Cytologic Studies of Sputum and Bronchial Secretions in Primary Carcinoma of the Lung

Farber, Seymour M.; Benioff, Mortimer A.; Frost, John K.; M, Rosenthal; Tobias, Gerd

doi:10.1378/chest.14.5.633

Cited by 34 publications

(7 citation statements)

References 18 publications

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“…This is in keeping with the experience of others (Umiker, 1961;Attar, Naib and Cowley, 1961 ;Hattori, Matsuda, Sugiyama and Matsuda, 1964 The frequency with which primary lung cancer should be diagnosed without radiological evidence is a matter which is unlikely ever to be satisfactorily determined, since all cancers are radiologically invisible in the first instance. Simon (1966) considers that tumours measuring less than 1-3 cm in diameter are unlikely to be detected, and Spratt, Ter-Pogossian and Long (1963) (Woolner, Andersen and Bernatz, 1960;Lerner, Rosbash, Frank and Fleischner, 1961 ;Russell et al, 1963;Melamed, Koss, and Cliffton, 1963 (Farber et al, 1948 ; Kuesko and Portele, 1949 ;Philps, 1954;Meyer and Umiker, 1961;Hinson and Kuper, 1963;Russell et al, 1963;Melamed and Cahan, 1968). Those with the highest positivity rates have tended to be from small numbers of patients.…”

Section: Radiological Appearancesmentioning

confidence: 99%

The diagnosis of primary lung cancer with special reference to sputum cytology

Oswald¹,

Hinson²,

Canti³

et al. 1971

Thorax

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Of 2,545 in-patients with primary lung cancer, pathological proof of the diagnosis was obtained by sputum cytology in 48%, by bronchoscopy in 32%, by biopsy from miscellaneous sites in 12%, and at thoracotomy or necropsy only in 19%. The diagnosis was made solely on clinical and radiological evidence in 8%.One or more satisfactory specimens of sputum from 2,035 patients gave a positivity rate of 59%. When three specimens of sputum were tested the positivity rate was 69% and when four or more were tested, 85%. The maximum false positivity rate was 0-7%. Agreement between the types of malignant cells found in the sputum and in resected or necropsy specimens occurred in 84%. The pathological diagnosis was based solely on sputum cytology in 40% of the patients in whom malignant cells were found in the sputum.The total work of the sputum laboratories was analysed for one year (1967); sputum was examined from 1,598 patients, of whom 266 (17%) had positive results.Of 1,518 patients who had a bronchoscopy, the positivity rate was 53%, and of 524 patients with biopsies from miscellaneous sites the rate was 64%.Sputum cytology, as practised at present, is a very valuable method of diagnosis, but its demands on time and expertise make it unsuitable for general application outside large medical centres. Bartholomew's Hospital and 29 from Brompton Hospital could not be traced.Notes from a total of 2,545 patients were available for study, 913 from St. Bartholomew's and 1,632 from Brompton. There were 2,176 males and 369 (14%) females. One or more specimens of sputum were submitted for cytological investigation from 2,035 (80%) of the patients, bronchoscopy was performed in 1,518 (60%), and biopsies were taken from other sites in 524 (21%). Lung resection was performed in 1,002 (39%) and a further 199 (8%) (1-1%)The miscellaneous group included 10 bronchiolo-623 on 9 May 2018 by guest. Protected by copyright.

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Section: Radiological Appearancesmentioning

confidence: 99%

The diagnosis of primary lung cancer with special reference to sputum cytology

Oswald¹,

Hinson²,

Canti³

et al. 1971

Thorax

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“…As noted by Foot (1955) and Farber, Benioff, Frost and Rosenthal and Tobias (1948), squamous cells which originate in foci of metaplasia may be difficult to differentiate from malignant squamous cells. In this series, the one false positive report was the result of atypical squamous metaplasia adjacent to a pulmonary infarct which had complicated severe organizing pneumonia.…”

Section: Discussionmentioning

confidence: 94%

“…Farber, Benioff, Frost, Rosenthal and Tobias (1948) reported that histiocytes may also simulate cancer cells. This paper is a presentation of a study of benign atypical cells which simulate malignant cells in sputum or bronchial secretions.…”

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confidence: 99%

False Positive Reports in the Cytologic Diagnosis of Lung Cancer

Umiker¹

1957

Br J Cancer

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“…The procedure has now been extended to other organs and tissues, with increasing accuracy as experience accumulates. Particularly noteworthy are the percentages of correct diagnoses that are being achieved and being constantly improved in bronchogenic carcinoma, by smears of sputum or bronchial secretions (111), in carcinoma of the bladder, by examination of the urinary sediment (112), and in carcinoma of the stomach by cytological study of gastric washings (113).…”

Section: Diagnosis and Treatment Of Cancermentioning

confidence: 99%