Cytologic Diagnosis of Alveolar Soft Part Sarcoma of the Lower Extremity by Fine Needle Aspiration and Correlation with Core Biopsy

Carter, J. Elliot; Evans, Tara N.; Tucker, J. Allan

doi:10.1159/000325553

Cited by 10 publications

(15 citation statements)

References 16 publications

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“…Thin long crystals seen both within and outside the cytoplasm were seen in only one case, having been highlighted well on MGG stain. These crystalline cytoplasmic structures have previously been reported in ASPS on MGG‐ and on Papanicolaou‐stained smears in occasional case reports 5–7 . They were not identified in any of the cases in the series of Wakely et al.…”

Section: Discussionsupporting

confidence: 53%

Cytopathological diagnosis of alveolar soft part sarcoma, a rare soft tissue neoplasm

et al. 2010

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Section: Discussionsupporting

confidence: 53%

Cytopathological diagnosis of alveolar soft part sarcoma, a rare soft tissue neoplasm

et al. 2010

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“…Needle biopsy prior to surgical resection is widely accepted for assessment of lower extremity tumors [1]. However, preoperative imaging tests remain indispensable, because imaging assists to design surgical planning [2].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: The diagnostic value of time-resolved MR angiography with Gadobutrol at 3T for preoperative evaluation of lower extremity tumors: Comparison with computed tomography angiography

Wu¹,

Jin²,

Li³

et al. 2016

European Journal of Radiology Open

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PurposeTo evaluate the diagnostic value of time resolved magnetic resonance angiography with interleaved stochastic trajectory (TWIST) using Gadobutrol for preoperative evaluation of lower extremity tumors.Materials and methodsThis prospective study was approved by the local Institutional Review Board. 50 consecutive patients (31 men, 19 women, age range 18–80 years, average age 42.7 years) with lower extremity tumors underwent TWIST and computed tomography angiography (CTA). Image quality of TWIST and CTA were evaluated by two radiologists according to a 4-point scale. The degree of arterial stenosis caused by tumor was assessed using TWSIT and CTA separately, and the intra-modality agreement was determined using a kappa test. The number of feeding arteries identified by TWIST was compared with that by CTA using Wilcoxon signed rank test. The ability to identify arterio-venous fistulae (AVF) were compared using a chi-square test.ResultsImage quality of TWIST and CTA were rated as 3.88 ± 0.37 and 3.97 ± 0.16, without statistically significant difference (P = 0.135). Intra-modality agreement was excellent for the assessment of arterial stenosis (kappa = 0.806 ± 0.073 for Reader 1, kappa = 0.805 ± 0.073 for Reader 2). Readers identified AVF with TWIST in 27 of 50 cases, and identified AVF with CTA in 14 of 50 (P < 0.001). Mean feeding arteries identified with TWIST was significantly more than that with CTA (2.08 ± 1.72 vs 1.62 ± 1.52, P = 0.02).ConclusionTWIST is a reliable imaging modality for the assessment of lower extremity tumors. TWIST is comparable to CTA for the identification of AVF and feeding arteries.

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“…[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] The largest series before ours was comprised of 3 cases, all of which were diagnosed correctly by using FNA biopsy. 17 The distinctive pseudoalveolar architecture observed in tissue specimens of ASPS largely is absent from cytologic smears.…”

Section: Cancer Cytopathologymentioning

confidence: 99%

“…Others have reported success in identifying such crystals with Giemsa stain 16 and even with P stain. 18,20 Because PAS staining was not attempted on any of these 10 cases, it is possible that cytoplasmic crystals were overlooked. PAS staining also has been used to successfully identify the coarse granules of ASPS on destained P smears.…”

Section: Cancer Cytopathologymentioning

confidence: 99%

Cytopathology of alveolar soft part sarcoma

Wakely

McDermott

Ali

2009

Cancer Cytopathology

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BACKGROUND:Alveolar soft part sarcoma (ASPS) rarely is subjected to cytopathologic evaluation. With the exception of some very small series, the literature is limited to case reports. The objectives of the current study were to evaluate the cytomorphology of 10 ASPS cases on fine‐needle aspiration (FNA) or imprint cytology, review the literature, and highlight potential diagnostic pitfalls.METHODS:The authors searched their files for all lesions that were signed out as ASPS or suspicious for ASPS and searched the surgical pathology files for any cases of ASPS that had corresponding cytology. FNA was performed using the standard technique. Scrape preparations were performed on tissues that were sent fresh for frozen section examination.RESULTS:Ten cases of ASPS were retrieved from 7 patients (male‐to‐female ratio, 4:3; mean age, 22 years). All had subsequent tissue confirmation. Six specimens were from primary lesions, 3 specimens were from metastases, and 1 intraoperative smear was from a previously aspirated primary mass in a newly diagnosed patient. Anatomic sites of involvement included extremities (5 specimens), trunk/pelvis (3 specimens), oral cavity (1 specimen), and lung (1 specimen). Eight specimens were aspirates, and 2 specimens were intraoperative smears. Nine cases were diagnosed correctly as ASPS/consistent with ASPS, and 1 specimen was diagnosed as “tumor, not otherwise specified”. Cytomorphology included variably cellular smears composed of large cells with an enormous amount of finely granular or vacuolated cytoplasm, markedly enlarged nuclei/nucleoli, and bare nuclei. The cytomorphology of some cases revealed a strong similarity to renal cell carcinoma, clear cell type.CONCLUSIONS:The results of the current study indicated that ASPS has cytomorphology that overlaps with several other neoplasms, including renal cell carcinoma. Nonetheless, the morphologic features, when combined with the clinical presentation, radiologic findings, and ancillary testing, may allow for a specific diagnosis. Cancer (Cancer Cytopathol) 2009. © 2009 American Cancer Society.

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Cytologic Diagnosis of Alveolar Soft Part Sarcoma of the Lower Extremity by Fine Needle Aspiration and Correlation with Core Biopsy

Cited by 10 publications

References 16 publications

Cytopathological diagnosis of alveolar soft part sarcoma, a rare soft tissue neoplasm

Cytopathological diagnosis of alveolar soft part sarcoma, a rare soft tissue neoplasm

RETRACTED: The diagnostic value of time-resolved MR angiography with Gadobutrol at 3T for preoperative evaluation of lower extremity tumors: Comparison with computed tomography angiography

Cytopathology of alveolar soft part sarcoma

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