Cytological findings in metastatic carcinoma of the uterus or vagina and the route of metastasis.

Endometrial Aspiration Cytology for Diagnosis of Peritoneal Lesions in Extrauterine Malignancies

“…With respect to the route of the spread of stomach cancer cells to the ovary, leading to the development of Krukenberg's tumor in a narrow sense, it has been suggested that the mechanism of metastasis may be a route via the lymphatic system rather than via diffuse peritoneal carcinomas to the ovary. 15 Regarding the cellular characteristics of positive endometrial cytology in metastatic stomach cancer, the majority of cells were normal endometrial cells and malignant cells appeared as isolated and sporadic small cells, lacking continuity with the surrounding tissue. Most stomach cancer patients with cancerous peritonitis display poorly differentiated adenocarcinoma or signet ring cell carcinoma, and it should be relatively easy to make the diagnosis of gastric cancer dissemination if these characteristic findings are found and if the patient has a past history of stomach cancer.…”