Cytological characteristics of papillary thyroid carcinoma on LBC specimens, compared with conventional specimens

Suzuki, Ayana; Hirokawa, Mitsuyoshi; Higuchi, Miyoko; Yamao, Naoki; Kuma, Seiji; Nakamura, Hirotoshi; Amino, Nobuyuki; Miyauchi, Akira

doi:10.1002/dc.23191

Cited by 34 publications

(31 citation statements)

References 16 publications

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“…In previous reports, the nuclear and cytoplasmic sizes of follicular cells and well-differentiated thyroid carcinoma cells observed in LBC specimens were smaller than those in conventional specimens because the fixative used for LBC specimens contains formaldehyde [2,3,5]. In our study, the nuclear sizes in LBC specimens were larger than those in conventional specimens in both lymphoma cells and nonneoplastic lymphocytes.…”

Section: Discussionmentioning

confidence: 40%

“…All of the patients were operated on at the Kuma Hospital from January 2013 to November 2016. The diagnosis of MALT-L was based on the following criteria: (1) diffuse proliferation of medium-sized CD20-positive lymphoid cells, (2) packing or lymphoepithelial lesion composed of CD20-positive lymphoid cells and follicular cells, (3) follicular colonization confirmed by structural alterations in the meshwork of CD23-positive follicular dendritic cells, and (4) at least one of restricted light chain (κ/λ ratio > 3 or < 0.33) by flow cytometry, chromosomal abnormality by G-banding, or immunoglobulin heavy chain gene rearrangements [15]. The diagnosis of DLBCL was based on diffuse proliferation of large CD20-positive lymphoid cells.…”

Section: Methodsmentioning

confidence: 99%

“…LBC specimens have been used to identify some diagnostic clues for papillary thyroid carcinoma (PTC), nodular goiter, and follicular neoplasm, such as convoluted nuclei, intercellular spaces, cytoplasmic changes, and membranous ma- terial [2,3]. However, cytological findings from conventional and LBC specimens have shown some differences [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Identification of Cytological Features Distinguishing Mucosa-Associated Lymphoid Tissue Lymphoma from Reactive Lymphoid Proliferation Using Thyroid Liquid-Based Cytology

et al. 2018

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Objective: To identify cytological differences between mucosa-associated lymphoid tissue lymphoma (MALT-L) and nonneoplastic lymphocytes using thyroid liquid-based cytology (LBC). Study Design: We observed LBC and conventional specimens from 35 MALT-L cases, 3 diffuse large B-cell cell lymphoma (DLBCL) cases, and 44 prominent nonneoplastic lymphocytic infiltration cases. Results: In MALT-L cases, the incidence of lymphoglandular bodies in the LBC specimens was lower than that in the conventional specimens (p < 0.001). Moreover, the nuclear sizes in LBC specimens were larger than those in conventional specimens. In 62.9% of the MALT-L and all DLBCL specimens, large nuclei were present in > 10% of the lymphoid cells in LBC specimens. Two cases with prominent nonneoplastic lymphocytic infiltration also exhibited these findings. In LBC specimens, swollen naked nuclei with less punctate chromatin patterns and thin nuclear margins were observed in 92.1% of lymphoma and 20.5% of prominent nonneoplastic lymphocytic infiltration. Elongated nuclei were significantly more apparent in thyroid lymphoma than in prominent nonneoplastic lymphocytic infiltration (p < 0.001), with a significantly higher incidence in LBC specimens than in conventional specimens (p < 0.001). Conclusions: Lymphoglandular bodies are not reliable markers for lymphoma diagnosis using LBC specimens. Large, swollen naked, and elongated nuclei are useful in distinguishing thyroid lymphoma from nonneoplastic lymphocytes in LBC specimens.

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Section: Discussionmentioning

confidence: 40%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Identification of Cytological Features Distinguishing Mucosa-Associated Lymphoid Tissue Lymphoma from Reactive Lymphoid Proliferation Using Thyroid Liquid-Based Cytology

et al. 2018

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“…Therefore, cytopathologist should be cautious in interpreting LBC results if this is the only methodology employed. Several morphological differences were shown and observed among LBCPREP2™, ThinPrep™, and SurePath™ preparations which reflect different sampling devices, collection media, and processing techniques 17, 36, 40. However, all the LBC methods have common and excellent findings such as reduced incidence of air‐drying artifacts, cleaner background, even distribution of cells over a smaller slide area, and increased cellularity.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of liquid‐based cytology with fine needle aspiration specimens for cervical lymphadenopathy

Bandoh

Goto

Akahane

et al. 2016

Diagnostic Cytopathology

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BackgroundCervical lymphadenopathy is a symptom that is frequently seen among outpatients, and it is important to differentiate malignant lesions from reactive lymphoid hyperplasia. Fine needle aspiration (FNA) cytology has been widely used for the diagnosis of cervical lymphadenopathy. However, some limitations of the diagnostic accuracy using conventional smear (CS) cytology have been pointed out. The diagnostic value of liquid‐based cytology (LBC) with FNA specimens has not yet been fully proven.MethodsForty‐two patients with cervical lymphadenopathy who underwent FNA with CS cytology from 2007 to 2011 and 123 patients who underwent FNA with LBC utilizing LBCPREP2™ from 2011 to 2015 were studied. Diagnostic values were compared between the CS and the LBC groups.ResultsOf the total 165 patients representing the combined CS and LBC groups, 81 (49.1%) were diagnosed as benign lymph node and 84 (50.9%) were malignant diseases including 37 (22.4%) of metastatic carcinoma except for thyroid carcinoma, 30 (18.2%) of metastatic thyroid carcinoma, and 17 (10.3%) of malignant lymphoma. The overall statistical values including sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the CS were 75%, 100%, 100%, 78.9%, and 87.1%, respectively, whereas those values for LBC were 91.2%, 100%, 100%, 90.7%, and 95.3%, respectively. The sensitivity of LBC for malignant diseases tended to be higher than that of CS cytology (p = 0.081).ConclusionLBC with FNA specimens from cervical lymphadenopathy is a useful and reliable method for the diagnosis of malignant diseases, especially of metastatic carcinomas, due to its increased sensitivity compared with CS cytology. Diagn. Cytopathol. 2016;44:169–176. © 2016 Wiley Periodicals, Inc.

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“…Recent publications have highlighted certain differences in the cytological features of PTC in LBPs as compared to conventional cytologic preparations [34,35]. In addition, the cytological features of several variants of PTC, such as hobnail, diffuse sclerosing, solid, and cribriform-morular variants should be more fully described and illustrated in the revised TBSRTC.…”

Section: Specific Issues Pertaining To the Different Diagnostic Categmentioning

confidence: 99%

The Bethesda System for Reporting Thyroid Cytopathology: Proposed Modifications and Updates for the Second Edition from an International Panel

Pusztaszeri

Rossi

Auger³

et al. 2016

Acta Cytologica

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116

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The Bethesda System for Reporting Thyroid Cytology (TBSRTC) was proposed in 2007 at the National Cancer Institute Thyroid Fine Needle Aspiration State of the Art and Science Conference held in Bethesda, Maryland. The aim was to address the inconsistent and sometimes confusing reporting terminologies used for thyroid FNA throughout the world. The TBSRTC consists of 6 diagnostic categories, each associated with an implied risk of malignancy that translates directly into a clinical management algorithm. Since the publication of the TBSRTC cytology Atlas in January 2010, considerable experience has been gained regarding its application in cytology practice, clinical impact, and limitations. In conjunction with the International Academy of Cytology (IAC), an international panel composed of sixteen cytopathologists and an endocrinologist with special interest in thyroid cytology, including several co-authors of the 2010 TBSRTC Atlas, was created to: (1) analyze the current worldwide impact of TBSRTC, (2) report on the current state of TBSRTC based upon a review of the published literature, and (3) provide possible recommendations for a future update of TBSRTC. Herein, we summarize the panel's deliberations and key recommendations that our panel hopes will be useful during the preparation of the second edition of TBSRTC.

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Cytological characteristics of papillary thyroid carcinoma on LBC specimens, compared with conventional specimens

Abstract: Convoluted nuclei and perinucleolar halo might become a new indicator of PTC in LBC-S. Contrarily, we should be aware that pale nuclei are rarely observed in LBC-S.

Cited by 34 publications

References 16 publications

Identification of Cytological Features Distinguishing Mucosa-Associated Lymphoid Tissue Lymphoma from Reactive Lymphoid Proliferation Using Thyroid Liquid-Based Cytology

Identification of Cytological Features Distinguishing Mucosa-Associated Lymphoid Tissue Lymphoma from Reactive Lymphoid Proliferation Using Thyroid Liquid-Based Cytology

Diagnostic value of liquid‐based cytology with fine needle aspiration specimens for cervical lymphadenopathy

The Bethesda System for Reporting Thyroid Cytopathology: Proposed Modifications and Updates for the Second Edition from an International Panel

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