Cytology of Clear Cell Carcinoma of the Female Genital Tract in Fine Needle Aspirates and Ascites

Atahan, Şafak; Ekinci, Cemil; İçlı, Fikri; Erdoğan, Nural

doi:10.1159/000328588

Cited by 24 publications

(25 citation statements)

References 10 publications

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“…[8][9][10][11][12][13] The most distinct cytological features in all these studies were hyaline, globular, eosinophilic, extracellular substance and ÔraspberryÕ body (or Ômirror ball patternÕ), first described by Nishida et al in peritoneal fluid samples. [8][9][10][11][12][13] The most distinct cytological features in all these studies were hyaline, globular, eosinophilic, extracellular substance and ÔraspberryÕ body (or Ômirror ball patternÕ), first described by Nishida et al in peritoneal fluid samples.…”

Section: Discussionmentioning

confidence: 99%

“…More often than other ovarian cancer types, it is associated with ovarian and pelvic endometriosis. [9][10][11][12] The aim of this study was to describe the cytomorphology of CCC of the ovary in intraoperative peritoneal fluid, imprint and scraping samples of tumour tissue with the purpose of recognizing cytological features that permit correct intraoperative diagnosis of CCC. 5 Mostly unilateral, it is a cystic tumour with papillary, tubulocystic and solid microscopic histology patterns with clear and ÔhobnailÕ cellular morphology.…”

Section: Introductionmentioning

confidence: 99%

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Intraoperative cytology of clear cell carcinoma of the ovary

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intraoperative cytology of clear cell carcinoma of the ovary

et al. 2006

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“…8 This has been observed in ascitic cytology from patients with CCC but also in fine needle aspiration samples. 9 This hyaline material has been identified as basement membrane material and is very characteristic of clear cell carcinoma of the female genital tract. 10 In this cases report, the cytologic features of a case of CCC are evaluated and correlated with histopathology.…”

mentioning

confidence: 99%

Clear Cell Carcinoma of the Ovary Diagnosed in Ascitic Fluid

Vera-Alvarez

García-Prats²,

Marigil-Gómez³

et al. 2007

Acta Cytologica

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“…[1][2][3][4][5][6][7] The distinctive cytologic features of CCA are best seen in Diff-Quik (DQ)-or May-Grünwald-Giemsastained smears. The cytologic characters of CCA have been reported in various types of specimens, including cervicovaginal smears, effusion specimens, fine-needle aspiration (FNA) specimens and scrape cytologic specimens.…”

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confidence: 99%

Clear-cell adenocarcinoma of the female genital tract: Presence of Hyaline stroma and tigroid background in various types of cytologic specimens

et al. 2005

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Hyaline basement membrane-like stromal material and tigroid background are distinctive cytologic features observed in Diff-Quik (DQ)- or Giemsa-stained smears of clear-cell adenocarcinoma (CCA) of the female genital tract. However, it is uncertain how often these features are present in different types of cytologic specimens, and which type of preparation is optimal for this diagnosis. We therefore reviewed the cytologic features of CCA in three types of specimens, including 15 scrape cytology specimens, 7 fine-needle aspiration (FNA) specimens, and 15 peritoneal cytology specimens, with emphasis on the features observed in DQ-stained smears. The cell morphology in scrape cytology specimens and FNA specimens was comparable, whereas in peritoneal cytology specimens, the cytoplasm was better preserved. Most tumor cells had fragile cytoplasm containing variable amounts of fine vacuoles, and round nuclei with distinct or prominent nucleoli. Hyaline stroma was present in 93% of scrape cytology specimens, 71% of FNA specimens, and 80% of peritoneal cytology specimens. Tigroid background was observed in 47% of scrape cytology specimens, 43% of FNA specimens, but in none of the peritoneal cytology specimens. Formation of a tigroid background may be prevented by the abundant fluid content in peritoneal cytology specimens. Hyaline stroma and tigroid background were uncommonly seen in scrape smears from other types of primary ovarian tumors, mainly juvenile granulosa cell tumor and yolk sac tumor. However, the additional presence of papillary structures allows CCA to be readily distinguished from these other tumors. We propose that scrape cytology offers the best approach for the intraoperative cytologic diagnosis of CCA.

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Cytology of Clear Cell Carcinoma of the Female Genital Tract in Fine Needle Aspirates and Ascites

Cited by 24 publications

References 10 publications

Intraoperative cytology of clear cell carcinoma of the ovary

Intraoperative cytology of clear cell carcinoma of the ovary

Clear Cell Carcinoma of the Ovary Diagnosed in Ascitic Fluid

Clear-cell adenocarcinoma of the female genital tract: Presence of Hyaline stroma and tigroid background in various types of cytologic specimens

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