Cytologic Characteristics of Endocrine Ductal Carcinoma in &lt;i&gt;Situ&lt;/i&gt; of the Breast

Yin, Hao; Schinella, Roger

doi:10.1159/000327062

Cited by 9 publications

(11 citation statements)

References 8 publications

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“…Previous authors concluded that SPC was closely related to mucinous carcinoma 1,12,13,21-23 because SPC were frequently associated with mucinous carcinoma and >50% of the pure-type mucinous carcinomas exhibited neuroendocrine differentiation. 1,12,13,22,25 In the present series, however, neuroendocrine carcinoma without mucinous differentiation was the most frequent type of invasive cancer. The incidence of mucinous carcinoma at Seirei Hamamatsu General Hospital and Seirei Numazu Hospital was 4.4% and 4.3%, respectively.…”

Section: Discussioncontrasting

confidence: 46%

“…And invasive neuroendocrine carcinoma, the most common type of invasive cancer associated with SPC in the present patients, seemed to be classified to a solid variant of neuroendocrine carcinoma in this WHO classification 10 . Some other authors classified tumors with the same morphological features as that of SPC as endocrine variant of DCIS 11–13 . But we adopted the terminology of SPC because we thought the solid and papillary intraductal growth pattern was the most important morphological feature for the histological diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…10 Some other authors classified tumors with the same morphological features as that of SPC as endocrine variant of DCIS. [11][12][13] But we adopted the terminology of SPC because we thought the solid and papillary intraductal growth pattern was the most important morphological feature for the histological diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Fourteen patients (1-9, 14,15,17-19) seen at Seirei Hamamatsu General Hospital between January 1993 and February 2006 were selected. Cases 12,13,16, and 20 were submitted by Seirei Numazu Hospital, case 10 was submitted by Iwata City Hospital, and case 11 was submitted by Seirei Mikatahara General Hospital. All the patients were Japanese women between the ages of 31 and 80 years (mean age, 66.0 years).…”

Section: Methodsmentioning

confidence: 99%

“…Fifteen patients had invasive cancers associated with SPC. The invasive cancer area ranged from <5% (minimal invasion) to 60% of the entire tumor area (patients 1-5,8-10, [12][13][14][15]17,18,20). The histological types of invasive cancers were mucinous carcinoma in five cases (patients 10,12,13,15,20) and neuroendocrine cell carcinoma, exhibiting the same cytological features as SPC, in 10 cases (patients 1-5,8,9,14,17,18; Fig.…”

Section: Pathological Findingsmentioning

confidence: 99%

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Solid–papillary carcinoma of the breast: Clinicopathological study of 20 cases

Otsuki¹,

Yamada²,

Shimizu³

et al. 2007

Pathology International

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The purpose of the present paper was to evaluate the clinicopathological and biological features of 20 Japanese patients with solid-papillary carcinoma of the breast (SPC) or SPC associated with invasive breast cancer. All the patients were Japanese women, including two sisters. The mean age was 66.0 years. The incidence of SPC among all the breast cancers treated at two institutions was 1.1% and 1.7%, respectively. The mean disease-free interval was 4 years 11 months. Axillary lymph node metastasis or tumor recurrence did not occur in any of the cases. Fifteen cases of SPC contained invasive cancers that ranged from <5% to 60% of the entire tumor area. Histological types of invasive cancers were mucinous carcinoma in five cases and neuroendocrine cell carcinoma in 10 cases. These results indicate that SPC is a potential precursor lesion for neuroendocrine carcinoma as well as mucinous carcinoma. When all the cases were classified and analyzed according to both the 2002 tumor node metastasis (TNM) classification system and the Nottingham histological grade, SPC patients, even those with invasive cancers, seemed to have longer disease-free survival compared to patients with the other invasive breast cancers of matching grade and stage. Clinicopathologically, SPC could be regarded as a separate type of ductal carcinoma in situ.

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Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Pathological Findingsmentioning

confidence: 99%

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Solid–papillary carcinoma of the breast: Clinicopathological study of 20 cases

Otsuki¹,

Yamada²,

Shimizu³

et al. 2007

Pathology International

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Metastatic mammary carcinomas with endocrine features: Potential diagnostic pitfalls

2005

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Mammary carcinomas with endocrine differentiation (MCED) are an uncommon subtype of breast carcinomas that are morphologically indistinguishable from low-grade endocrine neoplasms arising in other organs. Aspirates of MCED yield relatively monotonous cells with eccentrically placed nuclei containing characteristic "salt and pepper" chromatin. In the breast, these features represent MCED. In extramammary sites, the differential is more extensive, and diagnosing MCED metastases to the lung, a common location for primary and metastatic endocrine tumors, can be a challenging task, with significant clinical implications. Although primary MCED have been described extensively in the cytology literature, secondary pulmonary MCED have not been reported to the best of our knowledge. We report three cases of MCED metastatic to the lung and present the cytological and immunohistochemical features.

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Cytological study of 20 cases of solid‐papillary carcinoma of the breast

Yamada

Otsuki

Shimizu

et al. 2007

Diagnostic Cytopathology

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Solid-papillary carcinoma (SPC) of the breast is a rare variant of low-grade intraductal carcinoma but there are few cytological studies. We examined 20 cases of SPC of the breast, aged 31-80 (mean age 66.0 yr), to define the cytological features. In each of the cytological specimens, we could find both malignant and benign cytological features; the former were characterized by hypercellularity, highly discohesive clusters, numerous isolated cells, and severe overcrowding cells, while the latter were marked by small and bland nuclei, a low nuclear-cytoplasmic ratio, and inconspicuous nucleoli. Neither abnormal naked nuclei of tumor cell origin nor oval naked nuclei of myoepithelial cell origin were seen. We also reviewed the cytological findings of SPC as well as neuroendocrine carcinomas with intraductal components that had been reported and we concluded that the coexistence of malignant and benign features was the most characteristic cytological feature of SPC.

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Cytologic Characteristics of Endocrine Ductal Carcinoma in <i>Situ</i> of the Breast

Cited by 9 publications

References 8 publications

Solid–papillary carcinoma of the breast: Clinicopathological study of 20 cases

Solid–papillary carcinoma of the breast: Clinicopathological study of 20 cases

Metastatic mammary carcinomas with endocrine features: Potential diagnostic pitfalls

Cytological study of 20 cases of solid‐papillary carcinoma of the breast

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