Cytomegalovirus adrenalitis mimicking adrenal metastasis in an immunocompetent patient

Park, Jin-Soo; Ben-David, Matan; McKenzie, Catriona; Sandroussi, Charbel

doi:10.1093/jscr/rjac122

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Fetal congenital cytomegalovirus (cCMV) infection occurs due to transplacental CMV transmission. CMV can infect various organs, including the brain, eyes, inner ears, salivary glands, thyroid gland, thymus, heart, lungs, stomach, intestine, liver, spleen, pancreas, kidneys, adrenal glands, epididymis, and testis [1][2][3][4]. The kidneys, lungs, liver, and salivary glands are the most commonly affected organs above [5].…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus DNA Loads in Organs of Congenitally Infected Fetus

Toriyabe,

Kitamura,

Ikejiri

et al. 2024

Preprint

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Congenital cytomegalovirus (cCMV) infection poses significant risks to fetal development, particularly affecting the nervous system. This study reports a fetal autopsy case, examining cCMV infection and focusing on CMV DNA measurements in various fetal organs before formalin fixation, a novel approach for comprehensive CMV DNA evaluations in fetal organs affected by cCMV. A 20-week-old male fetus was diagnosed with cCMV following the detection of CMV DNA in ascites obtained via abdominocentesis in utero. After termination of pregnancy, multiple organs of the fetus, including the cerebrum, thyroid gland, heart, lungs, liver, spleen, kidneys, and adrenal glands, were extracted and examined for CMV DNA loads using real-time polymerase chain reaction. Histopathological examination involved hematoxylin-eosin and CMV-specific immunostaining. A correlation was found between CMV DNA loads and pathology, with higher CMV-infected cell numbers observed in organs positively identified with both staining methods, exhibiting CMV DNA levels of ≥1.0 × 104 copies/mL, compared to those detected solely by CMV-specific immunostaining, where CMV DNA levels ranged from 1.0 x 103 to 1.0 x 104 copies/mL. These results highlight a quantifiable relationship between organ infection extent and CMV DNA concentration, providing insights into cCMV pathogenesis and potentially informing future diagnostic and therapeutic strategies for cCMV infection.

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Section: Introductionmentioning

confidence: 99%

Cytomegalovirus DNA Loads in Organs of Congenitally Infected Fetus

Toriyabe,

Kitamura,

Ikejiri

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Alternatively, another large study in Japan reported that the incidence rate of neonatal cCMV infection was 0.3% [ 2 ]. CMV can infect various organs, including the brain, eyes, inner ears, salivary glands, thyroid gland, thymus, heart, lungs, stomach, intestine, liver, spleen, pancreas, kidneys, adrenal glands, epididymis, and testis [ 3 , 4 , 5 , 6 ]. The kidneys, lungs, liver, and salivary glands are the most commonly affected organs above [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus DNA Loads in Organs of Congenitally Infected Fetus

Toriyabe,

Kitamura,

Ikejiri

et al. 2024

Viruses

View full text Add to dashboard Cite

Congenital cytomegalovirus (cCMV) infection poses significant risks to fetal development, particularly affecting the nervous system. This study reports a fetal autopsy case, examining cCMV infection and focusing on CMV DNA measurements in various fetal organs before formalin fixation, a novel approach for comprehensive CMV DNA evaluations in fetal organs affected by cCMV. A 20-week-old male fetus was diagnosed with cCMV following the detection of CMV DNA in ascites obtained via abdominocentesis in utero. After the termination of pregnancy, multiple organs of the fetus, including the cerebrum, thyroid gland, heart, lungs, liver, spleen, kidneys, and adrenal glands, were extracted and examined for CMV DNA loads using a real-time polymerase chain reaction. Histopathological examination involved hematoxylin–eosin and CMV-specific immunostaining. A correlation was found between CMV DNA loads and pathology, with higher CMV-infected cell numbers observed in organs positively identified with both staining methods, exhibiting CMV DNA levels of ≥1.0 × 104 copies/mL, compared to those detected solely by CMV-specific immunostaining, where CMV DNA levels ranged from 1.0 × 103 to 1.0 × 104 copies/mL. These results highlight a quantifiable relationship between the organ infection extent and CMV DNA concentration, providing insights into cCMV pathogenesis and potentially informing future diagnostic and therapeutic strategies for cCMV infection.

show abstract

Cytomegalovirus adrenalitis mimicking adrenal metastasis in an immunocompetent patient

Cited by 2 publications

References 8 publications

Cytomegalovirus DNA Loads in Organs of Congenitally Infected Fetus

Cytomegalovirus DNA Loads in Organs of Congenitally Infected Fetus

Cytomegalovirus DNA Loads in Organs of Congenitally Infected Fetus

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