Cytological Study of Breast Lesions with Histopathological Correlation

Abstract

Introduction: Breast disease is the most common and ranks first among malignant tumors affecting females in many parts of the world. Timely and accurate diagnosis of a breast lump is lifesaving. Fine-needle aspiration cytology (FNAC) is a simple, safe, inexpensive method with wide acceptance and used as a first-line diagnostic procedure for diagnosis of breast lesions. Aim: The aim of the study was to diagnose any palpable lump of the breast in females by cytology and correlate with histopathology wherever possible. Setting and Design: This was a retrospective and prospective descriptive study carried out in the pathology department at our institute. Materials and Methods: This study was done for 2 years. FNAC of breast lesions was done, processed routinely, and stained with Papanicolaou stain. Histopathological correlation was done wherever possible on Tru-cut biopsies, excisional biopsies, and surgical specimens received. Statistical Analysis: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated. Results: Among 304 cases, 229 were benign and 75 were malignant on cytology. Out of this, 79 cases underwent histopathological examination, in which 32 were benign and 47 were malignant cases. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the present study were 79.16%, 96.77%, 97.73%, 75%, and 86.08% respectively. Conclusion: The FNAC is an important preliminary diagnostic test in palpable breast lumps and the results show a high degree of correlation with a final histopathological report.

Association of hormone receptors and human epidermal growth factor receptor-2/neu expressions with clinicopathologic factors of breast carcinoma: a cross-sectional study in a tertiary care hospital, Kabul, Afghanistan

“…Triple negative (ER, PR and HER2 negative) BC has different clinical and pathological features due to its relatively poor prognosis, aggressive behavior and lack of targeted therapies [ 19 , 47 ]. In the present study out of 120 patients 23 (19%) were triple negative which is similar to other studies such as Gore with 22% [ 11 ] and Cherry with 23.6% triple negative [ 30 ]. This type of BR has less benefited of target therapy and more aggressive clinical behavior [ 48 , 49 ].…”

“…Several studies have investigated the association between the histopathology of breast tumors, including tumor grade and type, and IHC markers such as ER, PR, and HER2 receptors [ 11 ]. It has been found that there are multiple risk factors for BC that are associated with ER and PR [ 12 ].…”