Cytologic Features of Pleural Effusion in Apocrine Sweat Gland Carcinoma

Otani, Masako; Maeda, Yoko; Miyake, Yoko; Miura, Myota; Kudo, Motoshige; Ebihara, Yoshiro

doi:10.1159/000327190

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…6 Decapitation secretion observed in histological sections can also be seen in aspirates. 7 Sheets of discrete cells with abundant cytoplasm and monomorphic round nuclei causing difficulty in differentiating a benign from malignant apocrine tumor by cytology has been reported. 8 The cytomorphological features of cutaneous apocrine carcinoma on FNAC closely resemble axillary metastasis of signet ring variants of breast carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Apocrine (cutaneous) sweat gland carcinoma of axilla with signet ring cells: A diagnostic dilemma on fine‐needle aspiration cytology

Pai

Kini

Achar

et al. 2008

Diagnostic Cytopathology

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Carcinoma arising in the apocrine sweat glands is rare and there are few reports describing the cytological features of this neoplasm. We describe the cytological features of a histologically confirmed apocrine carcinoma occurring in a 55-year-old man who presented with an ulcerated mass in the right axilla. Fine-needle aspiration cytology revealed features of a signet ring adenocarcinoma. The significance of this infrequently encountered neoplasm lies in its potential for diagnostic confusion with more common lesions containing signet ring cells. In an axillary mass lesion, cytological features along with clinical correlation are essential to distinguish primary apocrine carcinoma from mammary neoplasms with signet ring cells and other metastatic adenocarcinomas.

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Section: Discussionmentioning

confidence: 99%

Apocrine (cutaneous) sweat gland carcinoma of axilla with signet ring cells: A diagnostic dilemma on fine‐needle aspiration cytology

Pai

Kini

Achar

et al. 2008

Diagnostic Cytopathology

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“…Pagetoid spread with tumor cells invading the normal epidermis has been reported in these lesions. 22 CEA, B72.3, EMA, low molecular weight keratins, alpha-1-antitrypsin, lysozyme, Leu-M1, and LN5 are commonly expressed in AC cells. 17 AC cells have shown PAS-positive staining of diastase-resistant granules and mucosubstances in the cytoplasm and in secretions.…”

Section: Discussionmentioning

confidence: 99%

Anal Apocrine Carcinoma

Hall

Florell²,

Sklow³

et al. 2012

The American Journal of Dermatopathology

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Apocrine carcinoma (AC) is an extremely rare skin appendage tumor, which is located at lower dermal and subcutaneous tissue. We report a case of an anal AC arising from an apocrine adenoma in the anal region, which is only the second case reported in this region. A 71-year-old male presented to clinic with soreness in the anal region for 6 weeks. An excisional biopsy was performed. Histologically, the lesion was poorly circumscribed, infiltrative, and was composed of small to medium sized glands extending to the surgical margins. There were centrally dilated large glands with duct-like openings into the mucosal surface. The larger central glands contain periodic acid-Schiff-positive eosinophilic acellular secretions. At the periphery, there were smaller glands with significant cytologic atypia and numerous mitoses. A diagnosis of AC was made making it the second case report of this very rare malignancy in this region. Although ACs usually do not have a fatal outcome, there have been case reports of distant metastases and even death from this disease, making histologic distinction of this malignancy from a benign apocrine adenoma important. Wide local excision is typically the treatment of choice, although Mohs micrographic surgery has also been used with similar success.

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“…Other theory is that they originate from pluripotent stem cells of sweat gland epithelium. 16 Scrape smears are excellent for diagnosis. If the cells are derived from mucin-secreting epithelium, then staining with Alcian blue dye can reveal the deposition of mucin within the cytoplasm.…”

Section: Discussionmentioning

confidence: 99%