Cytology and high risk <scp>HPV</scp> testing in cervical cancer screening program: Outcome of 3‐year follow‐up in an academic institute

Yang, Jack; Nolte, Fredrick S.; Chajewski, Olga S.; Lindsey, Kathryn; Houser, Patricia M.; Pellicier, Jalidsa; Wang, Qun; Ehsani, Laleh

doi:10.1002/dc.23843

Cited by 8 publications

(6 citation statements)

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“…Epidemiological studies have demonstrated that HPV, particularly HR-HPV type, is the major causative factor in the development of cervical cancer (9). However, HPV prevalence and type distribution vary depending on geographical region within countries (10).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Genotype Distribution of High-Risk Human Papillomavirus among Chinese Women in Sichuan Province

Chen

et al. 2020

Jpn J Infect Dis

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Section: Discussionmentioning

confidence: 99%

Prevalence and Genotype Distribution of High-Risk Human Papillomavirus among Chinese Women in Sichuan Province

Chen

et al. 2020

Jpn J Infect Dis

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“…Patients diagnosed with cervical cancer often show no obvious signs or symptoms at early stages, which fact can lead to misdiagnosis. The incidence of cervical cancer worldwide varies significantly due to advancements in research and precautionary measures taken by developed countries [5]. Incidence decline can be attributed to regular application of Pap tests, which can reveal CINs and carcinoma in situ before they develop into cervical cancer, and vaccination [6].…”

Section: Introductionmentioning

confidence: 99%

LC/MS-Based Polar Metabolite Profiling Identified Unique Biomarker Signatures for Cervical Cancer and Cervical Intraepithelial Neoplasia Using Global and Targeted Metabolomics

Khan

Nam

Kwon

et al. 2019

Cancers

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Cervical cancer remains one of the most prevalent cancers among females worldwide. Therefore, it is important to discover new biomarkers for early diagnosis of cervical intraepithelial neoplasia (CIN) and cervical cancer, preferably non-invasive ones. In the present study, we aimed to identify unique metabolic signatures for CINs and cervical cancers using global and targeted metabolomic profiling. Plasma samples (69 normal, 55 CIN1, 42 CIN2/3, and 60 cervical cancer) were examined by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-QTOF-MS) coupled with multivariate statistical analysis. Metabolic pathways were analyzed using the integrated web-based tool MetaboAnalyst. A multivariate logistic regression analysis was conducted to evaluate the combined association of metabolites and human papillomavirus (HPV) status with the risk of cervical carcinogenesis. A total of 28 metabolites exhibiting discriminating levels among normal, CIN, and cervical cancer patients (Kruskal–Wallis test p < 0.05) were identified in the global profiling analysis. The pathway analysis showed significantly altered alanine, aspartate, and glutamate metabolic pathways (FDR p-value < 0.05) in both the discovery and validation phases. Seven metabolites (AMP, aspartate, glutamate, hypoxanthine, lactate, proline, and pyroglutamate) were discriminated between CINs and cervical cancer versus normal (area under the curve (AUC) value > 0.8). The levels of these metabolites were significantly high in patients versus normal (p < 0.0001) and were associated with increased risk of developing CIN2/3 and cervical cancer. Additionally, elevated levels of the seven metabolites combined with positive HPV status were correlated with substantial risk of cancer progression. These results demonstrated that metabolomics profiling is capable of distinguishing CINs and cervical cancers from normal and highlighted potential biomarkers for the early detection of cervical carcinogenesis.

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“…Cervical cytologic screening has generally been used to detect cervical cancer and premalignant lesions over the past decade, and early diagnosis and appropriate treatment reduce the risk of cancer-related death. 4 …”

Section: Introductionmentioning

confidence: 99%

Role of <em>Lactobacillus</em> in cervical cancer

Yang¹,

Da²,

Zhang³

et al. 2018

CMAR

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Cervical cancer is a common malignant cancer among women worldwide. Changes in the vaginal microecological environment lead to multiple gynecological diseases, including cervical cancer. Recent research has shown that Lactobacillus may play an important role in the occurrence and development of cervical cancer. This review explores the role of Lactobacillus in cervical cancer. A total of 29 articles were included after identification and screening. The pertinent literature on Lactobacillus in cervical cancer from two perspectives, including clinical studies and experimental studies, was analyzed. An association network for the mechanism by which Lactobacillus induces cervical cancer was constructed. In addition, we provide direction and insight for further research on the role of Lactobacillus in cervical cancer.

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Cytology and high risk HPV testing in cervical cancer screening program: Outcome of 3‐year follow‐up in an academic institute

Abstract: HR-HPV testing plays an important role in cervical cancer screening by identifying HSIL in patients with ASC-US, LSIL, and NILM. Co-testing is an optimal method to identifying the patients with higher risk for developing cervical abnormalities.

Cited by 8 publications

References 50 publications

Prevalence and Genotype Distribution of High-Risk Human Papillomavirus among Chinese Women in Sichuan Province

Prevalence and Genotype Distribution of High-Risk Human Papillomavirus among Chinese Women in Sichuan Province

LC/MS-Based Polar Metabolite Profiling Identified Unique Biomarker Signatures for Cervical Cancer and Cervical Intraepithelial Neoplasia Using Global and Targeted Metabolomics

Role of <em>Lactobacillus</em> in cervical cancer

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