Cytologic features of the nested variant of urothelial carcinoma

Cardillo, Marina; Reuter, Victor E.; Lin, Oscar

doi:10.1002/cncr.10955

Cited by 28 publications

(22 citation statements)

References 43 publications

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“…It has been stated that subtle features are not diagnostic themselves—these subtle features include medium sized round/polygonal cells with abundant, dense, slightly granular basophilic cytoplasm and well-defined cell borders, irregular cell counters, increased nuclear/cytoplasmic ratio, coarse chromatin, and occasional prominent nucleoli [15]. …”

Section: Results/literature Reviewmentioning

confidence: 99%

“…Cardillo and associates [15] stated that in view of the fact that nested variant of urothelial carcinoma is a recently described rare variant of urothelial carcinoma there had not been any prior report of cytologic findings in urine specimens from patients with nested variant of urothelial carcinoma. Cardillo and associates [15] reviewed urine specimens from patients with histologically confirmed nested variant of urothelial carcinoma.…”

Section: Results/literature Reviewmentioning

confidence: 99%

“…Cardillo and associates [15] reviewed urine specimens from patients with histologically confirmed nested variant of urothelial carcinoma. They evaluated urine specimens that were obtained concurrently with or up to 1 month prior to the patient's surgical procedure.…”

Section: Results/literature Reviewmentioning

confidence: 99%

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Nested Variant of Urothelial Carcinoma

Venyo

2014

Advances in Urology

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Background. Nested variant of urothelial carcinoma was added to the WHO's classification in 2004. Aims. To review the literature on nested variant of urothelial carcinoma. Results. About 200 cases of the tumour have been reported so far and it has the ensuing morphological features: large numbers of small confluent irregular nests of bland-appearing, closely packed, haphazardly arranged, and poorly defined urothelial cells infiltrating the lamina propria and the muscularis propria. The tumour has a bland histomorphologic appearance, has an aggressive biological behaviour, and has at times been misdiagnosed as a benign lesion which had led to a significant delay in the establishment of the correct diagnosis and contributing to the advanced stage of the disease. Immunohistochemically, the tumour shares some characteristic features with high-risk conventional urothelial carcinomas such as high proliferation index and loss of p27 expression. However, p53, bcl-2, or EGF-r immunoreactivity is not frequently seen. The tumour must be differentiated from a number of proliferative lesions of the urothelium. Conclusions. Correct and early diagnosis of this tumour is essential to provide early curative treatment to avoid diagnosis at an advanced stage. A multicentre trial is required to identify treatment options that would improve the outcome of this tumour.

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Section: Results/literature Reviewmentioning

confidence: 99%

Section: Results/literature Reviewmentioning

confidence: 99%

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Nested Variant of Urothelial Carcinoma

Venyo

2014

Advances in Urology

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“…4 There is increasing awareness of the existence of histologic variants in high-grade urothelial carcinomas, 5 but only few reports of their corresponding urine cytologic features have been documented. [6][7][8] Lymphoepithelioma-like carcinoma (LELC) is a recently recognized variant of high-grade urothelial carcinomas.9-11 LELC histologically resembles lymphoepithelioma of the nasopharynx. It is characterized by syncytial clusters of large undifferentiated cells with pleomorphic nuclei and prominent nucleoli intermixed with lymphoid cells.…”

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confidence: 99%

Cytomorphology of lymphoepithelioma‐like carcinoma of the urinary bladder: Report of two cases

Cai

Parwani

2008

Diagnostic Cytopathology

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Lymphoepithelioma-like carcinoma (LELC) of the urinary bladder is a rare variant of high-grade urothelial carcinoma. Here, we report urine cytologic findings in two cases of this rare entity, the diagnosis of which was confirmed by histopathological examination of the resected tumors. The cytomorphologic features included large tumor cells with high nuclear to cytoplasmic ratios, vesicular chromatin, and prominent nucleoli, presented as single cells or intermixed with inflammatory cells. The differential diagnosis included otherwise typical high-grade urothelial carcinoma, reactive urothelial cells and rarely large cell lymphoma. The rarity of the tumor cells may impose a diagnostic challenge in urine specimen.

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“…In this report, we identified three high-grade variants of urinary bladder featuring nested, plasmacytoid, and lipoid-cell morphology according to cytological, histological, and immunohistochemical examinations. Cardillo et al 6 reported that the cytologic features of nested urothelial carcinoma include medium-sized, round or polygonal cells, with abundant, dense, slightly granular basophilic cytoplasm, and well-defined cell borders. Our case showed similar findings but with slightly acidophilic cytoplasm and unclear cell or cell cluster margins.…”

Section: Discussionmentioning

confidence: 98%

A case of urothelial carcinoma with triple variants featuring nested, plasmacytoid, and lipoid cell morphology

Shimada¹,

Nakamura²,

Konishi³

2009

Diagnostic Cytopathology

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We present very rare variants of urothelial carcinoma featuring nested, plasmacytoid, and lipoid cell morphology in an 80-year-old female who was admitted to our hospital with mictritional pain and bilateral hydronephrosis. Abdominal computed tomography showed diffuse thickening of the urinary bladder, indicating probable invasion into the surrounding adipose tissue. Cytological tests on a urine specimen revealed medium-sized cancer cell clusters with hyperchromatic nuclei and dense cytoplasm, small clusters of dyshesive cells with eccentric or crescent nuclei, and abundant or vacuolated cytoplasm mimicking plasma cells or lipoblasts. Histopathological findings of the bladder tumor revealed that the nested urothelial carcinoma variants were mainly located in the lamina propria, whereas the plasmacytoid and lipoid-cell variants had deeply infiltrated into cells with a myxoid background. Immunohistochemically, the cancer cells were positive for cytokeratin, epithelial membrane antigen, but not for vimentin, S-100, or hematopoietic markers of plasma cells such as CD79alpha and CD38. The patient received no radiosurgical therapies because of the advanced stage of her disease and died a few months after the initial diagnosis. To our knowledge, this is the first cytological and histological examination of urothelial carcinoma consisting of nested, plasmacytoid, and lipoid-cell variants of the urinary bladder.

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Cytologic features of the nested variant of urothelial carcinoma

Cited by 28 publications

References 43 publications

Nested Variant of Urothelial Carcinoma

Nested Variant of Urothelial Carcinoma

Cytomorphology of lymphoepithelioma‐like carcinoma of the urinary bladder: Report of two cases

A case of urothelial carcinoma with triple variants featuring nested, plasmacytoid, and lipoid cell morphology

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