Cytologic Features of Clear Cell Carcinoma of the Female Genital Tract

Jiménez‐Heffernan, José A.; Vicandi, Blanca; González‐Peramato, Pilar; Pérez-Campos, Ana; López‐Ferrer, Pilar; Perna, Cristian; Viguer, José M.

doi:10.1159/000326282

Cited by 10 publications

(7 citation statements)

References 10 publications

(10 reference statements)

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“…[8][9][10][11][12][13] The most distinct cytological features in all these studies were hyaline, globular, eosinophilic, extracellular substance and ÔraspberryÕ body (or Ômirror ball patternÕ), first described by Nishida et al in peritoneal fluid samples. [8][9][10][11][12][13] The most distinct cytological features in all these studies were hyaline, globular, eosinophilic, extracellular substance and ÔraspberryÕ body (or Ômirror ball patternÕ), first described by Nishida et al in peritoneal fluid samples.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10][11][12][13] The most distinct cytological features in all these studies were hyaline, globular, eosinophilic, extracellular substance and ÔraspberryÕ body (or Ômirror ball patternÕ), first described by Nishida et al in peritoneal fluid samples. 12 In our study we found hyaline, globular, eosinophilic, extracellular substance and ÔraspberryÕ bodies in four of nine positive peritoneal fluid specimens, and in 12 of 14 imprint/scrape samples of the tumour mass. 12 In our study we found hyaline, globular, eosinophilic, extracellular substance and ÔraspberryÕ bodies in four of nine positive peritoneal fluid specimens, and in 12 of 14 imprint/scrape samples of the tumour mass.…”

Section: Discussionmentioning

confidence: 99%

“…More often than other ovarian cancer types, it is associated with ovarian and pelvic endometriosis. [9][10][11][12] The aim of this study was to describe the cytomorphology of CCC of the ovary in intraoperative peritoneal fluid, imprint and scraping samples of tumour tissue with the purpose of recognizing cytological features that permit correct intraoperative diagnosis of CCC. 5 Mostly unilateral, it is a cystic tumour with papillary, tubulocystic and solid microscopic histology patterns with clear and ÔhobnailÕ cellular morphology.…”

Section: Introductionmentioning

confidence: 99%

“…In all reported studies the eosinophilic substance is clearly visible only in May-Grü nwald-Giemsa (MGG)-stained samples. [9][10][11][12] The aim of this study was to describe the cytomorphology of CCC of the ovary in intraoperative peritoneal fluid, imprint and scraping samples of tumour tissue with the purpose of recognizing cytological features that permit correct intraoperative diagnosis of CCC. In addition, we wanted to introduce a cytological feature of eosinophilic, intracytoplasmic inclusions in CCC of the ovary not described in other cytological studies.…”

Section: Introductionmentioning

confidence: 99%

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Intraoperative cytology of clear cell carcinoma of the ovary

et al. 2006

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Section: Discussionmentioning

confidence: 99%

“…[8][9][10][11][12][13] The most distinct cytological features in all these studies were hyaline, globular, eosinophilic, extracellular substance and ÔraspberryÕ body (or Ômirror ball patternÕ), first described by Nishida et al in peritoneal fluid samples. 12 In our study we found hyaline, globular, eosinophilic, extracellular substance and ÔraspberryÕ bodies in four of nine positive peritoneal fluid specimens, and in 12 of 14 imprint/scrape samples of the tumour mass. 12 In our study we found hyaline, globular, eosinophilic, extracellular substance and ÔraspberryÕ bodies in four of nine positive peritoneal fluid specimens, and in 12 of 14 imprint/scrape samples of the tumour mass.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intraoperative cytology of clear cell carcinoma of the ovary

et al. 2006

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“…[63] These raspberry bodies could be seen in fluid specimens as well as in fine needle aspiration (FNA) and scrape samples. [64] The tigroid background, a feature described with FNA cytology of these tumors, is not frequently present in fluids. [65] The hepatocyte nuclear factor 1-alfa (HNF1-alpha) stain is helpful in differentiating clear cell carcinoma of the ovary from high-grade serous carcinoma, given that both will show high-grade nuclear features.…”

Section: Introductionmentioning

confidence: 99%

Abdominopelvic washings: A comprehensive review

Rodrı́guez¹,

Khalbuss²,

Austin³

et al. 2013

CytoJournal

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Intraperitoneal spread may occur with gynecological epithelial neoplasms, as well as with non-gynecological malignancies, which may result in serosal involvement with or without concomitant effusion. Therefore, washings in patients with abdominopelvic tumors represent important specimens for cytologic examination. They are primarily utilized for staging ovarian cancers, although their role has decreased in staging of endometrial and cervical carcinoma. Abdominopelvic washings can be positive in a variety of pathologic conditions, including benign conditions, borderline neoplastic tumors, locally invasive tumors, or distant metastases. In a subset of cases, washings can be diagnostically challenging due to the presence of co-existing benign cells (e.g., mesothelial hyperplasia, endosalpingiosis, or endometriosis), lesions in which there is only minimal atypia (e.g., serous borderline tumors) or scant atypical cells, and the rarity of specific tumor types (e.g., mesothelioma). Ancillary studies including immunocytochemistry and fluorescence in situ hybridization may be required in difficult cases to resolve the diagnosis. This article provides a comprehensive and contemporary review of abdominopelvic washings in the evaluation of gynecologic and non-gynecologic tumors, including primary peritoneal and mesothelial entities.

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Clear-cell adenocarcinoma of the female genital tract: Presence of Hyaline stroma and tigroid background in various types of cytologic specimens

et al. 2005

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Hyaline basement membrane-like stromal material and tigroid background are distinctive cytologic features observed in Diff-Quik (DQ)- or Giemsa-stained smears of clear-cell adenocarcinoma (CCA) of the female genital tract. However, it is uncertain how often these features are present in different types of cytologic specimens, and which type of preparation is optimal for this diagnosis. We therefore reviewed the cytologic features of CCA in three types of specimens, including 15 scrape cytology specimens, 7 fine-needle aspiration (FNA) specimens, and 15 peritoneal cytology specimens, with emphasis on the features observed in DQ-stained smears. The cell morphology in scrape cytology specimens and FNA specimens was comparable, whereas in peritoneal cytology specimens, the cytoplasm was better preserved. Most tumor cells had fragile cytoplasm containing variable amounts of fine vacuoles, and round nuclei with distinct or prominent nucleoli. Hyaline stroma was present in 93% of scrape cytology specimens, 71% of FNA specimens, and 80% of peritoneal cytology specimens. Tigroid background was observed in 47% of scrape cytology specimens, 43% of FNA specimens, but in none of the peritoneal cytology specimens. Formation of a tigroid background may be prevented by the abundant fluid content in peritoneal cytology specimens. Hyaline stroma and tigroid background were uncommonly seen in scrape smears from other types of primary ovarian tumors, mainly juvenile granulosa cell tumor and yolk sac tumor. However, the additional presence of papillary structures allows CCA to be readily distinguished from these other tumors. We propose that scrape cytology offers the best approach for the intraoperative cytologic diagnosis of CCA.

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Cytologic Features of Clear Cell Carcinoma of the Female Genital Tract

Cited by 10 publications

References 10 publications

Intraoperative cytology of clear cell carcinoma of the ovary

Intraoperative cytology of clear cell carcinoma of the ovary

Abdominopelvic washings: A comprehensive review

Clear-cell adenocarcinoma of the female genital tract: Presence of Hyaline stroma and tigroid background in various types of cytologic specimens

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