Cytology of salivary duct carcinoma

Chen, Karl T. K.

doi:10.1002/(sici)1097-0339(200002)22:2<132::aid-dc17>3.0.co;2-t

Cited by 15 publications

(8 citation statements)

References 6 publications

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“…LG-SDC is an exceedingly rare neoplasm with approximately 39 cases published in the English literature since 1996 [1,[3][4][5][6][7][8][9][10][11][12][13].…”

Section: Clinical Featuresmentioning

confidence: 99%

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Kuo¹,

Weinreb²,

Perez-Ordonez³

2013

Head and Neck Pathol

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Low-grade salivary duct carcinoma (LG-SDC) is a rare neoplasm characterized by predominant intraductal growth, luminal ductal phenotype, bland microscopic features, and favorable clinical behavior with an appearance reminiscent of florid to atypical ductal hyperplasia to low grade intraductal breast carcinoma. LG-SDC is composed of multiple cysts, cribriform architecture with ''Roman Bridges'', ''pseudocribriform'' proliferations with floppy fenestrations or irregular slits, micropapillae with epithelial tufts, fibrovascular cores, and solid areas. Most of the tumor cells are small to medium sized with pale eosinophilic cytoplasm, and round to oval nuclei, which may contain finely dispersed or dark condensed chromatin. Foci of intermediate to high grade atypia, and invasive carcinoma or micro-invasion have been reported in up to 23 % of cases. The neoplastic cells have a ductal phenotype with coexpression of keratins and S100 protein and are surrounded by a layer of myoepithelial cells in noninvasive cases. The main differential diagnosis of LG-SDC includes cystadenoma, cystadenocarcinoma, sclerosing polycystic adenosis, salivary duct carcinoma in situ/highgrade intraductal carcinoma, and papillary-cystic variant of acinic cell carcinoma. There is no published data supporting the continuous classification of LG-SDC as a variant of cystadenocarcinoma. Given that most LG-SDC are noninvasive neoplasms; the terms ''cribriform cystadenocarcinoma'' and LG-SDC should be replaced by ''low-grade intraductal carcinoma'' (LG-IDC) of salivary gland or ''lowgrade intraductal carcinoma with areas of invasive carcinoma'' in those cases with evidence of invasive carcinoma.

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“…LG-SDC is an exceedingly rare neoplasm with approximately 39 cases published in the English literature since 1996 [1,[3][4][5][6][7][8][9][10][11][12][13].…”

Section: Clinical Featuresmentioning

confidence: 99%

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Kuo¹,

Weinreb²,

Perez-Ordonez³

2013

Head and Neck Pathol

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“…Intraductal carcinoma of the salivary gland was initially defined as an in situ ductal carcinoma with an intact myoepithelial cell layer around all tumor islands [2]. Subsequently, several other such tumors, called low-grade salivary duct carcinomas, have been reported [4][5][6][7][8][9][10][11][12]. Intraductal carcinoma of the salivary gland has been described as a precursor of SDC [5].…”

Section: Discussionmentioning

confidence: 99%

“…Although not recognized as an entity by the 2005 WHO classification, intraductal carcinoma was found to be a rare, indolent malignant neoplasm characterized by an intraductal proliferation of malignant cells, similar to ductal carcinoma in situ of the breast [3]. Subsequent reports of similar tumors [4][5][6][7][8][9][10][11][12] have shown that they affect the major salivary glands more frequently than the minor salivary glands. Owing to the rarity of intraductal carcinoma in the minor salivary glands, appropriate therapy has not been determined.…”

Section: Introductionmentioning

confidence: 99%

An extremely rare salivary gland tumor: intraductal carcinoma of the buccal mucosa

et al. 2015

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Intraductal carcinoma of the salivary gland is a rare, indolent neoplasm characterized by intraductal malignant cell proliferation but lacking invasiveness, in contrast to conventional salivary duct carcinoma, a clinically aggressive neoplasm with invasive characteristics. The tumor affects the major salivary glands much more frequently than the minor salivary glands. This report describes an extremely rare intraductal carcinoma arising from the buccal mucosa in a 61-year-old man who presented with a painless mass in the left buccal mucosa, which he had had for 1 month. A biopsy of the tumor indicated it was most likely an adenocarcinoma, but accurate preoperative diagnosis was difficult. The tumor was completely removed, along with sufficient margins. Histological examination revealed that the lesion was composed of proliferating epithelial cells surrounded by an intact myoepithelial layer, with no evidence of invasion. The final diagnosis was intraductal carcinoma of the salivary gland. No recurrence has been observed for over 3 years. In conclusion, the difficulty in preoperatively diagnosing this rare entity suggests that complete surgical excision with sufficient margins remains the best treatment option.

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“…In 2013, two publications summarized all of the published findings of LGSDC in the English language literature [4,5]. (The literature reviews did not overlap entirely; Wang [5] included two new patients and excluded a number of reports [6][7][8][9][10].) A wide age range is reported , mean 61.4 years) with a female predominance (F:M = 1.5:1) [4].…”

mentioning

confidence: 99%

“…In total, five reported cases of LGSDC demonstrated limited areas of transition to higher cytologic grade including necrosis; [1,2,11,12] this includes an unusual case demonstrating intraductal LGSDC, foci of typical intraductal and invasive high-grade salivary duct carcinoma (HGSDC), plus multiple regional lymph node metastases of high-grade carcinoma [12]. Importantly, all reported patients with LGSDC, to date, including this latter case, are disease-free [1][2][3][4][5][6][7][8][9][10][11][12][13][14].…”

mentioning

confidence: 99%