Cytologic scoring of endometrioid adenocarcinoma of the endometrium

Abstract

We describe two sisters with a mild‐onset variant of Canavan's disease who presented at age 50 and 19 months with developmental delay but without macrocephaly, hypotonia, spasticity, or seizures. Remarkably, both patients had age‐appropriate head control, gross motor development, and muscle tone. There were very mild deficits in fine motor skills, coordination, and gait. Both sisters had a history of strabismus, but otherwise vision was normal. The older child showed evidence of mild cognitive and social impairment, whereas language and behavior were normal for age in the infant. Both patients were found to be compound heterozygotes for C914A (A305E) and G212A (R71H) mutations in ASPA. Like all other known ASPA mutations, this previously unknown G212A mutation appears to have low absolute enzyme activity. Nevertheless, it is associated in these patients with an extremely benign phenotype that is highly atypical of Canavan's disease. Biochemical and clinical data were evaluated using a generalized linear mixed model generated from 25 other subjects with Canavan's disease. There were statistically significant differences in brain chemistry and clinical evaluations, supporting a distinct variant of Canavan's disease. Future studies of ASPA enzyme structure and gene regulation in these subjects could lead to a better understanding of Canavan's pathophysiology and improvements in ASPA gene therapy Ann Neurol 2006;59:428–431

The Role of Liquid-Based Preparation in the Evaluation of Endometrial Cytology

“…The main advantages of this procedure are the reduction in confounding factors, the distribution of cells on a thin layer and the possibility to obtain more slides from the same sample. The two LBP technologies currently in use include ThinPrep (Hologic Inc., Bedford, Mass., USA) and SurePath (BD Diagnostics, Burlington, N.C., USA) and several groups have reported their experience either by using ThinPrep [10,11,14,15] or SurePath [8,9,12,13] methods. There are subtle differences between ThinPrep and SurePath preparations which reflect different sampling devices, collection media and processing techniques [20,21,22,23].…”

“…In fact, the LBP method enables storage of a variable amount of cells. Recently, several studies have described the cellular assessment of endometrial lesions by using cytoarchitectural criteria on LBPs [8,9,10,11,12,13,14,15]. The above described advantages of LBPs versus conventional slides suggest the replacement of conventional slides with LBPs in the routine cytologic evaluation of endometrial cell samples.…”

Evaluation of Endometrial Cytology: Cytohistological Correlations in 1,441 Cancer Patients

“…This method is less invasive than histological biopsy, but its precision for detecting endometrial cancer is still unclear. Most previous studies of endometrial cytology reported its sensitivity and specificity in patients with various backgrounds, from asymptomatic cases to high-risk groups for uterine cancer [4,5]. Consequently, insufficient numbers of uterine cancer cases were reported for stringent analyses of the effectiveness of cytodiagnostics.…”

Advancements in the Use of Blood Tests for Cancer Screening in Women at High Risk for Endometrial and Breast Cancer

“…The authors found that the best cutoff value for distinguishing G1 from the other grades was a score of 17, which had a sensitivity of 83 and a specificity of 81%. The best cutoff value for distinguishing G3 from the other grades was a score of 20, with a sensitivity of 100% and a specificity of 83% [35]. Hysteroscopy future science group Advancements in the use of blood tests for cancer screening Review with selective sampling is a diagnostic method that is replacing the traditional method of dilation and cutterage [33].…”