Cytological features of rosette‐forming glioneuronal tumor of the fourth ventricle

Jiménez‐Heffernan, José A.; Romero, Juan Pedro Vargas; Bárcena, Carmen; Cañizal, José M.

doi:10.1002/dc.24273

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…The characteristic biphasic nature of the tumour, glial and neuronal, can be appreciated on cytology smears. [36][37][38][39] The neuronal component is composed of small neurocytes with uniform round nuclei and occasional small nucleoli, which may form neuropile core rosettes and/or perivascular pseudorosettes (Figure 3C). The glial component often appears pilocityc-like with large "piloid" cells in a faint myxoid background (Figure 3D).…”

Section: Cytological Featuresmentioning

confidence: 99%

Cytopathology of glioneuronal and neuronal tumours with histological correlations

Lacruz,

Álvarez

2023

Cytopathology

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Glioneuronal and neuronal tumours constitute a diverse group of tumours that feature neuronal differentiation. In mixed glioneuronal tumours, a glial component is present in addition to the neuronal component. With a few exceptions (eg diffuse leptomeningeal glioneuronal tumour) they are well‐circumscribed and slow‐growing tumours, which is why their prognosis is intrinsically favourable after gross total resection. Rendering an intraoperative diagnosis of glioneuronal/neuronal tumour is therefore important—neurosurgeons should remove them to prevent the persistence of clinical symptoms and/or recurrence. In this context, cytopathological examination can be especially useful for assessing cellular details when frozen section artefacts render poor‐quality preparations, as is the case for this group of tumours, which are frequently mistaken for infiltrating gliomas (eg diffuse astrocytoma infiltrating grey matter, oligodendroglioma) on frozen section slides. The aim of this article is to review the cytomorphological features of glioneuronal and neuronal tumours according to the 2021 World Health Organization classification of central nervous system tumours, 5th edition. Additionally, since interpretation in intraoperative cytology relies on intuiting tissue patterns from cytology preparations, representative histological figures of all discussed entities have been included. Clues for specific diagnoses and the primary diagnostic problems encountered during intraoperative procedures are also discussed.

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Section: Cytological Featuresmentioning

confidence: 99%

Cytopathology of glioneuronal and neuronal tumours with histological correlations

Lacruz,

Álvarez

2023

Cytopathology

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“…Neurocytic rosettes are not always present in the smears likely due to sampling limitations [40,41]. In other reports, rosettes were evident allowing a more precise diagnosis [42][43][44]. In general, smears are cellular and show glial, fibrillary fragments with capillaries and a dense extracellular mucoid substance.…”

Section: Rosette-forming Glioneuronal Tumor Of the Fourth Ventriclementioning

confidence: 99%

Cytologic Features of Ventricular Tumors of the Central Nervous System: A Review with Emphasis on Diff-Quik Stained Smears

et al. 2021

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Background: Neoplasms from the ventricular system share a common location but have highly variable histogenesis. Many are slowly growing tumors that behave in a benign fashion. They can be classified as primary and secondary tumors. The most common primary tumors are ependymomas, subependymomas, subependymal giant cell astrocytomas, central neurocytomas, choroid plexus tumors, meningiomas, germinomas, pineal parenchymal tumors, papillary tumors of the pineal region, chordoid gliomas, rosette-forming glioneuronal tumors of the fourth ventricle, and craniopharyngiomas. Pilocytic astrocytomas, medulloblastomas, and atypical teratoid/rhabdoid tumors often show secondary involvement of the ventricular system. Summary: Advances in neurosurgery have facilitated access to the ventricular system increasing the number of cases in which such tumors can be biopsied. In this context, cytology has been proven to be an extremely useful diagnostic tool during intraoperative pathologic consultations. Many ventricular tumors are infrequent, and the cytologic information available is limited. In this review, we describe the cytologic features of the uncommon ventricular tumors and report on unusual findings of the more common ones. For the cytologic evaluation of brain tumors, many neuropathologists prefer formalin fixation and hematoxylin and eosin staining. In this review, we highlight the cytologic findings as seen with Diff-Quik, a very popular staining method among cytopathologists. In fact, when pathologists are unfamiliar with cytology, it is common to request the assistance of cytopathologists during the evaluation of intraoperative procedures. Key Message: Ventricular tumors of the central nervous system comprise a group of heterogeneous tumors with very different cytologic features. The cytomorphology of these tumors, including rare entities, is often very characteristic, allowing a precise recognition during intraoperative pathologic consultations. Diff-Quik is a valuable staining method that can be used alone or as a complement to hematoxylin and eosin staining. Diff-Quik allows for clear visualization of the overall architecture, cytoplasmic details, and extracellular material.

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Glioneuronal and Neuronal Tumors

Lacruz,

Jiménez Heffernan

2023

Central Nervous System Tumors

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Cytological features of rosette‐forming glioneuronal tumor of the fourth ventricle

Cited by 5 publications

References 11 publications

Cytopathology of glioneuronal and neuronal tumours with histological correlations

Cytopathology of glioneuronal and neuronal tumours with histological correlations

Cytologic Features of Ventricular Tumors of the Central Nervous System: A Review with Emphasis on Diff-Quik Stained Smears

Glioneuronal and Neuronal Tumors

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