Cytologic Findings of a Pleomorphic Adenoma of the Breast

Kumar, Perikala V.; Sobhani, Seyed Ali; Monabati, Ahmad; Talei, Abdolrasoul; Shirazi, Babak

doi:10.1159/000326456

Cited by 19 publications

(15 citation statements)

References 9 publications

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“…1 The interest in many reports has focused on the histopathology of the tumor and the results of fi ne-needle aspiration. [1][2][3][4][5][6][7][8] Mammographic features were reported without [9][10][11][12] or with [13][14][15][16][17][18][19] images. The tumor is a well-circumscribed, round to ovoid mass, but sometimes shows an irregular shape with many protuberances.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, imaging studies, such as mammography and ultrasonography, might lead to misinterpretation as a carcinoma. [9][10][11][12][13] We recently encountered a case of pleomorphic adenoma of the breast and report here the mammographic and ultrasonographic fi ndings with the pathology of this rare breast tumor. This case report provides some information about the diagnosis of pleomorphic adenoma of the breast.…”

Section: Introductionmentioning

confidence: 99%

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Pleomorphic adenoma of the breast

et al. 2008

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Pleomorphic adenoma is a very rare benign tumor of the breast. Only 70 cases have been reported in the world literature. Recently, we encountered a case of pleomorphic adenoma of the breast and thus present here the mammographic and ultrasonographic findings with the pathology of this rare breast tumor. The patient was a 76-year-old Japanese woman with a right breast mass. The mammography showed a 1.5-cm, lobulated high-density mass with partially ill-defined margins. Ultrasonography revealed an irregularly shaped mass with partially ill defined borders, hypoechoic and heterogeneous internal echoes, and posterior acoustic enhancement. These findings suggested an invasive carcinoma. Awareness of this type of tumor will help in correct diagnosis, in spite of the rarity of this disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pleomorphic adenoma of the breast

et al. 2008

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“…These findings may trigger a malignant diagnosis, especially if only limited sampling is available for review, such as frozen section or fineneedle aspiration (FNA) material. 1,[3][4][5]17,20,[23][24][25] The differential diagnosis of PAB includes aggressive lesions such as metaplastic carcinoma and phyllodes tumor.We report a case of PAB misdiagnosed as mucinous carcinoma on FNA material and discuss the cytologic and histologic findings of this lesion, with special emphasis on its differential diagnosis, and review of the literature. …”

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confidence: 99%

“…The myoepithelial component of PAB may mimic the stromal cells of a fibroadenoma or of a phyllodes tumor. 5,6,18 FNA of a phyllodes tumor produces cellular aspirates with abundant epithelial cells and groups of spindled stromal cells with a variable degree of nuclear atypia. The lack of highly cellular stromal fragments, atypical stromal cells, mitoses, and necrosis in PAB can be of help in the differential diagnosis with phyllodes tumor.…”

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Pleomorphic adenoma of the breast: Case report and review of the literature

Iyengar

Cody

2005

Diagn. Cytopathol.

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Pleomorphic adenoma of the breast (PAB) is a very rare neoplasm. Although quite unique in its morphology, PAB shares some similarities with adenomyoepithelioma and is considered by some authors as a variant of this entity. Cytologic diagnosis of this lesion can be very challenging, especially when limited sampling is available. The differential diagnosis of PAB includes metaplastic carcinoma. On cytologic material, fibroadenoma and phyllodes tumor should also be considered within the differential diagnosis. We report the findings in a case of PAB, initially misdiagnosed as mucinous carcinoma on fine-needle aspiration, and review the literature regarding this entity. Correct identification of this benign mammary neoplasm is important to avoid unnecessarily aggressive treatment.

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Diagnostic reliability of FNAC for salivary gland swellings: A comparative study

Ashraf

Shaikh

Kamal

et al. 2009

Diagnostic Cytopathology

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A prospective study was conducted to see the sensitivity, specificity, and accuracy of fine needle aspiration cytology (FNAC) for 100 salivary gland swellings in comparison with biopsy. These randomized samples were submitted and reported at the department of pathology, Allama Iqbal Medical College, Lahore. The male to female ratio was 1:1.5. Ages of the patients ranged from 8.5 to 58 years with mean age 33.39 +/- 12.37 years. Maximum number of lesions was found in age group between 21 and 40 years. Parotid gland was involved in 68%, submandibular gland in 30%, and minor salivary glands in 2% patients. Sublingual gland was not involved in any of our subjects. There were 14% cases of non-neoplastic lesions and 86% cases of neoplastic lesions on biopsy. Non-neoplastic lesions included 12 cases of inflammations (three cases of granulomatous inflammation and nine cases of nonspecific chronic inflammation) and two cases of inclusion cysts. Among neoplastic lesions, biopsy revealed 68 cases of benign neoplasia and 18 cases of malignant neoplasia. Non-neoplastic lesions did not show any difference in diagnosis by both techniques. FNAC misdiagnosed four malignant and one benign lesion. Sensitivity, specificity, positive predictive value, and negative predictive value of FNAC for benign neoplastic lesions were 98.52, 87.05, 94.36, and 96.55%, respectively, whereas for malignant neoplastic lesions they were 77.77, 98.78, 93.33, and 95.29%, respectively. In conclusion, FNAC is found to be a highly sensitive and specific technique for diagnosis of most of salivary gland swellings, except for malignant neoplastic lesions where its sensitivity is intermediate. We strongly recommend that FNAC should be adopted as an initial investigation for all salivary gland swellings.

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Cytologic Findings of a Pleomorphic Adenoma of the Breast

Cited by 19 publications

References 9 publications

Pleomorphic adenoma of the breast

Pleomorphic adenoma of the breast

Pleomorphic adenoma of the breast: Case report and review of the literature

Diagnostic reliability of FNAC for salivary gland swellings: A comparative study

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