and KS-B (5'-GCATAATGTCTTCCTTGTGG), amplifying a 225-bp sequence within open reading frame 25, were used, as described previously.…”

Section: Immunophenotypingmentioning

confidence: 99%

AIDS-Related Body Cavity–Based Lymphoma

Vince

Begovać²,

Kessler³

et al. 2001

Acta Cytologica

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Cytologic and Immunoenzymatic Findings in CSF from Patients with Tick-Borne Encephalitis

Cited by 20 publications

References 2 publications

Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis

Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis

Characterization of rickettsia rickettsii in a case of Fatal Brazilian spotted fever in the city of Rio de Janeiro, Brazil

AIDS-Related Body Cavity–Based Lymphoma

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