Cytologic Features of NK/T-Cell Lymphoma

Chan, Amy B.W.; Chan, Wing-Yee; Chow, John

doi:10.1159/000326574

Cited by 10 publications

(14 citation statements)

References 28 publications

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“…12,13 Its reason remains unclear, but sclerosis, specific adhesion molecules or vascular structures have been suggested to be associated with clustering tendency. 8,10,14,18 Immunophenotypic profiles are not entirely specific for the disease entities. 5,9 In the present case, the presence of this histological feature was unclear.…”

Section: Discussionmentioning

confidence: 99%

“…5,9 In the present case, the presence of this histological feature was unclear. 14,18 Additionally, ISH study with probe to EBER is helpful in diagnosis of extranodal NK/T cell lymphoma, nasal type. SCC and LCNEC display more cohesive clusters, more hyperchromatic nuclei, and more coarsely granular chromatin than malignant lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…There is morphological overlap among these tumors. 8,10,14,18 Immunophenotypic profiles are not entirely specific for the disease entities. 10 Thus, combination of immunophenotypic studies and molecular biological studies are essential for the recognition and correct diagnosis of Tcell and NK cell lymphomas.…”

Section: Discussionmentioning

confidence: 99%

“…10 Thus, combination of immunophenotypic studies and molecular biological studies are essential for the recognition and correct diagnosis of Tcell and NK cell lymphomas. 14,18 Additionally, ISH study with probe to EBER is helpful in diagnosis of extranodal NK/T cell lymphoma, nasal type. 5,6,9,10,17 The present study is the first detailed report to demonstrate the cytologic features of uterine cervical extranodal NK/T-cell lymphoma, nasal type on conventional Pap smear.…”

Section: Discussionmentioning

confidence: 99%

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Extranodal NK/T‐cell lymphoma, nasal type of the uterine cervix: A case report

Omori

Oishi

Nakazawa

et al. 2016

Diagnostic Cytopathology

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We report a rare case of extranodal NK/T-cell lymphoma, nasal type of the uterine cervix that showed cytologic features mimicking cervical cancer. A 65-year-old woman presented with vaginal bleeding. Gynecological examination revealed a bulky tumor of the cervix. A conventional Papanicolaou-stained cervical smear showed hypercellularity consisting of numerous variably sized cohesive clusters that mimicked epithelial tumors, with a necrotic and inflammatory background. A small number of individually scattered cells were also identified. These scattered cells showed pleomorphic, often cleaved, or horseshoe-shaped nuclei and pale cytoplasm. Biopsy specimens revealed a diffuse growth of atypical cells with an angiocentric pattern. Extensive necrosis and infiltration of inflammatory cells were present. There were numerous mitotic figures. The tumor cells were positive for CD45RO, CD3ε, CD56, granzyme B, TIA-1, CD7, and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization, and negative for cytokeratin, chromogranin A, synaptophysin, CD4, CD5, CD8, CD20, and CD30. Based on these findings, this tumor was diagnosed as extranodal NK/T-cell lymphoma, nasal type of the uterine cervix.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Extranodal NK/T‐cell lymphoma, nasal type of the uterine cervix: A case report

Omori

Oishi

Nakazawa

et al. 2016

Diagnostic Cytopathology

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“…NKTCL is frequently associated with deletions/mutations of the p53 tumor suppression gene and overexpression of mutant p53 protein as well as high levels of multidrug resistance gene expression, both of which confer chemoresistance and may be related to the poor outcomes of these patents. 5,7 The cytomorphology of NKTCL-NT has been previously reported in fine-needle aspiration specimens from lymph nodes, 8,9 soft tissue masses, 10,11 testis 12 and from an intraoral lesion, 13 as well as from nasal brushing specimens, 14 and in a pleural 8 and a peritoneal fluid specimen. 15 However, some of these case reports describe cases where the cytologic specimen was not diagnostic of NKTCL, requiring subsequent surgical resection, 9,10 or the diagnosis had been previously established on a surgical pathology specimen.…”

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confidence: 84%

Adrenal extranodal NK/T‐cell lymphoma diagnosed by fine‐needle aspiration and cerebrospinal fluid cytology and immunophenotyping: A case report

Dunning

Wudhikarn²,

Safo

et al. 2009

Diagnostic Cytopathology

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The cytologic findings of an extranodal NK/T-cell lymphoma (NKTCL) presenting as a large adrenal mass with leptomeningeal involvement diagnosed by CT-guided fine-needle aspiration and cerebrospinal fluid (CSF) cytology are described. The 65-year-old Caucasian patient presented with progressive headache and multiple cranial nerve neuropathies. Magnetic resonance imaging showed leptomeningeal enhancement surrounding the conus medullaris and cauda equine, and a subsequent PET/CT demonstrated a large right adrenal gland mass. Fine-needle aspiration of the adrenal mass showed occasional large pleomorphic cells with prominent nucleoli, moderate amounts of cytoplasm, and rare large cells with sparse cytoplasmic granules admixed with numerous small lymphocytes. Initial flow cytometry from this sample showed no clonal B-cell population. Immunoperoxidase stains performed on the cell block/core specimen showed that the large atypical cells were positive for CD2, CD30, CD43 and CD56, TIA-1, granzyme, and perforin, but for none of the other T-cell markers used (CD3, CD4, CD5, CD8, CD45RO), which stained the abundant background lymphocytes. A CSF specimen showed similar neoplastic cells and flow cytometry showed an NK-cell population with aberrant immunophenotype. The cytologic findings of the neoplastic cells and the extensive panel of immunoperoxidase stains allowed the diagnosis of NKTCL, which was confirmed by the subsequent flow-cytometric immunophenotyping performed on the CSF. This is, to the best of our knowledge, the first case of NKTCL diagnosed by FNA of the adrenal gland and by CSF cytology.

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Aconitum carmichaelii triggers neurotoxicity and Parkinson‐like symptoms through initiation of ROS‐mitochondrial apoptosis and the Nox5/DJ‐1 signaling pathway

Pang

Song

Miao

et al. 2023

BMEMat

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Background Aconitum carmichaelii, the mother root of Aconitum, has a long‐applied history for treating many diseases in China. Increased use of it has prompted significant concerns regarding its extensive cardiotoxicity and neurotoxicity. The molecular mechanisms underlying A. carmichaelii‐induced neurotoxicity are poorly understood. Methods We took advantage of the zebrafish model to investigate the neurotoxic mechanism of A. carmichaelii. In addition to the behavior and neuronal activity testing, gene expression of neuronal oxidative stress, and apoptosis levels were also analyzed. Results In contrast to the excitatory effect of low‐dose A. carmichaelii decoction, hypoactivity of locomotor behavior, and neural activity, especially telencephalon, were detected in the 20 mg/mL group. High doses of A. carmichaelii induced excessive ROS by downregulating DJ‐1 and activating Nox5, and further triggered cell apoptosis through the bax/bcl2a‐caspase‐9 pathway in zebrafish larva. Mitochondrial protection‐related genes PinK1 and Parkin were upregulated to protect against mitochondrial dysfunction during cellular stress. The ROS scavenger‐NAC significantly alleviated neurotoxicity in the 20 mg/mL group. Conclusion The study reveals the potential mechanism of A. carmichaelii‐induced neurotoxicity and provides new insights into a significant risk marker of A. carmichaelii poisoning.

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Cytologic Features of NK/T-Cell Lymphoma

Cited by 10 publications

References 28 publications

Extranodal NK/T‐cell lymphoma, nasal type of the uterine cervix: A case report

Extranodal NK/T‐cell lymphoma, nasal type of the uterine cervix: A case report

Adrenal extranodal NK/T‐cell lymphoma diagnosed by fine‐needle aspiration and cerebrospinal fluid cytology and immunophenotyping: A case report

Aconitum carmichaelii triggers neurotoxicity and Parkinson‐like symptoms through initiation of ROS‐mitochondrial apoptosis and the Nox5/DJ‐1 signaling pathway

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