Cytology and Histology of Thyroid Nodules: Exploring Novel Insights in the Molecular Era for Enhanced Patient Management

Cochand-Priollet, Beatrix; Maleki, Zahra

doi:10.3390/curroncol30080562

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…It is highly specific and sensitive for screening of thyroid nodules, with a positive predictive value (PPV) of 97-99%. The PPV can be especially higher if combined with the advancement of molecular testing [42]. Following the identification of the novel entity DHGTC, experts have been diligently seeking indicators of the diagnosis in cytological specimens [43].…”

Section: Cytologymentioning

confidence: 99%

A Comprehensive Review and Insights into the New Entity of Differentiated High-Grade Thyroid Carcinoma

Harahap,

Roren,

Imtiyaz

2024

Current Oncology

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Differentiated high-grade thyroid carcinoma (DHGTC) is a new subset within the spectrum of thyroid malignancies. This review aims to provide a comprehensive overview of DHGTC, focusing on its historical perspective, diagnosis, clinical characteristics, molecular profiles, management, and prognosis. DHGTC demonstrates an intermediate prognosis that falls between well-differentiated thyroid carcinoma and anaplastic thyroid carcinoma. Previously unenumerated, this entity is now recognized for its significant impact. Patients with DHGTC often present at an older age with advanced disease and exhibit aggressive clinical behavior. Molecularly, DHGTC shares similarities with other thyroid malignancies, harboring driver mutations such as BRAFV600E and RAS, along with additional late mutations. The unique behavior and histologic features of DHGTC underscore the necessity of precise classification for prognostication and treatment selection. This highlights the critical importance of accurate diagnosis and recognition by pathologists to enrich future research on this entity further.

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Section: Cytologymentioning

confidence: 99%

A Comprehensive Review and Insights into the New Entity of Differentiated High-Grade Thyroid Carcinoma

Harahap,

Roren,

Imtiyaz

2024

Current Oncology

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Squamous Cells in Thyroid Cytology and Their Clinical Significance: A Multi‐Institutional Study

Pedro,

Harjunpää,

Young

et al. 2024

Diagnostic Cytopathology

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BackgroundSquamous cells are uncommon in thyroid fine needle aspirations (FNAs) presenting diagnostic challenges. We report our multi‐institutional experience.Materials and MethodThe electronic data were searched for thyroid FNAs containing squamous cells at the Johns Hopkins Medicine, New York University Langone Hospital, United States, and Fimlab Laboratories, Finland (2001–2023). The patients' demographics, clinical history, and pathologic diagnosis were recorded.ResultsOne hundred and seven cases (103 patients) were identified 35 males and 68 females (median age 58 years). Forty‐eight cases (44.9%) were malignant, primary carcinomas with squamous features, such as anaplastic thyroid carcinoma (ATC), and metastatic or directly invasive squamous cell carcinomas (SqCC) including oral, oropharyngeal (HPV‐related), esophageal, and laryngeal SqCC. Twenty‐seven cases (25.2%) contained benign squamous cells with cystic background, suggestive of developmental cysts. Nineteen cases (17.8%) contained metaplastic benign squamous cells within an adenomatoid nodule. Seven cases (6.5%) contained atypical squamous cells. Four cases (3.7%) showed squamous cells with bacterial or fungal organisms, suggestive of esophageal fistula/diverticulum, and two cases (1.9%) contained benign squamous cells with unknown source. Thirty‐six cases had surgical follow‐up, 33 (91.7%) were concordant (23 metastatic or directly invasive SqCC, 8 undifferentiated/ATC, and 10 papillary thyroid carcinoma). Ancillary studies were used confirming HPV‐related SqCC, or therapeutic targets (BRAF V600E), with highly variable staining in ATC.ConclusionSquamous cells in thyroid FNAs carry a broad differential diagnosis with variable prognoses. It is crucial to interpret squamous cells in the context of clinical and radiographic findings for optimal patient care.

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Management of a Thyroid Nodule in 2023 (Adults Only)

Maleki,

Cochand-Priollet

2024

Diagnostic Procedures in Patients With Neck Masses

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Cytology and Histology of Thyroid Nodules: Exploring Novel Insights in the Molecular Era for Enhanced Patient Management

Cited by 4 publications

References 16 publications

A Comprehensive Review and Insights into the New Entity of Differentiated High-Grade Thyroid Carcinoma

A Comprehensive Review and Insights into the New Entity of Differentiated High-Grade Thyroid Carcinoma

Squamous Cells in Thyroid Cytology and Their Clinical Significance: A Multi‐Institutional Study

Management of a Thyroid Nodule in 2023 (Adults Only)

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