Cytology of “Significant” Breast Ductal Proliferations

Gangopadhyay, M.; Nijhawan, Raje; Joshi, Kusum; Gupta, Subhash K.

doi:10.1159/000332797

Cited by 11 publications

(11 citation statements)

References 3 publications

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“…Usually the indication for FNAC is to rule out malignancy. [23] In the present study, we observed 4 (1.43%) cases of phyllodes which is similar to reported by Likhar et al [15] in 2013.The number of malignant lesions in the present study was 46 (16.43%) cases which is in concordance with Park and Han [11] , Rochar et al [12] and Dominguer et al [13] . Maximum number of malignant cases were in 41 to 50 years of age group which is similar to the results by Khan et al [24] .…”

Section: Discussionsupporting

confidence: 91%

Cytomorphological Study of Palpable Breast Lumps: Spectrum of Lesions and Diagnostic Utility of FNAC

Ahmad¹,

Mittal²,

Verma³

et al. 2016

AIMDR

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Background: Palpable breast lumps are quite common which can be benign or malignant. Carcinoma breast is the second most common cancer after cervical cancer. Fine needle aspiration cytology (FNAC) is a minimally invasive, rapid, reliable and cost-effective outdoor procedure to provide effective diagnosis and way to further planning of treatment without need for biopsy. The objective of the study is to study the spectrum of various breast lesions on cytomorphology and its histopathological correlation. Methods: This was a two years retrospective study from June 2014 to May 2016 including 280 cases aspirated from palpable breast lumps. Physical examination of breast lumps by palpation was done. Cytological diagnosis was made and histopathological correlation was done, wherever available. Results: On cytomorphological study of 280 breast lump aspirates 32 (11.43%) were inflammatory lesions, 180 (64.29%) benign, 6 (2.14%) atypical/probably benign, 8 (2.86%) suspicious of malignancy, 46 (16.43%) malignant and 8 (2.86%) were unsatisfactory for evaluation, of these 280 cases, 70 (25%) were available for histopathological examination. The most common benign lesion in the present study was fibroadenoma 115 (41.07%) and the most common malignant lesion was ductal carcinoma 43 (15.36%). Conclusion: Fine needle aspiration cytology is a rapid and reliable tool to provide effective diagnosis in palpable breast lumps. It should be used as routine diagnostic procedure to provide the effective health care to the patients with breast lesions.

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Section: Discussionsupporting

confidence: 91%

Cytomorphological Study of Palpable Breast Lumps: Spectrum of Lesions and Diagnostic Utility of FNAC

Ahmad¹,

Mittal²,

Verma³

et al. 2016

AIMDR

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“…Another subject of continuing debate is whether FNA cytology is an effective tool for distinguishing between atypical ductal hyperplasia and higher-grade lesions. Although, in a previous study, 17 we highlighted the usefulness of cytology in this respect, its role has been questioned. 18 These issues being of paramount importance, attention was once focused on the cytoplasmic features of carcinoma.…”

Section: Discussionmentioning

confidence: 86%

Cytoplasmic vacuolation, intracytoplasmic lumina, and DPAS staining in ductal carcinoma of the breast

Nijhawan

Rajwanshi

Gautam

et al. 2003

Diagnostic Cytopathology

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A retrospective study was carried out on 30 cases of histologically proven invasive ductal carcinoma of the breast with a prior fine-needle aspiration (FNA) cytology. On evaluating the May-Grünwald-Giemsa (MGG) FNA smears, cytoplasmic vacuolation was observed in 70% cases. Positivity with periodic acid Schiff-positive, diastase-resistant (DPAS) staining was observed in 90% of cases. The chi(2) value on a McNemar test was 4.16. Thus, DPAS staining was significantly superior to MGG staining for picking up cytoplasmic vacuoles (P < 0.05). In 56.67% cases, DPAS staining showed an improvement in score as compared to MGG smears. This was highly significant (P < 0.001) on Wilcoxon matched-pairs signed-ranks test. Applying the strict criteria of thick-walled cytoplasmic vacuoles with a central darkly stained dot, none of our cases revealed true intracytoplasmic lumina. Larger studies are required to establish a role for DPAS staining in separating borderline, in situ, and invasive breast lesions, and to see if such positvity can be incorporated into the grading systems for breast carcinoma.

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“…[7,10,11,24] Therefore, it is necessary that an accurate diagnosis on cytology be offered. [8,12,13,15,25,26] Of these, we have studied the criteria put forth by Masood et al [10] We have found the six cytological parameters proposed by Masood et al, [4] which are useful for cytological scoring of breast lesions. We found that to increase the accuracy of various groups, the scoring index be slightly modified; NPBD, which had score of 6-10, was modified to score of 6-8 with shift of score 9 and 10 to PBD without atypia, i.e., score 11-14 is modified to score 9-14.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of scoring system in cytological diagnosis and management of breast lesion with review of literature

2011

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Cytology of “Significant” Breast Ductal Proliferations

Cited by 11 publications

References 3 publications

Cytomorphological Study of Palpable Breast Lumps: Spectrum of Lesions and Diagnostic Utility of FNAC

Cytomorphological Study of Palpable Breast Lumps: Spectrum of Lesions and Diagnostic Utility of FNAC

Cytoplasmic vacuolation, intracytoplasmic lumina, and DPAS staining in ductal carcinoma of the breast

Evaluation of scoring system in cytological diagnosis and management of breast lesion with review of literature

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