Cytologic identification of erythrophagocytic neoplasms in dogs

Barger, Anne M.; Skowronski, Melissa C.; MacNeill, Amy L.

doi:10.1111/j.1939-165x.2012.00472.x

Cited by 27 publications

(14 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In dogs, hemophagia has been reported to occur in individual cases of mast cell and plasma cell tumors, megakaryocytic leukemia, and hemophagocytic histiocytic sarcoma [ 1 ]. Therefore, cytologic differentiation of benign and malignant forms of HPS can be problematic.…”

Section: Discussionmentioning

confidence: 99%

Lymphoma-associated hemophagocytic syndrome in six dogs

Suwa

Shimoda

2018

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

Hemophagocytic syndrome (HPS) is a clinicopathological entity characterized by histiocytic proliferation, with marked hemophagocytosis in the reticuloendothelial organs. HPS caused by lymphoma is termed lymphoma-associated hemophagocytic syndrome (LAHS), and there are few reports on canine and feline LAHS. The objective of this study was to examine the clinical, diagnostic, and clinicopathologic features of LAHS in six dogs. The diagnostic criteria of LAHS consisted of lymphoma, bicytopenia or pancytopenia in the blood, and increased hemophagocytosis in the reticuloendothelial organs. In one dog, an ocular form of lymphoma was recognized. A splenic form was recognized in two dogs, and a hepatosplenic form was recognized in three dogs. Immunophenotyping revealed T-cell origin in five dogs and B-cell origin in one dog by polymerase chain reaction for antigen receptor rearrangement analysis. Nonspecific esterase stain was performed to differentiate between neoplastic lymphocytes and hemophagocytes. All five dogs with T-cell lymphoma were diagnosed with large granular lymphocyte (LGL) lymphoma. In three cases, palliative therapy with glucocorticoids was conducted, while the other three cases received chemotherapy as well. The survival times for the three dogs with glucocorticoids only were 6, 6, and 10 days and were 30, 54, and 68 days for the three treated with anticancer therapy. The median survival time for the dogs was 20 days. This report indicates that canine LAHS is likely to be caused by LGL lymphoma, and it has an aggressive behavior and poor general prognosis, as seen in humans.

show abstract

Section: Discussionmentioning

confidence: 99%

Lymphoma-associated hemophagocytic syndrome in six dogs

Suwa

Shimoda

2018

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

show abstract

“…The clinical presentation and the cytologic features raised the suspicion for hemangiosarcoma. While erythrophagocytosis has also been reported in canine histiocytic sarcomas, this tumor is rare in the horse and clinical features were not supportive of this diagnosis; this was therefore considered unlikely …”

Section: Case Presentationmentioning

confidence: 99%

What is your diagnosis? Swelling of the left antebrachium and carpus in a horse

Cian

Stewart

Minshall

et al. 2015

Veterinary Clinical Pathol

View full text Add to dashboard Cite

An 8-month-old Thoroughbred colt was presented to Newmarket Equine Hospital with a 6-week history of swelling of the left antebrachium and carpus. On admission, the horse was bright and alert. Temperature, pulse, and respiration rate were normal. The animal exhibited marked left forelimb lameness. There was marked tense distension of the carpal sheath of the extensor carpi radialis with swelling extending proximally beyond the musculotendinous junction. Carpal flexion was reduced to approximately 10°only. Radiographic examination demonstrated periosteal new bone on the dorsodistal radius, bordering the extensor carpi radialis grooves. Ultrasonography revealed extensive disruption of the extensor carpi radialis muscle and displacement of its tendon of insertion. CBC and serum biochemical profile were unremarkable.At tenoscopy under general anesthesia, the extensor carpal radialis tendon sheath was filled with organized hemorrhagic tissue which extended also proximally, infiltrating the muscle. Multiple small incisional biopsies and impression smears were taken from the lesion. The impression smears were stained with Wright-Giemsa ( Figure 1A and B). A B Figure 1. Impression smear from a proliferative lesion on the extensor carpi radialis tendon sheath of a horse. Wright-Giemsa. (A) 950 objective, (B) 9100 objective.

show abstract

“…Erythrophagocytosis has been described in several round cell and mesenchymal neoplasms in dogs, including multiple myeloma, acute megakaryoblastic leukemia, osteosarcoma, hemangiosarcoma, histiocytic sarcoma, and particularly hemophagocytic histiocytic sarcoma . The cytologic and histologic appearance of the spindle cell population, the cellularity of the neoplastic cell population, and the presence of mucin were consistent with characteristic features of myxosarcoma.…”

Section: Discussionmentioning

confidence: 79%