Cytological Analysis of Body Fluids and Comparison of Precision in Diagnosis Between Conventional Smear and Cell Block Along with Clinical Correlation

Sridhar, H; S, Ganraj Bhat; Shetty, Balakrishna

doi:10.21276/apalm.2339

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…Even cell block technique appeared to be superior over conventional smear as found by Honnappa et al 12 .…”

Section: Discussionmentioning

confidence: 79%

Role of cell block immunohistochemistry in early diagnosis of lymphoma.

Saha,

Begum,

Baqui Billah

2024

Int. J. Hum. Health Sci.

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Background: Cell block immunohistochemistry (IHC) is an important adjunct for diagnosis of tumour. However, its usefulness in the diagnosis of lymphoma is yet to be established.Objective: We wanted to assess the reliability of cell block IHC in the diagnosis and classification of lymphoma.Methods: This cross-sectional study was carried out among 17 patients with enlarged lymphnode in cytopathology department of Bangabandhu Sheikh Mujib Medical University.Results: IHC could give either positive or negative result in 12 cases, leaving 5 cases as inconclusive, which lead us to remove them from analysis. Cell block IHC diagnosed 9 cases (75%) cases as positive for lymphoma and 3 cases (25%) as negative for lymphoma. The sensitivity, specificity, accuracy, strength, positive predictive value and negative predictive value of cell block IHC were 100% when assessed with final diagnosis based on histopathology and clinical outcome.Conclusion: Cell block IHC could be a useful tool for early diagnosis of lymphoma.International Journal of Human and Health Sciences Vol. 08 No. 02 Apr’24 Page: 203-206

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“…Even cell block technique appeared to be superior over conventional smear as found by Honnappa et al 12 .…”

Section: Discussionmentioning

confidence: 79%

Role of cell block immunohistochemistry in early diagnosis of lymphoma.

Saha,

Begum,

Baqui Billah

2024

Int. J. Hum. Health Sci.

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“…Also, cell block carries advantage of performing immunohistochemistry which helps in the diagnosis and can be used for typing of tumor without invasive tissue biopsy. 4,23,24…”

Section: Discussionmentioning

confidence: 99%

Exfoliative cytology of different body fluids- an important aid to primary diagnosis

Tiwari¹,

Thakur²,

Chandrakar³

et al. 2021

IJPO

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Background: Cytological examination of exfoliated cells in various effusion fluids is very challenging and of paramount importance for early diagnosis and management of various pathological processes. It is of utmost significance in identifying malignant cells and hence throws light on the cause, staging and prognosis of cancer. Aims and Objectives: This study was carried out to know the different trends of various types of effusions for various pathological processes with an emphasis on malignant effusion in a tertiary care centre. Materials and Methods: Retrospective, analytical, observational study done over a period of one year from January 2019 to December 2019. A total of 418 cases including peritoneal and pleural and cerebrospinal fluid and urine were analyzed. Samples were centrifuged for five minutes at 2000 rpm and smears prepared from deposit were stained by Papanicolaou (PAP) and May-Grunwald-Giemsa (MGG) stains. Results: Out of 418, 221 were peritoneal effusions, 172 were pleural, 20 cerebrospinal fluids and 5 urine. Out of 221 cases of peritoneal effusions, 144 were non neoplastic and 61 were malignant effusion. Out of total 172 pleural effusions 139 were non neoplastic and 27 neoplastic. Commonest malignancy in peritoneal and pleural fluid was adenocarcinoma from ovary and lung respectively. Conclusions: Cytological evaluation of various fluids is simple, rapid, inexpensive and less invasive tool with high accuracy and thereby reducing the need for invasive investigations. It is especially helpful in evaluating and staging malignancies thereby guiding the clinician in further management.

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“…We can reduce false negative results and increase diagnostic sensitivity and specificity. Also, cell block carries advantage of performing immunohistochemistry which helps in the diagnosis and can be used for typing of tumor without invasive tissue biopsy [4,17,18] .…”

Section: Discussionmentioning

confidence: 99%

Exfoliative cytology of different body fluids: An important aid to diagnose cancer

Gupta¹,

Rani²,

Bhardwaj³

2021

Int. J. Clin. Diagn. Pathol.

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Background: The cytological examination of exfoliated cells in various effusion fluids is very challenging and is of paramount importance for early diagnosis and management of various pathological processes. It is of utmost significance in identification of malignant cells and hence throws light on the cause, staging and prognosis of various cancers. Materials and Methods: Retrospective, analytical, observational study done over a period of one year from January 2020 to December 2020. A total of 228 cases including peritoneal and pleural and cerebrospinal fluid and urine were analyzed. Samples were centrifuged for five minutes at 2000 rpm and smears prepared from deposit were stained by Papanicolaou (PAP) and May-Grunwald-Giemsa (MGG) stains. Results: Out of 221, 116 were peritoneal effusions, 87 were pleural, 15 cerebrospinal fluids and 3 urine. Out of 116 cases of peritoneal effusions, 60 were non neoplastic and 31 were malignant effusion. Out of total 87pleural effusions 51 were non neoplastic and 19 neoplastic. Commonest malignancy in peritoneal and pleural fluid was adenocarcinoma from ovary and lung respectively. Conclusions: Cytological evaluation of different body fluids is a simple, rapid, inexpensive and less invasive tool with high accuracy and thereby reducing the need for invasive investigations. It is especially helpful in evaluating and staging malignancies thereby guiding the clinician in further management of the patient.

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Cytological Analysis of Body Fluids and Comparison of Precision in Diagnosis Between Conventional Smear and Cell Block Along with Clinical Correlation

Cited by 3 publications

References 3 publications

Role of cell block immunohistochemistry in early diagnosis of lymphoma.

Role of cell block immunohistochemistry in early diagnosis of lymphoma.

Exfoliative cytology of different body fluids- an important aid to primary diagnosis

Exfoliative cytology of different body fluids: An important aid to diagnose cancer

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