Cytological features of solid variants of papillary thyroid carcinoma: a fine needle aspiration cytology study of 18 cases

Higuchi, Miyoko; Hirokawa, Mitsuyoshi; Suzuki, Ayana; Takada, Nami; Yamao, Naoki; Kuma, Seiji; Miyauchi, Akira

doi:10.1111/cyt.12399

Cited by 18 publications

(29 citation statements)

References 12 publications

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“…Although we found nuclear elongation in most (89%) of our cases, Baloch et al [24] reported nuclei in SVPTC to be more rounded than oval. INIs were found in 67% of the cases in the current study, not very different from the results reported by Higuchi et al [12] (78%) and Ohashi et al [18] (65%). INIs, as expected, were also seen in most (83%) of cPTCs.…”

Section: Discussioncontrasting

confidence: 87%

“…Only 3 studies detailing cytological features of this rare variant have been published [7, 12, 18]; the rest are case reports or lack detailed description [4, 5, 19-22]. We retrospectively evaluated aspiration smears of 9 SVPTC cases we came across over a period of 3 years and compared their various cytomorphological features with those of NIFTP/FVPTC, cPTC, and PDTC.…”

Section: Discussionmentioning

confidence: 99%

“…Higuchi et al [12] in their study of 18 cases described small papillary clusters (besides solid clusters) as a diagnostic clue to SVPTC. The authors found these in 72% of their cases.…”

Section: Discussionmentioning

confidence: 99%

“…Further, a solid fragment was defined as a 3D aggregation of cells without any stromal components, endothelial cell lining, or evidence of microfollicle/papilla formation (Fig. 1d, e) [12]. A trabecula was a multi-layered solid fragment, lined by endothelial cells (Fig.…”

Section: Methodsmentioning

confidence: 99%

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Cytopathology of Solid Variant of Papillary Thyroid Carcinoma: Differential Diagnoses with other Thyroid Tumors

et al. 2018

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Objectives: Solid variant of papillary thyroid carcinoma (SVPTC) is rare, differing from classical PTC (cPTC) in architecture and outcome. We evaluated the cytomorphology of SVPTC cases to assess the feasibility of a preoperative diagnosis. Study Design: SVPTC cases were evaluated for architecture, nuclear features, and Bethesda category and were compared with noninvasive follicular thyroid neoplasm with papillary-like nuclear features/follicular variant of PTC (NIFTP/FVPTC), cPTC, and poorly differentiated thyroid carcinoma (PDTC). Results: Nine SVPTCs, 29 NIFTP/FVPTCs, 12 cPTCs, and 4 PDTCs were included. The predominant architecture in most SVPTCs was solid fragment, which is helpful in differentiating them from NIFTP/FVPTC (p < 0.001) and cPTC (p = 0.006) but not from PDTC. The presence of microfollicles led to misinterpretation as NIFTP/FVPTC/follicular neoplasm in 4 patients. All but 1 SVPTC showed diffuse nuclear features. Intranuclear pseudoinclusions (INIs) were seen in 67% of SVPTCs as compared to 83% of cPTCs, 14% of NIFTP/FVPTCs (p = 0.005), and none of PDTCs. SVPTC cases were commonly (78%) categorized as intermediate/suspicious. Conclusions: The presence of solid fragments and lack of true papillae are helpful in differentiating SVPTC from cPTC. Solid fragments, trabeculae, the extent of nuclear features, and INIs should be looked for in cases with prominent microfollicles for distinguishing SVPTC from NIFTP/FVPTC. None of the features were helpful in differentiating SVPTC from PDTC.

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Section: Discussioncontrasting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

“…Higuchi et al [12] in their study of 18 cases described small papillary clusters (besides solid clusters) as a diagnostic clue to SVPTC. The authors found these in 72% of their cases.…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Cytopathology of Solid Variant of Papillary Thyroid Carcinoma: Differential Diagnoses with other Thyroid Tumors

et al. 2018

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“…The SV is a rare variant of PTC (≤3%) that is still poorly characterized and for which there are conflicting reports about its behavior . It is more common in children and in the Chernobyl nuclear incident survivors (in whom up to 34% of PTCs are SVs).…”

Section: Solid Variantmentioning

confidence: 99%

Update on the cytologic features of papillary thyroid carcinoma variants

Pusztaszeri

Auger

2017

Diagnostic Cytopathology

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Papillary thyroid cancer (PTC), which accounts for 85-90% of all thyroid cancers, is generally an indolent tumor with long term survival rates >95%. A reliable definitive diagnosis of PTC is usually straightforward in fine needle aspirates of conventional PTC whenever the characteristic papillary and/or flat honeycomb sheet-like architecture and the typical nuclear features of chromatin pallor, nuclear enlargement, crowding, grooves and pseudoinclusions are encountered. Conventional PTC, however, has diminished in relative frequency as compared to PTC variants, especially the noninvasive follicular variant of PTC, an indolent tumor which has recently been reclassified as "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP). These PTC variants are characterized by various architecture, cell type and shape, and stromal features, some of which can be recognized cytologically. Awareness of the cytomorphological spectrum and of the characteristic cytological features of these PTC variants is important to avoid diagnostic pitfalls. In this article, we review the different variants of PTC, including their cytomorphologic features, differential diagnosis, and salient molecular features. Diagn. Cytopathol. 2017;45:714-730. © 2017 Wiley Periodicals, Inc.

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Cytologic features of aggressive variants of follicular‐derived thyroid carcinoma

Rossi

Faquin

Pantanowitz

2019

Cancer Cytopathology

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Certain carcinomas of the thyroid gland behave aggressively resulting in increased patient morbidity and poor patient prognosis. The diagnosis of these aggressive thyroid cancer subtypes is sometimes challenging and subject to increased interobserver variability. This review deals with the cytological features of such tumors including aggressive variants of papillary thyroid carcinoma, poorly differentiated thyroid carcinoma, and anaplastic thyroid carcinoma. These malignancies fall into 2 groups based on their cytomorphology: those that exhibit distinct microscopic features (eg, nuclear findings typical of classical papillary thyroid carcinoma or marked anaplasia) and those that present with more subtle cytologic features (eg, nuclear pseudostratification, “soap bubble” nuclei, supranuclear or subnuclear cytoplasmic vacuoles, rosette‐like structures, hobnail cells). We review the literature regarding these aggressive thyroid cancers and highlight important phenotypic characteristics that can be useful for their diagnosis based on fine needle aspiration.

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Cytological features of solid variants of papillary thyroid carcinoma: a fine needle aspiration cytology study of 18 cases

Cited by 18 publications

References 12 publications

Cytopathology of Solid Variant of Papillary Thyroid Carcinoma: Differential Diagnoses with other Thyroid Tumors

Cytopathology of Solid Variant of Papillary Thyroid Carcinoma: Differential Diagnoses with other Thyroid Tumors

Update on the cytologic features of papillary thyroid carcinoma variants

Cytologic features of aggressive variants of follicular‐derived thyroid carcinoma

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