Cytologic Nuclear Grade of Malignant Breast Aspirates as a Predictor of Histologic Grade

Moroz, Krzysztof; Lipscomb, Jane T.; Vial, Lester J.; Dhurandhar, Nina

doi:10.1159/000332796

Cited by 21 publications

(28 citation statements)

References 14 publications

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“…This might be related to subjectivity in assessment of this characteristic as well as limitation of our eye resolution in detection of subtle grades of nuclear chromasia and granularity with the light microscope. 18 In the present study morphology of chromatin we got 40 % (n=18) cases got score of 2, 37.8% (n=17) cases got score 1and 22.2 %( n=10) cases got score 3.Comparsion of univariate and multiple regression analysis was done with the studies done by Das et al and Lingegowda et al (Table: 6) and (Table: 7). 19 .…”

Section: Discussionsupporting

confidence: 55%

Robinson’s cytological grading of breast carcinoma and its correlation with Scarff Bloom Richardson’s histologic grading

Rajan¹,

Pai²

2014

Int Jour of Biomed Res

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Section: Discussionsupporting

confidence: 55%

Robinson’s cytological grading of breast carcinoma and its correlation with Scarff Bloom Richardson’s histologic grading

Rajan¹,

Pai²

2014

Int Jour of Biomed Res

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“…The progression pattern of nuclear morphometric parameters from benign to atypical, Ductal Carcinoma in Situ (DCIS), and further to invasive carcinoma, has been emphasized in various studies on histopathology. [34816222324] Although this study had only 8 ADH cases, 7 out of 8 cases had nuclear size below the cut-off value and could be correctly classified as benign on morphometry. One of the ADH cases had higher nuclear size parameters, which could be due to overriding of nuclear/cytoplasmic contours during tracings, magnifications used, and speed of conducting analysis.…”

Section: Discussionmentioning

confidence: 97%

“…Nuclear morphometry is capable of detecting changes that are too small to be visually perceived and could be used effectively to classify the inconclusive breast FNACs. [3] When combined with cytology impression, morphometry can improve distinction between benign and malignant lesions, especially in areas of “gray zone,” and thus help resolve cases with diagnostic dilemma.…”

Section: Introductionmentioning

confidence: 99%

“…[345678] There are limited reports of computer-aided image analysis in breast FNAC. [3910111213141516] Nuclear morphometric analysis is better performed on cytology smears than histological tissue samples because cells are intact and well-preserved on FNAC smears as compared to histologic sections, in which processing cuts cells at various planes.…”

Section: Introductionmentioning

confidence: 99%

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Study of nuclear morphometry on cytology specimens of benign and malignant breast lesions: A study of 122 cases

Kashyap

Jain

Shukla

et al. 2017

J Cytol

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Background:Breast cancer has emerged as a leading site of cancer among women in India. Fine needle aspiration cytology (FNAC) has been routinely applied in assessment of breast lesions. Cytological evaluation in breast lesions is subjective with a “gray zone” of 6.9–20%. Quantitative evaluation of nuclear size, shape, texture, and density parameters by morphometry can be of diagnostic help in breast tumor.Aims:To apply nuclear morphometry on cytological breast aspirates and assess its role in differentiating between benign and malignant breast lesions with derivation of suitable cut-off values between the two groups.Settings and Designs:The present study was a descriptive cross-sectional hospital-based study of nuclear morphometric parameters of benign and malignant cases.Materials and Methods:The study included 50 benign breast disease (BBD), 8 atypical ductal hyperplasia (ADH), and 64 carcinoma cases. Image analysis was performed on Papanicolaou-stained FNAC slides by Nikon Imaging Software (NIS)–Elements Advanced Research software (Version 4.00). Nuclear morphometric parameters analyzed included 5 nuclear size, 2 shape, 4 texture, and 2 density parameters.Results:Nuclear morphometry could differentiate between benign and malignant aspirates with a gradually increasing nuclear size parameters from BBD to ADH to carcinoma. Cut-off values of 31.93 μm2, 6.325 μm, 5.865 μm, 7.855 μm, and 21.55 μm for mean nuclear area, equivalent diameter, minimum feret, maximum ferret, and perimeter, respectively, were derived between benign and malignant cases, which could correctly classify 7 out of 8 ADH cases.Conclusion:Nuclear morphometry is a highly objective tool that could be used to supplement FNAC in differentiating benign from malignant lesions, with an important role in cases with diagnostic dilemma.

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“…Apesar de ser método útil no diagnósti-co de carcinoma de mama, existem, ainda, poucos dados a respeito da acurácia da PAAF em estabelecer fatores prognósticos, tais como: o grau histológico e nuclear, o índice mitótico, receptores hormonais, genes de supressão tumoral/ oncogene e o conteúdo de DNA 7 . Alguns estudos têm mostrado que a graduação citológica nos esfregaços de carcinoma de mama correlaciona-se bem com a graduação histológica, sendo altamente reprodutível 7,[8][9][10][11][12][13][14][15][16] . Contudo, a graduação citológica de PAAF de mama não é rotineiramente utilizada 17 .…”

Section: Introductionunclassified

Sistemas de graduação para carcinoma de mama: estudo comparativo da concordância cito-histológica

Dantas¹,

Santos²,

Filho³

2003

Rev. Bras. Ginecol. Obstet.

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A graduação histológica, a infiltração estromal linfoplasmocitária, a invasão vascular, linfática e sanguínea e a infiltração perineural são alguns dos aspectos morfológicos descritos como de importância prognóstica. Dentre estes, o grau histológico tem sido demonstrado como excelente indicador prognóstico [2][3][4] . A avaliação dos parâmetros morfológicos de significado prognóstico tem sido realizada em espécimes de biópsia incisional ou de exérese de nódulos palpáveis. Os meios diagnósticos vêm-se

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Cytologic Nuclear Grade of Malignant Breast Aspirates as a Predictor of Histologic Grade

Cited by 21 publications

References 14 publications

Robinson’s cytological grading of breast carcinoma and its correlation with Scarff Bloom Richardson’s histologic grading

Robinson’s cytological grading of breast carcinoma and its correlation with Scarff Bloom Richardson’s histologic grading

Study of nuclear morphometry on cytology specimens of benign and malignant breast lesions: A study of 122 cases

Sistemas de graduação para carcinoma de mama: estudo comparativo da concordância cito-histológica

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