Cytological effects of acrylamide on root tip cells of Allium cepa.

Shanker, Rishi; Chauhan, Lalit Kumar Singh; Seth, Prahlad K.

doi:10.1508/cytologia.52.895

Cited by 7 publications

(2 citation statements)

References 11 publications

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“…This decrease might be due to a slower progression of cells from S-phase (DNA synthesis) to M-phase (mitosis) of the cell-cycle. These results were in agreement with Shanker et al (1987) who observed a decrease in MI in the Allium cepa root tips. Shiraishi (1978) also reported a significant mitotic reduction in spermatoganial cells of mice treated with AA.…”

Section: Disclosure Statementsupporting

confidence: 93%

Genotoxic effects of acrylamide in mouse bone marrow cells

Algarni

2018

Caryologia

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Acrylamide (AA) is a human carcinogen generated in carbohydrate-rich foodstuffs upon heating. It has been shown to cause neurotoxic effects in humans, and genotoxic and carcinogenic effects in laboratory animals. The aim of this study was to assess the effects of AA on the frequency of chromosomal aberrations (CA), frequency of micronuclei (MN) and mitotic index (MI). Four groups of four mice, each weighing approximately 20-25 g, were orally administered AA once daily for 30 days with doses of 0, 2, 4, 8, 16, and 32 mg kg -1 body weight of AA. The control group consisted of four animals orally administered deionized water. Bone marrow was collected 24 h after the last treatment following standard protocols. AA significantly increased (p < 0.05) the number of CA and the frequency of micronucleated cells and decreased the MI in exposed groups compared to the negative control. The results obtained in this study further support that AA induces genotoxicity in mouse bone marrow cells.

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Section: Disclosure Statementsupporting

confidence: 93%

Genotoxic effects of acrylamide in mouse bone marrow cells

Algarni

2018

Caryologia

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“…As could be seen from Table 1, the mitotic index (MI) decrease with increasing concentration. Similar results were obtained after treating A. cepa root cells with insecticides, herbicides, pesticides and chemical mutagens (Rao et al, 1987;El-Khodary et al, 1989;Jain and Sarbhoy, 1987;Shanker et al, 1987). A drop of mitotic index indicates that copper wastes interferes in the normal sequences of mitosis.…”

Section: Resultssupporting

confidence: 74%

Cytogenetic Effects of Wastes of Copper Mine on Root Tip Cells of Allium cepa L.

İnceer¹,

Beyazoğlu²,

Ergül³

2000

Pakistan J. of Biological Sciences

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Microbial degradation of acrylamide monomer

1990

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Acrylamide, a neurotoxic monomer with extensive industrial applications was found to be degraded by the microorganisms present in a tropical garden soil. A bacterium capable of degrading acrylamide was isolated from this soil by enrichment. It was found to be aerobic, gram-negative, motile, short rod and identified as Pseudomonas sp. The bacterium degraded high concentrations of acrylamide (4 g/l) to acrylic acid and ammonia which were utilized as sole carbon and nitrogen source for growth. An amidase was involved in the hydrolysis of acrylamide, which could act on other short chain amides like formamide and acetamide but not on acrylamide analogues: methacrylamide and N,N-methylene bisacrylamide. The enzyme was sensitive to catabolite repression by succinate both in presence as well as absence of nitrogen source.

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Cytological effects of acrylamide on root tip cells of Allium cepa.

Cited by 7 publications

References 11 publications

Genotoxic effects of acrylamide in mouse bone marrow cells

Genotoxic effects of acrylamide in mouse bone marrow cells

Cytogenetic Effects of Wastes of Copper Mine on Root Tip Cells of Allium cepa L.

Microbial degradation of acrylamide monomer

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