Cytological specimens obtained by endobronchial ultrasound-guided transbronchial needle aspiration: Sample handling and role of rapid on-site evaluation

Yasufuku, Kazuhiro; Feith, Jocelyne Fleury

doi:10.1016/j.annpat.2012.09.212

Cited by 7 publications

(4 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EBUS time varies in different studies basing on the number of passes and the number of lymph nodes that are aspirated. Yasufuku et al [21] examined the sensitivity www.journals.viamedica.pl of EBUS-TBNA in 102 patients. In his study, mean EBUS TBNA time was 14.9 minutes (4-29 minutes).…”

Section: Discussionmentioning

confidence: 99%

The Concurrence of Granulomatous Inflammation in Intrathoracic Lymph Nodes with Regional Metastasis from Primary Lung Cancer in Surgically Resected Specimens

Krvavac

Munzer

Miller

et al. 2018

Advances in Respiratory Medicine

View full text Add to dashboard Cite

Introduction: Granulomatous inflammation has been associated with malignancies such as breast, testicular, renal cell, and lymphoma. The coexistence of granulomatous inflammation in mediastinal/hilar lymph node with primary lung malignancy has been described in case reports. Our goal was to examine the frequency of granulomatous reaction in mediastinal/hilar lymph node in the patients who had undergone surgical resection of lung cancer. Material and methods: We performed a retrospective analysis of 40 patients (1) aged ≥ 18 years and (2) who underwent lobectomy or pneumonectomy from August 1, 2012 to October 31, 2016 at Saint Louis University Hospital and (3) had pathology suggestive of cancer. Results: Of those 40 patients, 3 (7.5%) had granulomatous inflammation in the lymph nodes. None of these 3 individuals had evidence of metastasis in the particular lymph nodes with granulomatous inflammation. Conclusion: Our small cohort revealed that the presence of granulomatous inflammation in a lymph node can be safely taken as an evidence of the absence of metastasis to the lymph node. This finding can obviate the need for further sampling for the particular lymph node with granulomatous inflammation and can decrease the sampling time.

show abstract

Section: Discussionmentioning

confidence: 99%

The Concurrence of Granulomatous Inflammation in Intrathoracic Lymph Nodes with Regional Metastasis from Primary Lung Cancer in Surgically Resected Specimens

Krvavac

Munzer

Miller

et al. 2018

Advances in Respiratory Medicine

View full text Add to dashboard Cite

show abstract

“…Rapid on-site examination (ROSE) of cytology specimens is advocated by multiple experts as being integral to optimal performance of transbronchial needle aspiration (TBNA) [5,6]. Reported advantages include the reduced number of biopsies performed, a lower procedural risk, and an improved cost-effectiveness [7,8], although this finding is not universal [9,10], Furthermore, a high degree of agreement between the on-site and final pathologic evaluation during EBUS-TBNA has been observed [11].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic utility and accuracy of rapid on-site evaluation of bronchoscopic brushings

et al. 2014

View full text Add to dashboard Cite

The aim of the study was to determine the accuracy of rapid on-site examinations, performed on transbronchial brushings of peripheral pulmonary lesions, in determining final bronchoscopic diagnosis. In addition to determining if rapid on-site examination impacts procedural outcomes.A prospective cohort study of consecutive patients with peripheral pulmonary lesions, which had been located by radial endobronchial ultrasound, was undertaken. Bronchoscopy was terminated if rapid on-site examination demonstrated diagnostic malignant material. Non-diagnostic rapid on-site examination resulted in further bronchoscopic sampling, including transbronchial lung biopsy and/or sampling from different locations.128 peripheral pulmonary lesions were located by endobronchial ultrasound in 118 patients. The final bronchoscopic diagnoses included nonsmall cell lung cancer (n=76), carcinoid (n=3), and metastatic malignancy (n=3). Procedure times were significantly shorter for procedures when rapid on-site examinations demonstrated malignancy compared to those where rapid on-site examination was nondiagnostic (19±8 min versus 31±11 min, respectively; p<0.0001). In four procedures, initial negative rapid on-site examination results prompted redirection of sampling from alternate bronchial segments, resulting in positive diagnostic tissue being obtained. Positive and negative predictive value of rapid on-site examination for a malignant bronchoscopic diagnosis was 63 (97%) out of 65, and 43 (68%) out of 63, respectively.Rapid on-site examination of brushing specimens has a very high, positive, predictive value for bronchoscopic diagnosis of cancer and shortens the bronchoscopy procedure times. It has the potential to reduce complications, improve cost-effectiveness, and may improve diagnostic performance via live feedback. @ERSpublications ROSE of bronchial brushings during bronchoscopy for PPL can shorten procedure times and increase diagnostic yield

show abstract

“…Cytological analysis of a fraction of the fresh sample showed extensive infiltration with atypical cells (panels A, B and C; May‐Grünwald‐Giemsa, ×63)…”

Section: Questionmentioning

confidence: 99%

Morphology quiz: Mediastinal adenopathy cytology from endobronchial ultrasound transbronchial aspiration (EBUS‐TBNA)

et al. 2017

View full text Add to dashboard Cite

show abstract

Cytological specimens obtained by endobronchial ultrasound-guided transbronchial needle aspiration: Sample handling and role of rapid on-site evaluation

Cited by 7 publications

References 71 publications

The Concurrence of Granulomatous Inflammation in Intrathoracic Lymph Nodes with Regional Metastasis from Primary Lung Cancer in Surgically Resected Specimens

The Concurrence of Granulomatous Inflammation in Intrathoracic Lymph Nodes with Regional Metastasis from Primary Lung Cancer in Surgically Resected Specimens

Diagnostic utility and accuracy of rapid on-site evaluation of bronchoscopic brushings

Morphology quiz: Mediastinal adenopathy cytology from endobronchial ultrasound transbronchial aspiration (EBUS‐TBNA)

Contact Info

Product

Resources

About