Cytologic diagnosis of acinic-cell carcinoma of salivary glands

Nagel, Holger; Laskawi, R.; Büter, Johann Jürgen; Schröder, M.; Chilla, R; Droese, M

doi:10.1002/(sici)1097-0339(199705)16:5<402::aid-dc5>3.0.co;2-d

Cited by 75 publications

(63 citation statements)

References 35 publications

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“…16,17 Similarly, it has recently been shown that mammary analogue secretory carcinoma has similar cytomorphology but with more multivacuolated cytoplasm, in contrast to the granular cytoplasm of acinic cell carcinoma. 18 Oncocytoid neoplasm with coarsely granular/vacuolated cytoplasm was therefore designed as a special category in our system, in the hopes of capturing these two entities, and was expected to have a significant risk of malignancy.…”

Section: Discussionmentioning

confidence: 96%

Salivary Gland Tumor Fine-Needle Aspiration Cytology

Griffith

Pai

Schneider

et al. 2015

American Journal of Clinical Pathology

126

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Objectives Fine-needle aspiration (FNA) is useful in the evaluation of salivary gland tumors, but currently no standard terminology or risk stratification model exists. Methods FNA smears were reviewed and categorized based on cytonuclear features, stromal characteristics, and background characteristics. Risk of malignancy was calculated for each category. Classifications as benign, neoplasm of uncertain malignant potential (NUMP), suspicious for malignancy, and positive for malignancy were used to aggregate categories into similar risk groups. Results Categorization of salivary gland aspirates into morphologic categories resulted in the expected risk stratification. Grouping of categories maintained risk stratification, providing classes with malignancy risk as follows: benign, 2%; NUMP, 18%; suspicious for malignancy, 76%; and positive for malignancy, 100%. Conclusions Salivary gland FNA categorization into commonly encountered morphologic categories provides risk stratification, which translates to a simplified classification scheme of benign, NUMP, suspicious, and positive for malignancy similar to the paradigm in other organ systems.

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Section: Discussionmentioning

confidence: 96%

Salivary Gland Tumor Fine-Needle Aspiration Cytology

Griffith

Pai

Schneider

et al. 2015

American Journal of Clinical Pathology

126

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“…In ACC-PCV, cell dissociation is sparse and acinar structures and bare tumor cell nuclei are missing. On the other hand, numerous small and large papillary groups and monolayered sheets of moderately pleomorphic tumor cells have been described [1,2,8].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of a case of papillary-cystic variant of acinic-cell carcinoma on fine needle aspiration cytology: Myriad of cytomorphological features

Narayan¹,

Jeyachandran²,

Parthiban³

et al. 2014

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.

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“…Standard MR imaging sequences were obtained: spin-echo T1-weighted images [500/ (11)(12)(13)(14)(15), repetition time/echo time, ms/ms]; T2-weighted images [(5000-5500)/(102-110)]. The section thickness was 5.0 mm with an intersection gap of 1.0 mm.…”

Section: Patientsmentioning

confidence: 99%

“…Therefore, preoperative diagnosis of malignant neoplasm is essential. Although a fine-needle aspiration biopsy (FNA) has been applied 12,13 and reported to show a relatively high accuracy of 13.7% to 67.5% for the diagnosis of ACC, it remains controversial whether FNA should be performed for salivary neoplasm. 14 Therefore, computed tomography (CT) and/or magnetic resonance (MR) examinations are common procedures for preoperative examination.…”

Section: Introductionmentioning

confidence: 99%

Imaging features of acinic cell carcinoma: three case reports and a review of the literature

et al. 2004

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Objectives. The purpose of this study was to investigate the imaging characteristics of acinic cell carcinoma in three patients and to present a review of the relevant literature. Methods. The tumor site, shape, size, boundary, internal homogeneity and density, and appearance of contrast enhancement were evaluated in three patients with histologically proven acinic cell carcinoma using computed tomography (CT), magnetic resonance (MR), or ultrasonography (US) images. Through a review of the literature, imaging features are summarized. Results. Acinic cell carcinoma frequently occurred in the parotid gland. The shape and size were various. The tumor was well-circumscribed and homogeneous if there was no cyst, hemorrhage, or calcification within the tumor. Most lesions showed low and high signal intensities on T1 and T2-weighted MR images, respectively. The tumor was slightly or peripherally enhanced by the contrast medium. Conclusions. Acinic cell carcinoma has often been described as a well-circumscribed and homogeneous mass. Even if the tumor in the parotid gland shows benign features on imaging, we should consider acinic cell carcinoma as part of the differential diagnosis.

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Cytologic diagnosis of acinic-cell carcinoma of salivary glands

Cited by 75 publications

References 35 publications

Salivary Gland Tumor Fine-Needle Aspiration Cytology

Salivary Gland Tumor Fine-Needle Aspiration Cytology

Diagnosis of a case of papillary-cystic variant of acinic-cell carcinoma on fine needle aspiration cytology: Myriad of cytomorphological features

Imaging features of acinic cell carcinoma: three case reports and a review of the literature

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