Cytologic Correlates of Cervical Papillomavirus Infection

Ward, Benjamin D.; Burkett, Barbara; Petersen, Christine; Nuckols, Margaret L.; Brennan, Constance; Birch, Linda; Crum, Christopher P.

doi:10.1097/00004347-199010000-00001

Cited by 26 publications

(12 citation statements)

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“…It is then hypothesised that infected cells are present on the slides but do not always show sufficient morphologic anomalies to be recognised. This concept is supported in the literature (Ward et al, 1990;Cramer et al, 1997;Salvia et al, 2004).…”

Section: Contribution Of Hpv Viral Load Studysupporting

confidence: 61%

The probability for a Pap test to be abnormal is directly proportional to HPV viral load: results from a Swiss study comparing HPV testing and liquid-based cytology to detect cervical cancer precursors in 13 842 women

Bigras¹,

Marval²

2005

Br J Cancer

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In a study involving 13 842 women and 113 gynaecologists, liquid-based cytology and HPV testing for detecting cervical cancer were compared. A total of 1334 women were found to be positive for one or both tests and were invited for colposcopy with biopsy. A total of 1031 satisfactory biopsies on 1031 women were thereafter collected using a systematic biopsy protocol, which was random in the colposcopically normal-appearing cervix or directed in the abnormal one. In all, 502 women with negative tests were also biopsied. A total of 82 histologic high-grade squamous intraepithelial lesion (HSIL) were reported in biopsies, all from the group with one or both tests positive. Sensitivity and specificity to detect histologic HSIL were 59 and 97% for cytology, and 97 and 92% for HPV. In total, 14% of reviewed negative cytological preparations associated with histologic HSIL contained no morphologically abnormal cells despite a positive HPV test. This suggested a theoretical limit for cytology sensitivity. HPV viral load analysis of the 1143 HPVpositive samples showed a direct relationship between abnormal Pap test frequency and HPV viral load. Thus, not only does the HPV testing have a greater sensitivity than cytology but the probability of the latter being positive can also be defined as a function of the associated HPV viral load.

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Section: Contribution Of Hpv Viral Load Studysupporting

confidence: 61%

The probability for a Pap test to be abnormal is directly proportional to HPV viral load: results from a Swiss study comparing HPV testing and liquid-based cytology to detect cervical cancer precursors in 13 842 women

Bigras¹,

Marval²

2005

Br J Cancer

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“…3,4,8 The probability of finding direct evidence of HPV infection in cervical SILs decreases proportionally to the degree of dyskaryosis, reaching low levels in CIN 3. 1,7 HPV infection does occur in the absence of koilocytosis.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Infection in Atrophic Smears

Luzzatto¹,

Poli²,

Recktenvald³

et al. 2000

Acta Cytologica

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“…However, this does not necessarily refute the potential importance of these nucleic acid sequences. Nuovo found that a large number of HPV-related lesions contain more than one HPV type when analyzed by polymerase chain reaction, even though only one HPV type could be detected by in situ hybridization (87 women who are HPV DNA positive will uncover significant cytological abnormalities in 15 to 20% which were missed on the first analysis (69,125). Thus, if careful quality control is not performed, there is the possibility that lesions missed (or not sampled cytologically) and then subsequently discovered will be misinterpreted as having "progressed."…”

Section: Pathobiology Of Hpv-related Neoplasiamentioning

confidence: 99%

“…Because of the way in which the screening protocols are structured (i.e., around the Papanicolaou smear), the potential value of widespread HPV testing is limited to complementing the Papanicolaou smear and reducing false-negatives (30,69,125). Assuming that more sophisticated approaches to Papanicolaou smear interpretation (e.g., with computerized image analysis) may accomplish the above, HPV DNA testing as currently used will have questionable value, particularly given the uncertain predictive value of HPV DNA positivity for disease incidence.…”

Section: Epidemiological Discrepancies and Practical Limitationsmentioning

confidence: 99%

Pathobiology of papillomavirus-related cervical diseases: prospects for immunodiagnosis

1991

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In recent years, the relationship between human papillomaviruses (HPV) and genital neoplasia has been explored intensively, and a molecular basis for the role of HPV in the genesis of these diseases has been convincingly demonstrated. These findings have provided justification for efforts to apply this molecular information to the early detection and possible prevention of HPV-related neoplasia. The technology of detecting viral nucleic acids in genital fluids brought with it initial hopes that it would serve to identify women at risk for having or developing precancers or cancers of the cervix. Subsequent studies, however, have demonstrated limitations of the technology for predicting future disease. Recently, molecular immunology has complemented these prior efforts, with the intent to identify serological indices of exposure to HPV and perhaps delineate individuals at risk. The molecular basis for this approach, its limitations, and future prospects for immunodiagnosis are the subject of this review.

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Cytologic Correlates of Cervical Papillomavirus Infection

Cited by 26 publications

References 0 publications

The probability for a Pap test to be abnormal is directly proportional to HPV viral load: results from a Swiss study comparing HPV testing and liquid-based cytology to detect cervical cancer precursors in 13 842 women

The probability for a Pap test to be abnormal is directly proportional to HPV viral load: results from a Swiss study comparing HPV testing and liquid-based cytology to detect cervical cancer precursors in 13 842 women

Human Papillomavirus Infection in Atrophic Smears

Pathobiology of papillomavirus-related cervical diseases: prospects for immunodiagnosis

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