Cytology of Ascitic Fluid in a Patient with Granulocytic Sarcoma (Extramedullary Myeloid Tumor)

Rowlands, Caroline G.

doi:10.1159/000330982

Cited by 13 publications

(11 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MS can involve many sites of the body, particularly the skin, but also mucous membranes, the orbits, central nervous system, lymph nodes, bone, gonads, other internal organs, and it may even manifest with serous effusions. 3,4 MS involves multiple sites in <10% of cases. The optimal treatment of MS is unclear, but it is generally similar to that of AML, including systemic chemotherapy and possible stem cell transplantation.…”

Section: Introductionmentioning

confidence: 99%

Cytopathology of myeloid sarcoma: a study of 16 cases

Singhal

Pantanowitz

2015

Journal of the American Society of Cytopathology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Cytopathology of myeloid sarcoma: a study of 16 cases

Singhal

Pantanowitz

2015

Journal of the American Society of Cytopathology

View full text Add to dashboard Cite

“…Hicklin and Drevyanko [19] reported the pleural fluid as non-diagnostic with only ‘few atypical leukocytes’; subsequent lymph node and lung biopsies were used to confirm the diagnosis of MS. Rowlands [20] reported myeloid cells of eosinophilic lineage at all stages of differentiation with many immature cells in the ascitic fluid. This provided a clue to the diagnosis of GS.…”

Section: Discussionmentioning

confidence: 99%

Effusion Cytology of Granulocytic Sarcoma in an Unusual Clinical Scenario: A Diagnostic Challenge

Singh

Agarwal²,

Iyer³

et al. 2012

Acta Cytologica

View full text Add to dashboard Cite

Background: Presentation of granulocytic sarcoma (GS) as an effusion is very rare and most cases are misdiagnosed as lymphoma infiltration. Detailed descriptions of cytological features of GS in an effusion have not been published to date. Case Report: We present the case of a 35-year-old male who presented clinically with a mediastinal mass, peripheral lymphadenopathy and pleural/pericardial effusion. His effusion cytology showed an atypical morphology. Immature cells with marked nuclear indentation/convolution, fine nuclear chromatin, conspicuous nucleoli and a moderate amount of cytoplasm were seen, without any granularity. GS was suspected based on the abnormal nuclear contours and fine nuclear chromatin, and was confirmed by lymph node fine needle aspiration and biopsy with immunocytochemistry. Conclusion: Abnormal nuclear contours are a significant marker in effusion cytology and provide an important morphological clue to the diagnosis of a myeloid malignancy in addition to fine nuclear chromatin especially in the absence of cytoplasmic granularity. In this case, these features helped to suspect the diagnosis despite a clinical scenario suggestive of non-Hodgkin’s lymphoma.

show abstract

“…[1][2][3][4][5][6][7][8][9][10][11] The nucleus is characterized by folded or convoluted contours and finely granular chromatin with small nucleoli. 12 Cytoplasmic granules are inconspicuous but highly suggestive. Auer rods, if present, are diagnostic.…”

Section: Discussionmentioning

confidence: 99%

“…Auer rods, if present, are diagnostic. 12 On histology, the pattern of infiltration is diffuse or single file. 1 Lymphoma is the main diagnostic challenge, but the differential diagnosis includes an inflammatory process and Langerhans histiocytosis.…”

Section: Discussionmentioning

confidence: 99%