Cytological features of Castleman disease: a review

Murro, Diana; Agab, Mohamed; Brickman, Arlen; Loew, Jerome; Gattuso, Paolo

doi:10.1016/j.jasc.2015.08.002

Cited by 6 publications

(15 citation statements)

References 12 publications

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“…Castleman's disease, also known as angiofollicular lymph node hyperplasia, is an uncommon lymphoproliferative disorder first described in 1954. [1] Although the histopathological features of Castleman's disease are well established, the diagnosis is challenging on cytology as often the diagnosis is missed or is misdiagnosed as lymphoma. [1] Cytomorphologically, Castleman's disease shows polymorphous population of lymphoid cells with a predominance of small lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

“…[1] Although the histopathological features of Castleman's disease are well established, the diagnosis is challenging on cytology as often the diagnosis is missed or is misdiagnosed as lymphoma. [1] Cytomorphologically, Castleman's disease shows polymorphous population of lymphoid cells with a predominance of small lymphocytes. [1] FDCs are seen admixed with lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

“…It is usually of the hyaline vascular type, or the plasma cell type, or mixed variant. [1] Castleman's disease of hyaline vascular type is known to have nonneoplastic proliferations of spindle cells in compact tangles as well as neoplastic oval-to-spindle cells intermixed with lymphocytes. [12] Reports have shown association of hyaline vascular type Castleman's disease with calcifying fibrous tumor, which is a benign tumor of unknown pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…[1] Castleman's disease of hyaline vascular type is known to have nonneoplastic proliferations of spindle cells in compact tangles as well as neoplastic oval-to-spindle cells intermixed with lymphocytes. [12] Reports have shown association of hyaline vascular type Castleman's disease with calcifying fibrous tumor, which is a benign tumor of unknown pathogenesis. [23456] We report a case of hyaline vascular type Castleman's disease in a 38-year-old male, diagnosed on fine-needle aspiration cytology (FNAC) and subsequently developing calcifying fibrous pseudotumor in the Castleman's disease.…”

Section: Introductionmentioning

confidence: 99%

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Castleman's disease associated with calcifying fibrous tumor: A rare association with review of literature

et al. 2019

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Castleman's disease is a rare disease characterized by unicentric or multicentric enlargement of the lymph node, and it is mostly of the hyaline vascular type. Calcifying fibrous tumor is a neoplasm characterized by large areas of hyalinized collagen with paucicellular areas along with dystrophic calcification and scattered lymphoplasmacytic infiltrates. There are only five case reports to describe an association between these two entities. We report a case of a 38-year-old male with seropositivity for hepatitis B virus presenting with a right-sided cervical swelling. Fine-needle aspiration cytology (FNAC) was done, and a diagnosis of follicular hyperplasia was offered. Biopsy confirmed the diagnosis of Castleman's disease. However, there was associated calcifying fibrous tumor in the lymph node induced by trauma due to FNAC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Castleman's disease associated with calcifying fibrous tumor: A rare association with review of literature

et al. 2019

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“…Castleman disease is a benign lymphoproliferative disorder that may occur in a single (unicentric) or in multiple (multicentric) lymph nodes. The hyaline vascular type is characterized by germinal centers surrounded by concentric rings of mantle zone lymphocytes and a hyalinized vascular proliferation between follicles[ 20 ]. Six cases have been reported from 1999 to 2019 in which CFT was found in association with hyaline vascular type Castleman disease[ 21 - 26 ].…”

Section: Pathogenesismentioning

confidence: 99%

Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update

Turbiville

Zhang

2020

WJG

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Calcifying fibrous tumor (CFT) is a rare mesenchymal lesion that has been documented throughout the gastrointestinal tract. Gastrointestinal CFTs may occur at virtually any age, with a predilection for adults and for females. They occur most commonly in the stomach and the small and large intestines. CFTs are most often found incidentally, cured by local resection, and have a low risk of recurrence. Histology shows three characteristic features: Spindle cell proliferations within a densely hyalinized stroma, scattered calcifications, and lymphoplasmacytic inflammation. CFTs are immunoreactive for CD34, vimentin and factor XIIIa, helping to distinguish them from other benign mesenchymal neoplasms. The differential diagnosis of CFTs includes sclerosing gastrointestinal stromal tumor, leiomyoma, schwannoma, solitary fibrous tumor, inflammatory myofibroblastic tumor, plexiform fibromyxoma, fibromatosis, sclerosing mesenteritis, and reactive nodular fibrous pseudotumor. The pathogenesis of CFTs remains unclear, but some have hypothesized that they may be linked to IgG4-related disease, inflammatory myofibroblastic lesions, hyaline vascular type Castleman disease, sclerosing angiomatoid nodular transformation of the spleen, or trauma.

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“Popcorn cells” in intraoperative touch imprints of nodular lymphocyte‐predominant Hodgkin lymphoma

Aragão

Kılıç²,

Velankar

et al. 2019

Diagnostic Cytopathology

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Cytological features of Castleman disease: a review

Cited by 6 publications

References 12 publications

Castleman's disease associated with calcifying fibrous tumor: A rare association with review of literature

Castleman's disease associated with calcifying fibrous tumor: A rare association with review of literature

Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update

“Popcorn cells” in intraoperative touch imprints of nodular lymphocyte‐predominant Hodgkin lymphoma

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