Cytolytic and membrane-perturbing properties of lysophosphatidylcholine

Weltzien, Hans Ulrich

doi:10.1016/0304-4157(79)90004-2

Cited by 572 publications

(262 citation statements)

References 124 publications

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“…Recently GPC has been hypothesized as a regulator of membrane functionality [6]: the level of lysolecithin in membranes [23] is modulated by c~oplasmic GPC acting as an inhibitor of lysolecithinase. The prerequisite for this hypothesis is that the concentration of GPC varies according to different physiological states.…”

Section: Discussionmentioning

confidence: 99%

Modulation of glycerophosphorylcholine and glycerophosphorylethanolamine in rice shoots by the environment oxygen level

Menegus¹,

Fronza²

1985

FEBS Letters

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Glycerophosphorylcholine (GPC) and glycerophosphorylethanolamine, recently hypothesized to play a central role in phospholipid metabolism, are shown for the first time to be present in higher plants, together with two other unknown phosphodiesters. The GPC concentration is fairly high in young rice (Oryza saliva L.) shoots (0.21 mmol·(kg fresh wt tissue)−). It is progressively reduced by growth in air but considerably increased under anoxia, (0.72 mmol·(kg fresh wt tissue)−), concomitantly with the anoxia‐stimulated elongation of the rice coleoptile. The involvment of GPC concentration in membrane functionality is discussed in the light of a recent hypothesis.

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Section: Discussionmentioning

confidence: 99%

Modulation of glycerophosphorylcholine and glycerophosphorylethanolamine in rice shoots by the environment oxygen level

Menegus¹,

Fronza²

1985

FEBS Letters

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“…LTB4 and 5-HETE may in fact serve as biological amplifiers in the inflammatory process by inducing a further accumulation of polymorphonuclear leukocytes (PMN) at the site of injury [69,120]. Moreover, the hydrolysis of phospholipids by PLA 2 leads to the elaboration of lysophospholipids, which are known to cause detergent-like effects on membranes [181] and to induce apoptosis (via NF-κB) as well as necrosis (Fig. 3) [78,121,122].…”

Section: Death Pathwaysmentioning

confidence: 99%

How Mannheimia haemolytica defeats host defence through a kiss of death mechanism

2005

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-Mannheimia haemolytica induced pneumonias are only observed in goats, sheep and cattle. The bacterium produces several virulence factors,whose principal ones are lipopolysaccharide and leukotoxin. The latter is cytotoxic only for ruminant leukocytes, a phenomenon that is correlated with its ability to bind and interact with the ruminant β2-integrin Lymphocyte Function-associated Antigen 1. This paper globally reviews all the information available on host-pathogen interactions underlying respiratory mannheimiosis (formerly pasteurellosis), from the stable and the Petri dish to the biochemical cascade of events triggered by the leukotoxin inside ruminant leukocytes. One conclusion can be made: the most widespread cattle respiratory disease with the most important impact on beef production worldwide, is probably due to a tiny ruminant-specific focal variation in the CD18-and/or CD11a-expressing genes.

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“…For many years, it has been known that when erythrocytes are incubated with lysophosphatidylcholine (lyso PC) micelles or phospholipid vesicles containing cholesterol, the lyso PC and cholesterol spontaneously transfer to the plasma membrane and dramatically change the shape of these cells [54][55][56]. The changes in shape are the result of increasing the cell surface area by 1% and are consistent with a slight differential expansion of the outer surface of the bilayer.…”

Section: Ii-a Value As An Experimental Toolmentioning

confidence: 99%

Spontaneous lipid transfer between organized lipid assemblies

Brown

1992

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes

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Cytolytic and membrane-perturbing properties of lysophosphatidylcholine

Cited by 572 publications

References 124 publications

Modulation of glycerophosphorylcholine and glycerophosphorylethanolamine in rice shoots by the environment oxygen level

Modulation of glycerophosphorylcholine and glycerophosphorylethanolamine in rice shoots by the environment oxygen level

How Mannheimia haemolytica defeats host defence through a kiss of death mechanism

Spontaneous lipid transfer between organized lipid assemblies

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