Cytologic smears improve accuracy of frozen sections of ovarian tumors in the community practice settings

Cimic, Adela; Mironova, Maria; Khoury‐Collado, Fady; Salih, Ziyan

doi:10.4103/cytojournal.cytojournal_20_18

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…We recommend increasing the number of sections examined in IFS when diagnosing multicystic tumors, in order to avoid and lower the rate of discordant IFS and FPP. Cimic et al have also recommended using cytology to improve the accuracy of IFS (34). The presence of ascites by sonography reduced the risk of discordant IFS and FPP diagnoses of malignant ovarian tumors in this study.…”

Section: Discussionmentioning

confidence: 66%

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Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors

et al. 2021

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AimTo retrospectively investigate the pre-operative clinical factors and ultrasonographic features that influence the accuracy of the intraoperative frozen section (IFS) of ovarian tumors.Patients and methodsWomen with ovarian tumors that underwent IFS in one tertiary medical center were recruited from January 2010 to December 2018. Demographic and clinical data of these women were retrieved from medical records in the hospital’s centralized database.ResultsA total of 903 ovarian tumors were enrolled, including 237 (26.2%) benign, 150 (16.6%) borderline tumor, and 516 (57.2%) malignant. The overall accuracy of IFS among all specimens was 89.9%. The sensitivities of IFS in diagnosing borderline tumors (82.0%) and malignant tumors (88.2%) were lower than in diagnosing benign tumors (98.7%, p <0.001, Z-test). The specificity of diagnosing malignant tumors (99.7%) was significantly higher than that of diagnosing benign tumors (94.7%, p <0.001, Z-test). The group with discordant IFS and final paraffin pathology (FPP) had younger age (47.2 ± 14.0 vs. 51.5 ± 11.8 years, p = 0.013, Mann–Whitney U test), and higher percentage of early-stage disease (85.2% vs. 65.1%, p = 0.001, chi-square test) and mucinous (39.3% vs. 3.3%) and endometrioid histologic types (34.4% vs. 20.2%) than the concordant group (all by chi-square test). Menopause (OR 0.34, 95% CI 0.15–0.76, p = 0.009), multicystic tumor in ultrasound (OR 2.14, 95% CI 1.14–4.01, p = 0.018), and ascites existence (OR 0.33, 95% CI 0.14–0.82, p = 0.016) were factors related to the discordant IFS by multivariate analysis.ConclusionsIFS has good accuracy in the diagnosis of ovarian tumors. We recommend more frozen tissue sampling for sonographic multicystic tumors in premenopausal women to improve the accuracy of IFS.

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Section: Discussionmentioning

confidence: 66%

“…Cimic et al. have also recommended using cytology to improve the accuracy of IFS ( 34 ). The presence of ascites by sonography reduced the risk of discordant IFS and FPP diagnoses of malignant ovarian tumors in this study.…”

Section: Discussionmentioning

confidence: 99%

Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors

et al. 2021

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“…The use of touch preps and smears can be valuable in frozen section and intraoperative assessment, reducing deferral and discrepancy rates [26]. In some instances, this approach can replace frozen section [27] although this may be dependent on the experience of the pathologist with tissue examination versus cytology.…”

Section: Touch Preparationsmentioning

confidence: 99%

Quality Assurance in Frozen Section

Borczuk

2021

Frozen Section Pathology

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“…11 Cytological evaluation is also superior to frozen sections in the diagnosis of select types of ovarian neoplasms, but in general frozen section diagnosis is reported to be more accurate and sensitive than that of cytological smears alone, and the latter should play mostly a very useful complementary role. 12 To keep this is mind, an attempt was made to evaluate the diagnostic utility of imprint cytology and assess the accuracy of imprint cytology with histopathological diagnosis obtained from ovarian neoplasm.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic utility of imprint cytology of ovarian neoplasm: A cyto-histological comparison

Ivan¹,

Chacko²,

Thomas³

2020

ACHR

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Background: Intra-operative cytology (IOC) is a method of intra-operative pathological evaluation of cytology smears. The most important indication for IOC is to establish or confirm diagnosis rapidly. Other advantages of IOC are its simple, inexpensive, excellent preservation of cellular details, with no loss of tissues as occurs with cryostat sections and adequacy of surgical margins. Frozen sections are well established method for providing rapid and accurate intra-operative diagnosis. Objective: To evaluate the diagnostic utility of imprint cytology and assess the accuracy of imprint cytology with histopathological diagnosis obtained from ovarian neoplasm. Materials and Methods: Imprint smears were prepared immediately from all the ovariotomy specimens. The specimens were sent for histopathology along with prepared smears to categorize as benign, borderline and malignant. Sensitivity, specificity and accuracy were assessed. Results : Among the 99 specimens studied, 80 were benign, 9 borderline and 10 malignancy according to histopathology. We found that sensitivity, specificity, for benign lesions were 100%, 42.1% and for malignant lesions were 80%, 91.9% respectively. The overall accuracy was 89%. Conclusion : Imprint smear of ovarian neoplasm gives a rapid diagnosis with 89% accuracy against histopathology with added advantages. Imprint cytology is an adjunct to frozen section for providing an intra-operative diagnosis; however, in resource poor settings, it can be used as a stand-alone method for aiding intra-operative decision making.

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Cytologic smears improve accuracy of frozen sections of ovarian tumors in the community practice settings

Cited by 4 publications

References 11 publications

Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors

Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors

Quality Assurance in Frozen Section

Diagnostic utility of imprint cytology of ovarian neoplasm: A cyto-histological comparison

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