Cytological and Tissue Eosinophilia Correlations in Nasal Polyposis

Armengot-Carceller, Miguel; Garín, L; Lamo, Miguel de; Krause, Francisco; Cardá, Carmen

doi:10.2500/ajra.2010.24.3549

Cited by 23 publications

(36 citation statements)

References 15 publications

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“…Allergies have been found to predispose individuals to CRSwNP, as the symptoms of watery rhinorrhea and mucosal swelling were present in the diseases, along with an abundance of eosinophils in the nasal secretions. Some studies have shown that eosinophils are possibly the most important inflammatory cells in the pathogenesis of chronic rhinosinusitis with nasal polyposis [2,15]. Staphylococcus aureus is a common bacterial pathogen that may play an important role in the pathogenesis of CRSwNP via tissue remodeling and eosinophilic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Vitamin D Among Patients with Nasal Polyps in Bolu,Turkey

Apuhan¹,

Buğdaycı²,

Alçelik³

et al. 2012

J Aller Ther

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Background: Nasal polyps are common chronic non-neoplastic growths of the nasal or paranasal sinus mucosa. Vitamin D deficiency, in particular, has been linked to a high rate of both infectious and inflammatory diseases, including those of the upper and lower airways. Aim:In this study, we analyzed the association between plasma 25-hydroxy vitamin D (25[OH]D) levels in patients with nasal polyps. Material and method:Sixty patients (31 male and 29 female), whose ages ranged from 18 to 55 years, were enrolled in this prospective, clinical study.Results: Serum levels of 25 (OH) vitamin D were measured by using a 25 (OH) vitamin D enzyme immune assay kit. There were no statistically significant differences between the control and study groups in plasma 25(OH) D levels, gender, or age (p<0.05). Lung Disorders/Injury both graders and then averaged to yield a mean CT bone erosion score for each patient. The graders were blinded to age, race, gender, and 25-hydroxy vitamin D status of the patients [10,11]. Conclusions

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Section: Discussionmentioning

confidence: 99%

Serum Levels of Vitamin D Among Patients with Nasal Polyps in Bolu,Turkey

Apuhan¹,

Buğdaycı²,

Alçelik³

et al. 2012

J Aller Ther

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“…Patients with CRS who demonstrate greater tissue eosinophilia have been shown to have greater disease severity and worse prognosis and quality of life after surgery . The histopathological degree of tissue eosinophilia has also been demonstrated to be higher in patients with asthma, nasal polyps, and nonsteroidal anti‐inflammatory drug intolerance . However, as noted in one study by Snidvongs et al., the authors found MEC to be a good marker for eosinophilic disease severity regardless of CRS subtype because approximately 19% of patients with eosinophilic disease presented without polyps.…”

Section: Discussionmentioning

confidence: 99%

“…Histological examination of mucosal tissue in patients with CRS typically shows mononuclear cells as well as eosinophils . Tissue eosinophils have previously been implicated as markers of disease severity in patients with CRS, particularly in patients with nasal polyps . Prior immunohistochemical staining of sinonasal tissues for EG2, which is a marker for activated eosinophils, demonstrated all tissue with >5 eosinophils/high‐power field (Eos/HPF) stained positively, suggesting active disease at this histopathologic count .…”

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confidence: 99%

Use of mucosal eosinophil count as a guide in the management of chronic rhinosinusitis

Sharbel

Unsal

et al. 2020

Int Forum Allergy Rhinol

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Background: Chronic rhinosinusitis (CRS) is a local inflammatory process driven by eosinophils. Mucosal eosinophil count (MEC) has previously been demonstrated to be a reliable indicator of disease severity. We aim to evaluate use of MEC in guiding medical management of CRS a er functional endoscopic sinus surgery (FESS). Methods:We retrospectively reviewed patients with CRS who underwent FESS from 2004 to 2017. Tissue MEC per high-power field (HPF) was determined by pathologic examination. MECs were compared by polyp status, postoperative medication requirements, and revision surgery. Patients received normal saline (NS) nasal irrigations with additional treatment as needed for disease control: 1-drug therapy (1-DT) intranasal steroid spray (ISS), 2-drug therapy (2-DT) ISS plus budesonide nasal irrigations (BNI) or leukotriene receptor antagonist (LRA), or 3-drug therapy (3-DT) ISS plus BNI and LRA. Correlations between MEC and 22-item Sino-Nasal Outcome Test (SNOT-22), preoperative computed tomography (CT), and nasal endoscopy scores were evaluated. Results:A total of 156 patients were included. Fi y-seven were managed with 1-DT, 35 with 2-DT, and 62 with 3-DT. Across all patients, mean postoperative 6-month and 1-year SNOT-22 (18.1 ± 17.0, 18.1 ± 20.2, respectively) and nasal endoscopy (3.6 ± 3.8, 3.6 ± 4.1, respectively) scores were significantly lower than preoperative scores (37.4 ± 22.8, 6.5 ± 4, respectively). With increasing MEC, odds of requiring 2-DT (odds ratio [OR] = 1.1, p = 0.0002), 3-DT (OR = 1.12, p < 0.0001), and revision surgery (OR = 1.11, p < 0.0001) were significantly increased. Preoperative endoscopy (ρ = 0.44, p < 0.0001) and CT scores (ρ = 0.51, p < 0.0001) and postoperative 6-month (ρ = 0.55, p < 0.0001) and 1-year (ρ = 0.4, p < 0.0001) endoscopy scores demonstrated good correlation with MEC. Conclusion: MEC correlates with objective clinical disease severity and may guide aggressiveness of management for the individual patient. C 2020 ARS-AAOA, LLC. How to Cite this Article: Sharbel D, Li M, Unsal AA, et al. Use of mucosal eosinophil count as a guide in the management of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2020;10:474-480.C hronic rhinosinusitis (CRS) is an inflammatory condition involving the lining of sinonasal cavities.

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“…Most histological studies of nasal polyp have been performed in Caucasian patients and data from Asian population is still lacking. The majority was found to be eosinophil-predominant, comprising 73-92.5% (Armengot et al 2010; interleukin-8, which is an important chemo-attractant of neutrophil, and size of nasal polyps (Wen et al 2012;Majima 2004), while it showed poor therapeutic efficacy and worse clinical response in eosinophilic NP (Haruna et al 2009;Peric et al 2011). By understanding the histological types of the NP, it would provide us certain prognostic information and allow specific tailored treatments.…”

Section: Discussionmentioning

confidence: 99%

“…Research studies conducted on Caucasian population showed that eosinophil-predominant was the most common feature of NP and ranged between 73-92.5% of their sample size (Armengot et al 2010;Garin et al 2008;Snidvongs et al 2012;Couto et al 2008). However, research studies conducted in India and Asian countries showed that about 48-69% of NP was neutrophil predominant and had lower cases of eosinophil-predominant NP compared to the Caucasian studies (Dafale et al 2012;Hao et al 2006;Ba et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Malaysian Nasal Polyps: Eosinophil or Neutrophil-Predominant

Husain¹

2016

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ABSTRAK Polip hidung jenis eosinofil biasa terjadi dalam populasi ABSTRACTEosinophil-type nasal polyp (NP) is common in Western population. This aim of this study was to determine the histology type of NP among different Malaysian ethnic groups. A total of 122 chronic rhinosinusitis with nasal polyposis (CRSwNP) patients were retrospectively enrolled and demographic data was recorded. The histological slides were retrieved. The number of eosinophils and non-eosinophils were counted and average number of inflammatory cells for each high power field was calculated. Eosinophil-predominant was seen in 32.8% of patients and 67.2% was non-eosinophil-predominant. Phenotypes of NP significantly showed 57

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Cytological and Tissue Eosinophilia Correlations in Nasal Polyposis

Cited by 23 publications

References 15 publications

Serum Levels of Vitamin D Among Patients with Nasal Polyps in Bolu,Turkey

Serum Levels of Vitamin D Among Patients with Nasal Polyps in Bolu,Turkey

Use of mucosal eosinophil count as a guide in the management of chronic rhinosinusitis

Malaysian Nasal Polyps: Eosinophil or Neutrophil-Predominant

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